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Exercise for Healthy Aging: Clinical Physiology, Functional Outcomes, and Implications...
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Exercise for Healthy Aging: Clinical Physiology, Functional Outcomes, and Implications for Clinical Practice

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Sports Medicine".

Deadline for manuscript submissions: 20 July 2026 | Viewed by 560

Special Issue Editors

Dr. Jerónimo Aragón-Vela

E-Mail Website
Guest Editor
Department of Health Sciences, Area of Physiology, Campus “Las Lagunillas”, Building B3, University of Jaen, 23071 Jaén, Spain
Interests: physical activity; exercise physiology
Special Issues, Collections and Topics in MDPI journals
Dr. Rafael A. Casuso

E-Mail Website
Guest Editor
Department of Health and Biomedical Sciences, Universidad Loyola Andalucía, Calle Escritor Castilla Aguayo, 4, Poniente Sur, 14004 Córdoba, Spain
Interests: exercise; skeletal muscle; muscle physiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The global rise in population aging underscores the urgent need to understand how exercise supports healthy aging and preserves functional independence. While the benefits of physical activity are well established, the specific physiological and clinical mechanisms—ranging from molecular and mitochondrial adaptations to systemic and functional outcomes—remain incompletely defined.

This Special Issue aims to bring together current evidence and emerging research on the clinical physiology of exercise in older adults, emphasizing mechanisms of adaptation across multiple organ systems, the role of cardiorespiratory and neuromuscular fitness, and the connections between mitochondrial health, metabolic regulation, and physical function. We particularly welcome both experimental and clinical studies, as well as reports on novel assessment methods, rehabilitation strategies, and exercise interventions relevant to clinical practice.

By bridging foundational physiology with applied clinical perspectives, this Special Issue seeks to advance understanding, highlight research and practice gaps, and inform strategies to enhance healthspan, independence, and quality of life across the aging continuum.

Dr. Jerónimo Aragón-Vela
Dr. Rafael A. Casuso
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • exercise
  • healthy aging
  • functional independence
  • mitochondrial adaptations
  • physical activity interventions
  • neuromuscular function
  • cardiorespiratory fitness
  • metabolic health
  • biomarkers of aging

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Published Papers (1 paper)

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Research

18 pages, 3471 KB  
Article
Associations Between Isometric Mid-Thigh Pull Peak Force and Functional and Cardiorespiratory Variables in Independent Older Women
by Jordan Hernandez-Martinez, Izham Cid-Calfucura, Pablo Valdés-Badilla, Pablo Merino-Muñoz, Esteban Aedo-Muñoz, Felipe Montalva-Valenzuela, Pedro Delgado-Floody, Cristian Núñez-Espinosa and Tomás Herrera-Valenzuela
J. Clin. Med. 2026, 15(10), 3858; https://doi.org/10.3390/jcm15103858 - 17 May 2026
Viewed by 217
Abstract
Background/Objectives: Muscle strength is a key determinant of functional capacity in older adults. However, measures such as handgrip strength may not fully reflect multi-joint force production, and the relevance of the Isometric Mid-Thigh Pull (IMTP) for functional and cardiorespiratory outcomes remains unclear. [...] Read more.
Background/Objectives: Muscle strength is a key determinant of functional capacity in older adults. However, measures such as handgrip strength may not fully reflect multi-joint force production, and the relevance of the Isometric Mid-Thigh Pull (IMTP) for functional and cardiorespiratory outcomes remains unclear. This study examined the associations between IMTP-derived peak force and functional and submaximal cardiorespiratory variables in independent older women. Methods: This cross-sectional study included 21 independent older women (72.6 ± 6.9 years). Maximal isometric strength (IMTP and handgrip), functional performance (TUG, 30-CST, 30-ACT), and submaximal cardiorespiratory variables were assessed. Associations were examined using Pearson’s correlation coefficients with false discovery rate (FDR) correction (q = 5%). Results: Absolute IMTP peak force was significantly related to handgrip strength (r = 0.77; q = 0.001) and PVT1 (r = 0.67; q = 0.007). Relative IMTP peak force was related to relative handgrip strength (r = 0.71; q = 0.002), VO2VT2 (r = 0.60; q = 0.02), and inversely to COP (r = −0.56; q = 0.03). No significant relationships were observed with TUG, 30-ACT, or most cardiorespiratory variables. Conclusions: IMTP-derived peak force was related to selected neuromuscular and submaximal cardiorespiratory variables, but not to functional performance measures. These findings suggest that the IMTP may provide complementary information on neuromuscular status, although further studies are required. Full article
(This article belongs to the Special Issue Exercise for Healthy Aging: Clinical Physiology, Functional Outcomes, and Implications for Clinical Practice)
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