Glioblastoma: Symptoms, Causes, Treatment and Prognosis

Dear Colleagues,

Glioblastoma remains the most aggressive and lethal primary brain tumor in adults, characterized by marked molecular heterogeneity, rapid progression, and inevitable recurrence despite multimodal therapy. Recent advances in molecular profiling, neuroimaging, and targeted therapeutic approaches have reshaped diagnostic and treatment paradigms, fostering more personalized and biology-driven management of this disease. Nevertheless, prognosis remains dismal, and innovative strategies are urgently needed to overcome therapeutic resistance and improve patient survival.

This Special Issue will provide an updated overview of current knowledge and emerging advances regarding the biology, clinical presentation, and management of glioblastoma. We welcome original research articles, comprehensive reviews, and clinical studies addressing molecular pathogenesis, prognostic and predictive biomarkers, novel therapeutic targets, immunotherapy, tumor microenvironment, radiomics, and patient-reported outcomes.

Dr. Giuseppe Lombardi
Guest Editor

Dr. Alberto Bosio
Guest Editor Assistant

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