Medical Sciences Forum, Volume 14, Issue 1

Ceftriaxone (CTX) a third-generation cephalosporin, is a broad-spectrum antibiotic that can be administered via intramuscular or intravenous routes to treat various types of infection. However, CTX has poor cellular penetration and poor diffusion due...

Cryogels are macroporous hydrogels prepared by cryo-gelation: a green technique that involves radical polymerization using water as a solvent [...]

G protein-coupled receptors (GPCRs) are omnipresent in the regulation of physiological processes and therefore account for the most prominent drug target class. However, nearly all drugs targeting GPCRs have been developed by the concept of receptors...

Nepeta cyrenaica Quézel & Zaffran (Lamiaceae), an endemic species of the Libyan flora, has been scarcely explored until now. Since Nepeta species are proven as pharmacologically active plants rich in iridoid monoterpenes, this study was ai...

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by multiple factors, such as the progressive decline in the levels of the neurotransmitter acetylcholine, and the deregulation of the homeostasis of bio-metals, such as coppe...

Triple-negative breast cancer (TNBC), a poor survival cancer has high resistance to therapy, with low-drug efficacy. Adenosine is present in high concentrations in the tumor microenvironment. Recently, adenosine was found to sensitize ovarian cisplat...

The number of multidrug resistant (MDR) cancer cases across the globe is continuing to rise, such that the search for novel anti-cancer therapeutics is paramount. For instance, the overexpression of membrane transport proteins, such as P-glycoprotein...

A number of novel 1, 3, 4-oxadiazole analogues have been designed and synthesized through the condensation of substituted aldehyde/ketone with substituted benzohydrazide to form substituted N′-alkylidene benzohydrazide and then cyclization of N...

Small metabolites and venom metabolites produced by insects are known to exhibit biological activity. These metabolites could be used to develop natural product-based therapeutics. To screen for these metabolites, insects must be collected and accura...

Triple-negative breast cancer (TNBC) is an aggressive breast carcinoma with a poor prognosis. Current treatment options with platinum-(Pt)-based chemotherapeutics are limited by toxicity/acquired resistance, which has prompted the search for novel me...