Exercise for Healthy Aging: Clinical Physiology, Functional Outcomes, and Implications for Clinical Practice
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Sports Medicine".
Deadline for manuscript submissions: 20 July 2026 | Viewed by 8
Special Issue Editors
Interests: physical activity; exercise physiology
Special Issues, Collections and Topics in MDPI journals
Interests: exercise; skeletal muscle; muscle physiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The global rise in population aging underscores the urgent need to understand how exercise supports healthy aging and preserves functional independence. While the benefits of physical activity are well established, the specific physiological and clinical mechanisms—ranging from molecular and mitochondrial adaptations to systemic and functional outcomes—remain incompletely defined.
This Special Issue aims to bring together current evidence and emerging research on the clinical physiology of exercise in older adults, emphasizing mechanisms of adaptation across multiple organ systems, the role of cardiorespiratory and neuromuscular fitness, and the connections between mitochondrial health, metabolic regulation, and physical function. We particularly welcome both experimental and clinical studies, as well as reports on novel assessment methods, rehabilitation strategies, and exercise interventions relevant to clinical practice.
By bridging foundational physiology with applied clinical perspectives, this Special Issue seeks to advance understanding, highlight research and practice gaps, and inform strategies to enhance healthspan, independence, and quality of life across the aging continuum.
Dr. Jerónimo Aragón-Vela
Dr. Rafael A. Casuso
Guest Editors
Manuscript Submission Information
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Keywords
- exercise
- healthy aging
- functional independence
- mitochondrial adaptations
- physical activity interventions
- neuromuscular function
- cardiorespiratory fitness
- metabolic health
- biomarkers of aging
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