Inflammatory Signaling Pathways Involved in Gastrointestinal Diseases

Dear Colleagues, 

Inflammation is a defensive response of the innate and adaptive immune systems against injury and/or harmful microorganisms to restore homeostasis. The importance of inflammatory signaling pathways in diseases has been recognized, and signaling molecules implicated in these pathways are thought to be promising targets for new therapeutic strategies. Many studies have demonstrated that inflammation-related signaling pathways influence the homeostasis and health of the human gastrointestinal system.

The main goal of this Issue is to shed light, through both original research and review articles, on the role of immune inflammatory signaling pathways in gastrointestinal inflammation and tumors, and on the latest progress in the corresponding regulatory mechanisms. We also welcome the submission of research papers evaluating strategies to reduce inflammation in inflammatory gastrointestinal diseases. Meanwhile, this Issue explores the effects and mechanisms of different signaling pathways in tumors such as gastric cancer and colorectal cancer, as well as inflammatory diseases such as inflammatory bowel disease (IBD), intestinal-related sepsis, colonitis and celiac disease. Full knowledge of the inflammatory signaling pathways could be helpful not only for the prevention but also for the novel treatment of these diseases.

Generally, pure clinical research or model studies, survey studies, and correlation research are outside of the scope of IJMS. However, clinical or model submissions with biomolecular experiments are welcomed.

Dr. Diana Di Liberto
Dr. Marianna Lauricella
Guest Editors

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