2,059,952 Results Found

Preclinical drug development suffers from a persistent translational gap, as conventional animal models fail to reproduce the human immune response, contributing to high attrition rates of drug candidates in clinical trials. To address this, we previ...

Grass carp hemorrhagic disease (GCHD) induced by grass carp reovirus (GCRV) causes severe economic losses in the grass carp aquaculture industry, and breeding for GCRV resistance is of great significance for disease prevention and genetic improvement...

Intertidal red algae show much stronger tolerance to hypersaline stress than terrestrial plants. However, the characteristics of Ca²⁺ signaling and the SOS-related ion regulatory mechanisms involved in their hypersaline stress responses remain unclea...

The transition from conventional manufacturing processes to flexible production systems represents a key enabler for improving adaptability for faster product change and therefore manufacturing efficiency. However, the increased complexity of such ma...

Wild canids inhabiting anthropized landscapes can act as environmental indicators and potential reservoirs of zoonotic parasites, connecting transmission cycles among wild, domestic, and human hosts. We aimed to identify and characterize helminths in...

Zoology has entered an era in which molecular approaches are no longer ancillary tools, but central components to grasp animal diversity, evolution, physiology, adaptation, and conservation [...]

Immune imprinting shapes every subsequent response to antigenically related pathogens and is now central to designing updated vaccines for influenza, SARS-CoV-2, and respiratory syncytial virus (RSV). The label “Original Antigenic Sin” ha...

Land subsidence is a geohazard in groundwater-dependent regions, requiring assessment to support hazard mitigation and regional planning. This study presents an integrated framework combining Sentinel-1 deformation monitoring and machine learning-bas...

Background: Erythrocyte proteins released into plasma carry oxidation-related annotations and can be read as evidence of oxidative stress. We examined whether this applies to an oxidative-stress enrichment reported in a plasma proteomic study of obst...

Cancer cells hijack RNA metabolism, including splicing, polyadenylation, nuclear export and translation, to change both the amount and the form of the proteins they produce. This creates therapeutic vulnerabilities beyond the mutations and translocat...

Background/Objectives: Sustained drug-free status is an emerging milestone after atezolizumab plus bevacizumab for unresectable hepatocellular carcinoma. We examined baseline host biomarkers associated with achievement of 6-month sustained drug-free...

Noise-induced spectral fluctuations can substantially degrade gas concentration retrieval in tunable diode laser absorption spectroscopy (TDLAS), particularly when the absorption features are weak. A coordinate-attention-enhanced convolutional neural...

Background/Objectives: Phenoconversion extends pharmacogenomics beyond genetic variation by accounting for non-genetic factors that can also dynamically alter metabolism, influence treatment response, adverse effect risk and overall patient outcomes....

Background/Objectives: Pharmacovigilance studies typically evaluate adverse events as isolated drug–event pairs, potentially overlooking symptoms and functional impairments reported concurrently within the same case. We investigated co-reported...

Piezoelectric braided cords composed of poly-L-lactic acid (PLLA) fibers can be integrated into textiles to detect mechanical signals without requiring sensors to be attached directly to the body. In this study, we investigated the potential of a bed...

Most spoken word recognition models assume that a target word co-activates phonologically similar neighbors that compete for recognition, a process reflected in inhibitory neighborhood density effects. Sign languages provide a critical test for the g...

The transition towards a circular economy has significantly increased the use of recycled construction materials, including products intended for interior applications. While the environmental benefits of material recycling are well recognised, consi...

Agricultural compression-ignition engines require decarbonization strategies that can reduce fossil-diesel demand without replacing robust power units already operating in the field. This study experimentally evaluates an autonomous hydrous-ethanol p...

Conventional indicators such as out-of-pocket expenditure (OOP), catastrophic health expenditure (CHE), and impoverishing health expenditure (IHE) capture important dimensions of financial hardship but do not fully represent the structural conditions...

Generative Artificial Intelligence (AI) has increased in popularity in recent years, providing enhanced experiences to users and advancing many fields [...]

Protecting-group-free glycosylation reduces the steps needed to convert native sugars into glycosides, but selectivity and product isolation remain major limits. This review examines methods published mainly from 2024 to August 2026. It compares dono...

Accurate prediction of anchorage support parameters is important for the design of underground caverns. However, the limited availability of engineering cases makes it difficult to establish reliable data-driven prediction models. In this study, a ne...

High-frequency transient events in power systems are becoming increasingly significant due to lightning impulses, growing penetration of renewable energy sources, high-voltage direct current (HVDC) transmission systems, and power-electronic-interface...

Objective: To explore the incremental prognostic information of fetal Doppler measurements beyond maternal and fetal biometric characteristics for adverse perinatal outcomes in pregnancies with suspected fetal smallness. Methods: This retrospective c...

Allergic contact dermatitis (ACD) is a prevalent condition traditionally diagnosed using standardized patch testing, a method limited by subjective visual skin evaluation and delayed skin reaction manifestations. This study introduces a novel “...

The article examines progress in the system integration of renewable energy sources in China over the period 2020–2026, focusing on the challenge of integrating rapidly expanding renewable energy capacity into the power system. The study adopts...

Ice cream, a favorite among consumers of all ages, is a dairy product highly suitable for experimenting with new formulations to meet nutritional and health demands, and for enriching its nutritional profile with microalgae. In this context, in the p...

Listeria monocytogenes causes listeriosis, a relatively rare but severe disease associated with high mortality rates, particularly among in high-risk populations. To reduce its presence in food production environments and increase the microbiological...

Obesity in the 21st century has become a global epidemic owing to its heterogeneous aetiology and clinical presentation, as well as the development of associated comorbidities such as cardiovascular disease, type2 diabetes, hypertension, dyslipidaemi...

Vegetation-induced temporal decorrelation limits the reliability of time-series InSAR measurements over densely vegetated areas. Existing empirical models generally use NDVI from a single acquisition and therefore cannot represent vegetation changes...

Reliable visual sensing is important for UAV-assisted monitoring of live-line power operations, where workers, personal protective equipment (PPE), temporary insulation, and electrical structures appear under large-scale variation, occlusion, and bac...

Background: Type 2 diabetes mellitus (T2DM) and acute cerebral infarction (ACI) are globally prevalent diseases that impose substantial public health burdens. While gut microbiota (GM) is increasingly recognized to regulate metabolic and immune homeo...

Salmonella infection of chickens can cause persistent intestinal inflammation, intestinal microbiota disorder, and growth obstruction, which is an important bacterial disease causing significant economic losses in poultry farming. Phages, as an alter...

Objectives: This umbrella review synthesized and critically evaluated evidence from systematic reviews examining the effectiveness of Robot-Assisted Therapy (RAT) and Computerized Training (CT) for individuals with dementia and Mild Cognitive Impairm...

For robotic ultrasound targeting developmental dysplasia of the hip (DDH), reconstructed infant body-surface meshes should preserve the target surface while excluding bed, support, and background geometry. This study proposes a structured vision&ndas...

Background/Objectives: OFF episodes in Parkinson’s disease (PD) include motor and non-motor manifestations, but their resolution after on-demand therapy may not be synchronous. We examined within-patient temporal dynamics of motor and non-motor...

Chronic traumatic encephalopathy (CTE) is a progressive tauopathy associated with repetitive head impacts (RHIs) and is currently confirmed only at autopsy. The absence of a validated antemortem diagnostic limits individual risk assessment, clinical...

Background: High-load resistance training is the primary intervention to counteract sarcopenia; however, it may be contraindicated or poorly tolerated in some older adults. Low-load resistance training with blood flow restriction (LL-BFR) has been pr...

Nitrate, as a core component of water pollution, poses a severe threat to the ecological environment and human health. Electrochemical ammonia synthesis via nitrate reduction (NO₃RR) is a highly promising sustainable technology, yet the simultaneous...

Background/Objectives: To analyse trends in online information-seeking behaviour for five major cancers in Hungary, compare them with global trends, and assess changes during the COVID-19 pandemic, cancer-related awareness campaigns, and major cancer...

Background: Patient-reported outcome measures (PROMs) are important after hip fracture but can impose respondent burden. A simple global measure may provide complementary information about a patient’s overall perception of hip normality. The No...

Korea’s steel structure fabrication plant certification system requires applicants to submit a self-assessment form before certification assessment. This study evaluated the screening effectiveness of this mandatory self-assessment and its pote...

Artificial intelligence is widely used in network intrusion detection, but evidence regarding operational architecture remains fragmented across model families, fusion patterns, deployment environments, and evaluation practices. We conducted a PRISMA...

Pleuropulmonary blastoma (PPB) is a rare, paediatric, mesenchymal, pulmonary neoplasm that can be highly aggressive. To date, there are only two reports of PPB in animals. We describe the finding of pulmonary neoplasms with PPB-like features in two u...

Introduction: Surgical treatment for partial-thickness rotator cuff tendon (RCT) tears often involves open or arthroscopic conversion to a full-thickness tear. A novel method has been developed that utilizes sutureless bone-to-tendon fixation using a...

Background: Surface modification may influence tissue–implant interactions. This exploratory study compared the biomechanical, coating-integrity, and histological responses associated with uncoated titanium and carbon- or niobium-containing sur...

Background/Objectives: Breast cancer (BC), particularly aggressive subtypes such as triple-negative TNBC, remains a significant clinical challenge due to treatment resistance and therapeutic toxicity. This study evaluated the antitumor potential, ant...

Automated recognition of worker posture–structure relationships at scaffold platform edges is constrained by the scarcity of unsafe work-state images and bias associated with imaging conditions. We re-audited a single public dataset comprising...

Purpose: To investigate whether quantitative nuclear morphology from routine H&E images can be used as a biomarker for glioblastoma (GBM) biology and prognosis. Methods: Nuclear eccentricity, circularity, density, and heterogeneity were measured...

Background: Astrocytes play an important role in depression. However, their specific mechanisms, especially their subcellular mechanisms, remain unclear. Objective: We aimed to identify key genes associated with mitochondrial dynamics and astrocytes...