71,550 Results Found

Monkeypox is a serious public health issue in tropical and subtropical areas. Antivirals that target monkeypox proteins might lead to more effective and efficient therapy. The F13 protein is essential for the growth and maturation of the monkeypox vi...

Vaccinia virus (VACV) belongs to the genus Orthopoxvirus of the family Poxviridae. There are four different forms of infectious virus particles: intracellular mature virus (IMV), intracellular en-veloped virus (IEV), cell-associated enveloped virus (...

Heterologous protein expression often faces significant challenges, particularly when the target protein has posttranslational modifications, is toxic, or is prone to misfolding. These issues can result in low expression levels, aggregation, or even...

In this study, we developed and characterized novel scintillators with Ce: LiCaAlF₆–CaF₂–Li₃AlF₆ and Ce: CaF₂–LiF–Li₃AlF₆ ternary systems for thermal neutron detectors. The eutectics were grown by the vertical Stochbarger-Brid...

This paper shows that certain ${}_{3}F_4$ hypergeometric functions can be expanded in sums of pair products of ${}_{1}F_2$ functions. In special cases, the ${}_{3}F_4$ hypergeometric functions reduce to ${}_{2}F_3$ functions. Further special cases allow one to reduce the ${}_{2}F_3$ functi...

This paper shows that certain${ }_3{F}_4$ hypergeometric functions can be expanded in sums of pair products of${ }_2{F}_3$ functions, which reduce in special cases to${ }_2{F}_3$ functions expanded in sums of pair products of${ }_1{F}_2$ functions. This expands...

Radiopharmaceuticals targeting the prostate-specific membrane antigen (PSMA) has become the gold standard for PET imaging of prostate cancer. [⁶⁸Ga]Ga-PSMA-11 has been the forerunner but a [¹⁸F]F-PSMA ligand has been developed because of the intrinsi...

A quantification technique for costal cartilage calcification using ¹⁸F-sodium fluoride–positron emission tomography/computed tomography (¹⁸F-NaF-PET/CT) has yet to be established, and the effects of aging and other demographic variables on cos...

Losartan is widely used in clinics to treat cardiovascular related diseases by selectively blocking the angiotensin II type 1 receptors (AT₁Rs), which regulate the renin-angiotensin system (RAS). Therefore, monitoring the physiological and pathologic...

In this study, brazing AA6061 to Q235 steel using flame brazing was performed with 70.9 wt.% CsF-0.5 wt.% RbF-28.6 wt.% AlF₃ fluxes doped with GaF₃, ZnF₂, Zn(BF₄)₂ and Ga₂O₃ nanoparticles, matched with a Zn-15Al filler metal, and the spreadability of...

f-biharmonic maps are generalizations of harmonic maps and biharmonic maps. In this paper, we give some descriptions of f-biharmonic curves in a space form. We also obtain a complete classification of proper f-biharmonic isometric immersions of a dev...

The effect of BaF₂, MgF₂, and AlF₃ on the structural and luminescent properties of gallo-germanate glass (BGG) doped with erbium ions was investigated. A detailed analysis of infrared and Raman spectra shows that the local environment of erbium ions...

Positron emission tomography (PET) imaging with ¹⁸F-fluorodeoxyglucose (FDG) represents a method of detecting and characterizing arterial wall inflammation, with potential applications in the early assessment of vascular disorders such as atheroscler...

C-Met is a receptor tyrosine kinase that is overexpressed in a range of different cancer types, and has been identified as a potential biomarker for cancer imaging and therapy. Previously, a ⁶⁸Ga-labelled peptide, [⁶⁸Ga]Ga-EMP-100, has shown promise...

This study aims to investigate if vaginal bacteriology obtained prior to treatment influences the 3′-deoxy-3 18F-fluorothymidine (FLT) [¹⁸F]FLT and 2-deoxy-2-[¹⁸F]fluoro-d-glucose (2-[¹⁸F]FDG) [¹⁸F]FDG parameters in positron emission tomography...

Purpose: To analyse diagnostic and therapeutic impact of molecular imaging TNM (miTNM) stage obtained with [¹⁸F]DCFPyL versus [¹⁸F]F-choline in head-to-head comparison in biochemical recurrence (BCR) of prostate cancer (PCa). Material and methods: Pa...

The present paper is dedicated to the quantitative determination of oxygen-containing impurities in the LiF–NaF–KF eutectic using electrochemical (cyclic and square-wave voltammetry) and reduction melting methods. The LiF–NaF–...

The effect of trace amounts of GaF₃ and Ga₂O₃ nanoparticles on the wettability and spreadability of CsF-AlF₃ flux matched Zn-15Al filler metal were comparatively studied on 6061 aluminum alloy and Q235 low-carbon steel. The experimental results indic...

In this paper, we noticed that the existence of fixed points of F-contractions, in $\mathcal{F}$ -metric space, can be ensured without the third condition (F3) imposed on the Wardowski function $F:(0,\infty )\to \mathbb{R}$ . We obtain fixed points as...

Background/Objectives: Sarcopenia is a progressive decline in skeletal muscle strength and mass, leading to decreased functionality, metabolic disorders, morbidity, and mortality. There are a number of sarcopenia screening tools, such as the SARC-F q...

Hepatitis B virus (HBV) is classified into ten genotypes and numerous subgenotypes (sgt). In particular, sgt F1b and sgt F4, native of Latin America, have been associated with differences in clinical and virological characteristics. Hepatitis B virus...

Diode-pumped solid-state lasers using novel Yb:LaF₃ and Tm,Ho:LaF₃ crystals as laser gain materials are demonstrated herein. The Yb:LaF₃ and Tm,Ho:LaF₃ crystals were grown using the Bridgman method. By matching their absorption bands, continuous-wave...

This paper proposes the use of environmentally friendly alternatives, C₆F₆ and C₄H₂F₆, as perfluorocarbon (PFC) and hydrofluorocarbon (HFC) precursors, respectively, for SiO₂ plasma etching, instead of conventional precursors C₄F₈ and CHF₃. The study...

Solute carriers (SLCs) mediate cell- and organelle-specific import and export of nutrients and metabolites required for every biochemical process that occurs in a cell. Functional studies have ascribed activities to many human genes annotated as SLCs...

The close interplay between thrombotic and immunologic processes plays an important physiological role in the immune defence after tissue injury and has the aim to reduce damage and to prevent the spread of invading pathogens. However, the uncontroll...

[¹⁸F]sodium fluoride ([¹⁸F]NaF) is recognised to be superior to [⁹⁹mTc]-methyl diphosphate ([^99mTc]Tc-MDP) and 2-deoxy-2-[¹⁸F]fluoro-D-glucose ([¹⁸F]FDG) in bone imaging. However, there is concern that [¹⁸F]NaF uptake is not cancer-specific, leading...

Herein, we present a one-step labeling procedure of N-succinimidyl-4-[¹⁸F]-fluorobenzoate ([¹⁸F]SFB) starting from spirocyclic iodonium ylide precursors. Precursor syntheses succeeded via a simple one-pot, two-step synthesis sequence, in yields of ap...

¹⁸F-labelled radiopharmaceuticals are indispensable in positron emission tomography. The critical step in the preparation of ¹⁸F-labelled tracers is the anhydrous F-18 nucleophilic substitution reaction, which involves [¹⁸F]F⁻ anions generated...

[¹⁸F]F-DOPA is widely used in PET diagnostics. Diseases diagnosed with this tracer are schizophrenia, Parkinson’s disease, gliomas, neuroendocrine tumors, pheochromocytomas, and pancreatic adenocarcinoma. It should be noted that the [¹⁸F]F-DOPA...

The experimental exploration of halo nuclei over the past four decades has established ground-state halo phenomena in about twenty nuclei, providing important benchmarks for modern nuclear theories. The deformed relativistic Hartree–Bogoliubov...

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic bone disorder characterized by episodic flare-ups in connective tissue, which are frequently followed by the formation of heterotopic ossification. The absence of available plasma-soluble...

This study developed machine learning models using different algorithms, including support vector machine (SVM), random forest (RF), and backpropagation neural network (BPNN), to estimate the critical frequency of the F2 layer (foF2) and the maximum...

With the growing global emphasis on nuclear reactor decommissioning, reliable thermal neutron detection has become increasingly important for ensuring critical safety and for the identification of fuel debris and radioactive waste. In this context, t...

The peculiarities of interatomic interactions formed by fluorine atoms were studied in four tosylate derivatives p-CH₃C₆H₄OSO₂CH₂CF₂CF₃ and p-CH₃C₆H₄OSO₂CH₂(CF₂)_nCHF₂ (n = 1, 5, 7) using X-ray diffraction and quantum chemical calculations. Compounds...

Efficient ¹⁸F-fluorination procedures for the production of radiopharmaceuticals are urgently needed to satisfy the increasing demand for clinical diagnostics using positron emission tomography (PET). However, the development of PET tracers is often...

Background/Objectives: Fibroblast activation protein inhibitor (FAPI)-directed PET/CT has emerged as a promising approach for non-invasive assessment of arterial wall pathology. While a target-to-background ratio (TBR) threshold of 1.6 has previously...

In this paper, we introduce a geometry called F-geometry on a statistical manifold S using an embedding F of S into the space R_X of random variables. Amari’s α-geometry is a special case of F-geometry. Then using the embedding F and a positive smooth...

To further explore the scope of our recently developed “fluorination on Sep-Pak” method, we prepared two well-known positron emission tomography (PET) tracers 21-[¹⁸F]fluoro-16α,17α-[(R)-(1′-α-furylmethylidene)diox...

The SLC35 (Solute Carrier 35) family members acting as nucleotide sugar transporters are typically localized in the endoplasmic reticulum or Golgi apparatus. It is, therefore, intriguing that some reports document the presence of orphan transporters...

There is an unmet need for positron emission tomography (PET) radiotracers that can image bone disease in multiple myeloma (MM) in a more sensitive and specific way than the widely used ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG). Sodium fluoride (¹⁸F-NaF) is a...

Vitamin E, a natural antioxidant, is of interest to scientists, health care pundits and faddists; its nutritional and biomedical attributes may be validated, anecdotal or fantasy. Vitamin E is a mixture of tocopherols (TPs) and tocotrienols (T-3s), e...

Our aim was to assess the role of positron emission computed tomography (PET/CT) with ¹⁸F-choline (¹⁸F-FCH) or ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) in hepatocellular carcinoma (HCC) submitted to ⁹⁰Y-radioembolization (⁹⁰Y-TARE). We retrospectively analyz...

Active microcalcification of elastic fibers is a hallmark of pseudoxanthoma elasticum and it can be measured with the assessment of deposition of 18F-NaF using a PET/CT scan at the skin and vascular levels. It is not known whether this deposition cha...

Background/Objectives: PET imaging with [¹⁸F]F-DOPA has demonstrated high potential for the evaluation and management of pediatric brain gliomas. Manual extraction of PET parameters is time-consuming, lacks reproducibility, and varies with operator e...

Pseudoxanthoma elasticum (PXE) is a genetic disease characterized by the calcification of elastin fibers. Our aim was to quantify vascular calcification in the arteries and the deposition of 18F-sodium-fluoride (18F-NaF) in the skin and vessel walls...

This study aims to provide some new classes of $(\alpha ,\beta ,F^{*})$-weak Geraghty contraction and $(\alpha ,\beta ,F^{**})$-weak Geraghty contraction, which are self-generalized contractions on any metric space. Furthermore, we find that the mappings satis...

A growing number of SmallSat/CubeSat constellations with high-rate (50–100 Hz) global navigation satellite system radio occultations (GNSS-RO) as well as low-rate (1 Hz) precise orbit determination (GNSS-POD) limb-viewing capabilities provide u...

The interest of geometers in f-structures is motivated by the study of the dynamics of contact foliations, as well as their applications in physics. A weak f-structure on a smooth manifold, introduced by the author and R. Wolak, generalizes K. Yano&r...

[¹⁸F]NaF PET measurements of bone metabolic flux (K_i) are conventionally obtained with 60-min dynamic scans analysed using the Hawkins model. However, long scan times make this method expensive and uncomfortable for subjects. Therefore, we evaluated...

CFTR modulators have significantly affected the prognosis for cystic fibrosis, improving the clinical course in most patients with the F508del variant and several other CFTR gene variants. The presence of complex alleles, including more than one vari...