Skin and Arterial Wall Deposits of 18F-NaF and Severity of Disease in Patients with Pseudoxanthoma Elasticum
Abstract
:1. Introduction
2. Experimental Section
3. Results
3.1. General Data
3.2. Skin and Vascular Uptake of 18F-NaF
3.3. Vascular Calcium Score
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Territory | TBRmax | TBRmean |
---|---|---|
Lumbar skin SUV | 0.54 (0.47–0.81) | 0.39 (0.31–0.54) |
Neck | ||
Right | 5.91 (3.68–13.39) | 4.14 (2.41–9.43) |
Left | 6.67 (3.32–13.4) | 3.53 (2.20–8.96) |
Axillae | ||
Right | 5.89 (3.47–9.93) | 3.67 (2.30–6.11) |
Left | 5.00 (3.13–9.97) | 3.19 (2.00–3,35) |
Elbow | ||
Right | 2.32 (1.08–4.45) | 1.72 (0.97–3.35) |
Left | 1.86 (0.99–5.35) | 1.44 (0.70–3.67) |
Groin | ||
Right | 4.09 (1.42–6.14) | 2.93 (1.15–4.04) |
Left | 2.08 (1.47–5.69) | 1.54 (1.09–4.10) |
Popliteal | ||
Right | 3.24 (2.52–4.93) | 2.16 (1.56–3.51) |
Left | 3.21 (2.19–4.89) | 2.10 (1.56–3.51) |
AVERAGE | 4.22 (2.44–7.64) | 2.79 (1.71–5.32) |
PHENODEX | |||
---|---|---|---|
< p50 | > p50 | Sig | |
Av Vasc TBRmax | 2.03 (1.80–275) | 2.60 (2.24–2.84) | NS |
Av Vasc TBRmean | 1.73 (1.62–2.32) | 2.16 (1.74–2.37) | NS |
Av Skin TBRmax | 4.38 (2.29–9.30) | 4.07 (2.92-–6.38) | NS |
Av Skin TBRmean | 2.64 (1.52–6.23) | 2.94 (2.05–4.63) | NS |
Av calcium score | 1.50 (0.25–41) | 301 (159–541) | p < 0.05 |
Territory | Number | Calcium Score | Calcium Volume | Calcium Mass |
---|---|---|---|---|
Carotid | 7 | |||
Right | 0 (0–33,6) | 0 (0–29,0) | 0 (0–18,4) | |
Left | 0 (0–18.4) | 0 (0–20,7) | 0 (0–3,4) | |
Ascending aorta | 3 | 0 (0–0) | 0 (0–0) | 0 (0–0) |
Aortic arch | 10 | 9 (0–54) | 24 (0–75) | 2.9 (0–12) |
Descending aorta | 6 | 0 (0–168) | 0 (0–186) | 0 (0–33) |
Abdominal aorta | 7 | 38 (0–447) | 36 (0–409) | 7.8 (0–105) |
Iliac | 8 | |||
Right | 0 (0–517) | 0 (0–436) | 0 (0–107) | |
Left | 0 (0–279) | 0 (0–236) | 0 (0–62) | |
Femoral | 10 | |||
Right | 101 (0–684) | 137 (0–680) | 22 (0–143) | |
Left | 82 (0–732) | 70 (0–693) | 14 (0–136) | |
Popliteal | 12 | |||
Right | 20 (0–493) | 43 (0.775) | 6 (0–116) | |
Left | 21 (0–489) | 40 (0–745) | 5 (0–112) |
Territory | TBRmax | TBRmean |
---|---|---|
SUV/cava | 0.88 (0.72–0.98) | 0.67 (0.48–0.76) |
Carotid | ||
Right | 1,74 (1.43–2.19) | 1,58 (1.27–1.97) |
Left | 1.83 (1.53–2.35) | 1.64 (1.29-1.96) |
Aorta | ||
Ascending | 1.60 (1.41–1.89) | 1.26 (1.15–1.50) |
Arch | 2.16 (1.72–2.34) | 1.69 (1.40–1.87) |
Descending | 2.79 (2.19–3.22) | 2.21 (1.78–2.85) |
Abdominal | 3.88 (3.36–4.64) | 3.31 (2.79–4.04) |
Iliac | ||
Right | 2.11 (1.54–2.92) | 1.72 (1.04–2.30) |
Left | 1.93 (1.40–2.40) | 1.59 (1.20–2.01) |
Femoral | ||
Right | 2.83 (2.44–3.34) | 2.23 (1.84–2.86) |
Left | 2.88 (2.26–3.70) | 2.34 (1.88–2.66) |
Popliteal | ||
Right | 1.73 (1.15–2.20) | 1.48 (0.98–1.74) |
Left | 2.00 (1.31–2.60) | 1.52 (1.10–2.21) |
AVERAGED | 2.53 (2.00–2.78) | 2.00 (1.64–2.32) |
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Gutierrez-Cardo, A.; Lillo, E.; Murcia-Casas, B.; Carrillo-Linares, J.L.; García-Argüello, F.; Sánchez-Sánchez, P.; Rodriguez-Morata, A.; Baquero Aranda, I.; Sánchez-Chaparro, M.Á.; García-Fernández, M.; et al. Skin and Arterial Wall Deposits of 18F-NaF and Severity of Disease in Patients with Pseudoxanthoma Elasticum. J. Clin. Med. 2020, 9, 1393. https://doi.org/10.3390/jcm9051393
Gutierrez-Cardo A, Lillo E, Murcia-Casas B, Carrillo-Linares JL, García-Argüello F, Sánchez-Sánchez P, Rodriguez-Morata A, Baquero Aranda I, Sánchez-Chaparro MÁ, García-Fernández M, et al. Skin and Arterial Wall Deposits of 18F-NaF and Severity of Disease in Patients with Pseudoxanthoma Elasticum. Journal of Clinical Medicine. 2020; 9(5):1393. https://doi.org/10.3390/jcm9051393
Chicago/Turabian StyleGutierrez-Cardo, Antonio, Eugenia Lillo, Belén Murcia-Casas, Juan Luis Carrillo-Linares, Francisco García-Argüello, Purificación Sánchez-Sánchez, Alejandro Rodriguez-Morata, Isabel Baquero Aranda, Miguel Ángel Sánchez-Chaparro, María García-Fernández, and et al. 2020. "Skin and Arterial Wall Deposits of 18F-NaF and Severity of Disease in Patients with Pseudoxanthoma Elasticum" Journal of Clinical Medicine 9, no. 5: 1393. https://doi.org/10.3390/jcm9051393