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Molecular and Translational Research in Cardiovascular Endocrinology, Cardiovascular–Kidney–Metabolic Diseases and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): 3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 1739

Special Issue Editors


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Guest Editor
1. Department of Biochemistry, Medical School of Athens, National and Kapodistrian University of Athens, 11527 Athens, Greece
2. Unit of Endocrinology, First Department of Propaedeutic Internal Medicine, Laiko Hospital, National & Kapodistrian University of Athens, 11527 Athens, Greece
Interests: women's health; cardiovascular endocrinology; atherosclerosis; non-alcoholic fatty liver disease; endocrinology of adrenals; oestrogen receptor signalling; glucocorticoid receptor signalling; clock system in benign diseases and malignancies; ICI (immune checkpoint inhibitor)-related endocrinopathies; neuroendocrine tumours; vitamin D; calcium and phosphate metabolic disorders; gynaecological cancers
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Guest Editor
1. Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
2. Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry CV2 2DX, UK
3. Centre for Sport, Exercise and Life Sciences, Research Institute for Health & Wellbeing, Coventry University, Coventry CV1 5FB, UK
4. Aston Medical School, College of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK
5. Laboratory of Dietetics and Quality of Life, Department of Food Science and Human Nutrition, School of Food and Nutritional Sciences, Agricultural University of Athens, 11855 Athens, Greece
Interests: metabolism and energy homeostasis; nutrition; cardiovascular endocrinology; cardiovascular disease and atherosclerosis; exercise and health; COVID 19; epidemiology of non-communicable diseases and public health; obesity and obesity-related complications; type 2 diabetes; non-alcoholic fatty liver disease (NAFLD); endocrinology; endocrine-disrupting chemicals; polycystic ovary syndrome (PCOS); mental-health stress and the HPA axis
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK
2. Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire NHS Trust, Coventry CV2 2DX, UK
3. Centre for Sport, Exercise and Life Sciences, Research Institute for Health & Wellbeing, Coventry University, Coventry CV1 5FB, UK
Interests: endocrinology; PCOS; women’s health; metabolism; diabetes; obesity; primary care; health inequalities; reproductive health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of the publications “Molecular and Translational Research in Cardiovascular Endocrinology, Cardio-Metabolic Diseases and Non-Alcoholic Fatty Liver Disease (NAFLD)” and “Molecular and Translational Research in Cardiovascular Endocrinology, Cardio-Metabolic Diseases and Non-Alcoholic Fatty Liver Disease (NAFLD): 2nd Edition”. This publication, which is edited by Prof E. Kassi, As. Prof. I. Kyrou and Prof. H.S. Randeva with the aid of our Topical Advisory Panel Member Dr. Narjes Nasiri-Ansari (Department of Biochemistry, Medical School, National and Kapodistrian University of Athens, Greece), focuses on cardiovascular–kidney–metabolic health and endocrine-related cardiovascular diseases, including atherosclerosis, heart failure, arterial hypertension, cardiovascular–kidney–metabolic syndrome, obesity, diabetes mellitus, chronic kidney disease, MASLD, and dyslipidemia, ranging from the molecular and cellular pathogenetic pathways to novel pharmacological and molecular targets for relevant treatments.

Cardiovascular tissues are recognized as dynamic endocrine organs, with vital stimuli that affect the cardiovascular system, acting in an endocrine manner through hormone receptors. Many of these signaling systems are complex and so interconnected that, in many cases, the interlinked components are hard to separate.

Thus, cardiovascular disease, endocrinology, diabetes and metabolism represent closely linked disciplines, giving rise to the field of cardiovascular endocrinology. Moreover, pituitary, adrenal, parathyroid, thyroid and gender hormone excesses or deficiencies, as well as glucose and lipid metabolism disorders, may further impact cardiovascular disease risk (e.g., directly or indirectly through atherosclerosis, heart failure and metabolic dysfunction-associated steatotic liver disease, MASLD).

Despite the important advances in the field of cardiovascular endocrinology through recent molecular and translational research, there are still open issues regarding underlying pathogenetic mechanisms, as well as the exact effects/impact of various interventions/treatments, such as lifestyle modification interventions (e.g., dietary and exercise interventions) or pharmacological therapies (e.g., anti-hypertensive, lipid-lowering, anti-diabetic drugs, etc.), which may target more than one aspects/factors of cardiovascular–kidney–metabolic diseases.

Original research articles and reviews on these and any related topics are welcomed in this Special Issue.

Prof. Dr. Eva Kassi
Dr. Ioannis Kyrou
Dr. Harpal S. S. Randeva
Guest Editors

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Keywords

  • cardiovascular endocrinology
  • atherosclerosis
  • coronary artery disease
  • endocrine hypertension
  • non-alcoholic fatty liver disease (NAFLD)
  • diabetes mellitus and obesity
  • metabolic syndrome
  • endothelial cells
  • vascular inflammation
  • antidiabetic drugs
  • antihypertensive treatments
  • lipid lowering treatments
  • lifestyle interventions
  • molecular targeted therapies
  • heart failure
  • chronic kidney disease

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Published Papers (3 papers)

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Research

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13 pages, 4625 KB  
Article
Loss of Hepatocyte FOXA3 Improves MASH and Atherosclerosis in Hyperlipidemic Ldlr-Deficient Mice
by Hui Wang, Shuwei Hu, Jiayou Wang, Raja Gopoju, Li Lin, Lakshitha Gunawardana, Xinwen Wang, Liya Yin and Yanqiao Zhang
Int. J. Mol. Sci. 2026, 27(3), 1468; https://doi.org/10.3390/ijms27031468 - 2 Feb 2026
Viewed by 752
Abstract
Forkhead box protein A3 (FOXA3), also known as hepatocyte nuclear factor 3g (HNF3g), is a member of the FOX family of transcription factors and regulates lipid and glucose metabolism and liver regeneration. Hepatic FOXA3 is reduced in obesity and patients with metabolic dysfunction-associated [...] Read more.
Forkhead box protein A3 (FOXA3), also known as hepatocyte nuclear factor 3g (HNF3g), is a member of the FOX family of transcription factors and regulates lipid and glucose metabolism and liver regeneration. Hepatic FOXA3 is reduced in obesity and patients with metabolic dysfunction-associated steatohepatitis (MASH). So far, it remains unknown whether hepatic FOXA3 is essential for regulating lipid metabolism or metabolic dysfunction-associated liver disease (MASLD). In this study, we first investigated whether genetic inactivation of hepatocyte Foxa3 affected the development of MASLD/MASH in C57BL/6 mice and then explored whether loss of hepatocyte Foxa3 regulated atherosclerosis development in Ldlr-deficient mice. Inactivation of Foxa3 in hepatocytes did not affect the development of Western diet-induced MASLD/MASH in C57BL/6 mice but attenuated MASH development in Western diet-fed Ldlr-deficient mice. Moreover, genetic loss of hepatocyte Foxa3 ameliorated hyperlipidemia and atherosclerosis in Ldlr-deficient mice. In Ldlr-deficient mice, loss of hepatocyte Foxa3 resulted in reduced expression of lipogenic, pro-inflammatory, or fibrogenic genes in the liver and reduced cholic acid levels in plasma and bile. Thus, hepatocyte FOXA3 loss confers protection against the development of MASH and atherosclerosis in hyperlipidemic Ldlr-deficient mice. Full article
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11 pages, 1026 KB  
Article
Effects of N3SA Analogues on Cerebral and Peripheral Arteriolar Vasomotion in Spontaneously Hypertensive Rats
by Dominga Lapi, Giuseppe Federighi, Maria Paola Tramonti Fantozzi, Gianpiero Garau and Rossana Scuri
Int. J. Mol. Sci. 2026, 27(2), 1006; https://doi.org/10.3390/ijms27021006 - 20 Jan 2026
Viewed by 328
Abstract
Thiazides are among the most efficacious and commonly used drugs for the treatment of hypertension. The nanomolar stabilizer N3SA binds specifically to the recently discovered thiazide-binding site of the membrane target NAPE-PLD, showing sustained arterial blood pressure-lowering effects and vasodilation in spontaneous hypertensive [...] Read more.
Thiazides are among the most efficacious and commonly used drugs for the treatment of hypertension. The nanomolar stabilizer N3SA binds specifically to the recently discovered thiazide-binding site of the membrane target NAPE-PLD, showing sustained arterial blood pressure-lowering effects and vasodilation in spontaneous hypertensive rats (SHRs). To further support the relation between stabilizers anchored to NAPE-PLD and their beneficial effects on hypertension, we selected compound analogues of N3SA with chemical modifications at the three target-interacting sulfonic groups, including the drug Suramin. Each compound was injected i.v in an adult SHR (systolic blood pressure of 217 ± 5 mmHg) to evaluate the frequency components contribution to cerebral and peripheral arteriolar vasomotion. We visualized the pial and rectus femoral muscle microcirculation by Epi-illumination, measuring changes in the rhythmic arteriolar diameter. Findings showed that the minor structural differences in compounds correlated with the contribution of the six different frequency components affecting the arterial tone, as well as their vasodilatory effects, in both cerebral and femoral muscle arterioles. These results provide evidence that the spectra analysis of the regulation mechanisms of vascular tone and arterial blood pressure can accurately reflect the structure–activity correlations of different analogues of an antihypertensive compound. Full article
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Review

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22 pages, 1947 KB  
Review
Biomarkers and Endothelial Damage in Obesity: An Insight into the Pharmacological Modulation
by Arturo Yonatan Bojórquez-González, Eduardo Gómez-Sánchez, Daniel Osmar Suarez-Rico, Alberto Beltrán-Ramírez, Luis Ricardo Balleza-Alejandri, Luis Daniel López-Murillo, Ernesto Javier Ramírez-Lizardo and Jesús Jonathan García-Galindo
Int. J. Mol. Sci. 2026, 27(8), 3694; https://doi.org/10.3390/ijms27083694 - 21 Apr 2026
Viewed by 273
Abstract
Obesity drives chronic low-grade inflammation and endothelial dysfunction, key contributors to subclinical atherosclerosis. This review focuses on the netrin 1/UNC5B axis and its role in promoting macrophage retention within adipose tissue and atherosclerotic plaques, thereby perpetuating local inflammation and vascular injury. Complementary inflammatory [...] Read more.
Obesity drives chronic low-grade inflammation and endothelial dysfunction, key contributors to subclinical atherosclerosis. This review focuses on the netrin 1/UNC5B axis and its role in promoting macrophage retention within adipose tissue and atherosclerotic plaques, thereby perpetuating local inflammation and vascular injury. Complementary inflammatory markers—including IL 6, hsCRP, and IL 15—are discussed as indicators of systemic inflammatory burden, whereas endocan and ICAM 1 are briefly addressed as markers of endothelial activation. Among emerging pharmacological strategies, glucagon-like peptide-1 receptor agonists (GLP 1RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2is) show the most consistent evidence for improving these biomarkers and reducing endothelial damage, with GLP 1RAs demonstrating direct effects on carotid intima–media thickness. Integrating biomarker profiling with obesity phenotypes may improve early risk stratification and support more precise management of subclinical atherosclerosis. Full article
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