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Advanced Biomaterials and Therapeutics for Bone Repair and Regeneration
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Advanced Biomaterials and Therapeutics for Bone Repair and Regeneration

A Special Issue of Journal of Functional Biomaterials (ISSN 2079-4983) belonging to the section "Bone Biomaterials".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 3180

Editors

Dr. Hemalatha Kanniyappan

E-Mail Website
Guest Editor
Department of Biomedical Engineering, University of Massachusetts Amherst, Amherst, MA 01002, USA
Interests: biomaterials; tissue engineering; drug delivery; biosensors
Dr. Srirangam Ramanujam Vaibavi

E-Mail Website
Guest Editor
School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Ave, Singapore 639798, Singapore
Interests: tissue engineering; cell mechanics; preclinical studies

Special Issue Information

Dear Colleagues,

Bone repair and regeneration remain persistent challenges in orthopedics and regenerative medicine. Despite advancements in surgical techniques and biomaterials, many current approaches still face limitations, including poor host integration, inadequate vascularization, and insufficient mechanical performance.

This Special Issue, “Advanced Biomaterials and Therapeutics for Bone Repair and Regeneration”, sets itself apart from other collections by emphasizing three key aspects:

  1. Focus on Functional Integration: Rather than considering biomaterials in isolation, we highlight strategies that simultaneously promote osteogenesis, angiogenesis, and immune modulation to achieve long-term functional success.
  2. Bridging Basic Science and Clinical Translation: Unlike prior issues that concentrate heavily on in vitro studies, this Special Issue actively encourages preclinical and clinical submissions, showcasing how laboratory discoveries can be adapted into real-world therapeutic interventions.
  3. Multidisciplinary Collaboration with Targeted Contributions: Beyond general interdisciplinary insights, we aim to invite leading researchers whose work demonstrate translational impact in areas such as 3D bioprinting, nanostructured scaffolds, drug/gene delivery systems, and bioactive bone grafts.

The scope of this Special Issue includes advanced natural polymers, synthetic scaffolds, and hybrid nanocomposites, as well as emerging fabrication methods such as 3D bioprinting, micro/nanostructured platforms, and controlled delivery systems. By integrating knowledge from the fields of biomaterials science, biomedical engineering, and clinical orthopedics, it aims to accelerate the development of next-generation solutions for bone repair.

This Special Issue will distinguish itself by offering both innovative concepts and clinically relevant perspectives that bridge the gap between bench and bedside. We welcome original research, reviews, and perspectives that contribute to this translational vision.

Dr. Hemalatha Kanniyappan
Dr. Srirangam Ramanujam Vaibavi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone regeneration
  • translational research
  • bioactive scaffolds
  • angiogenesis and osteogenesis
  • 3D bioprinting

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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36 pages, 7147 KB  
Article
Standardized Photobiomodulation Dosimetry Targeting the Base of Calvarial Critical-Sized Defects for Bone Regeneration: A Preclinical RCT Comparing Flattop vs. Gaussian Beam Profiles, with or Without Bio-Oss®
by Reem Hanna, Wayne Selting, Vincenzo Cuteri, Giacomo Rossi, Alessandro Bosco, Laura Emionite, Michele Cilli, Emanuela Marcenaro, Federico Rebaudi, Marco Greppi and Stefano Benedicenti
J. Funct. Biomater. 2026, 17(3), 125; https://doi.org/10.3390/jfb17030125 - 4 Mar 2026
Cited by 1 | Viewed by 1900
Abstract
Photobiomodulation (PBM) has shown promising potential to enhance bone regeneration; however, its optimal delivery parameters and interactions with osteoconductive scaffolds remain insufficiently defined. This preclinical study is the first to incorporate a pilot dosimetry evaluation to standardize 980-nm PBM delivery and ensure that [...] Read more.
Photobiomodulation (PBM) has shown promising potential to enhance bone regeneration; however, its optimal delivery parameters and interactions with osteoconductive scaffolds remain insufficiently defined. This preclinical study is the first to incorporate a pilot dosimetry evaluation to standardize 980-nm PBM delivery and ensure that effective irradiance reached the target surface of critical-size calvarial defects in mice. The primary aim was to evaluate the effectiveness of this novel 980-nm PBM protocol delivered using either flat-top (FT) or standard Gaussian (ST) handpieces in enhancing bone regeneration in critical-size defects (CSDs), both with and without Bio-Oss® grafting. A total of 120 adult mice were allocated into twelve experimental groups (n = 10 per group): untreated (control), Bio-Oss® alone, PBM alone, and PBM combined with Bio-Oss®, using either FT or ST handpieces, and evaluated at 30 and 60 days. Animals received 980 nm irradiation at 0.6 W (nominal power output–set on laser interface) in continuous-wave mode for 60 s, three times per week, for two consecutive weeks. Pilot dosimetry included power meter measurements to determine the therapeutic power reaching the defect surface area and temperature monitoring to ensure safe energy delivery. The dosimetry study demonstrated that, after accounting for the optical properties of mouse shaved skin and the Bio-Oss® graft covered with Bio-Gide® membrane, the effective irradiance reaching the base of the defect surface area was 1.131 W/cm2 for the FT handpiece and 0.413 W/cm2 for the ST handpiece. This dose was sufficient to induce significant regenerative effects. Histological, Masson’s trichrome, and immunohistochemical analyses for Runx2, OCN, GLI1, CD34, and CTSK were performed to characterize early and late osteogenic events. The combination of PBM and Bio-Oss® significantly accelerated bone regeneration compared with PBM alone, with the FT handpiece producing the most uniform and advanced osteogenesis. PBM enhanced progenitor activation, osteoblast differentiation, angiogenesis, matrix deposition, and late-stage remodeling, demonstrating a synergistic effect with the scaffold, whereas Bio-Oss® alone or defect alone showed limited early regenerative potential. These findings highlight the effectiveness of this novel standardized PBM dosimetry and uniform beam profile (FT), supporting their use as a foundation for future randomized controlled trials in craniofacial bone repair. Full article
(This article belongs to the Special Issue Advanced Biomaterials and Therapeutics for Bone Repair and Regeneration)
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Review

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25 pages, 7845 KB  
Review
Engineering Smart Scaffolds for Osteomyelitis: Integrating Nanotechnology, Drug Delivery, and Tissue Regeneration—A Narrative Review
by Chayse Baker, Caleb Jolley, Ian Alexander, Elijah Lee, Hemalatha Kanniyappan and Aftab Merchant
J. Funct. Biomater. 2026, 17(8), 379; https://doi.org/10.3390/jfb17080379 - 3 Aug 2026
Viewed by 708
Abstract
Osteomyelitis is a severe, progressive bone infection affecting approximately 21.8 per 100,000 individuals in the United States and remains a major challenge in orthopedic and reconstructive medicine. Staphylococcus aureus (S. aureus), responsible for nearly 75% of cases, is the most common [...] Read more.
Osteomyelitis is a severe, progressive bone infection affecting approximately 21.8 per 100,000 individuals in the United States and remains a major challenge in orthopedic and reconstructive medicine. Staphylococcus aureus (S. aureus), responsible for nearly 75% of cases, is the most common causative pathogen. Current gold-standard management involves culture-directed antibiotic therapy administered for 4–6 weeks, often combined with surgical debridement and the use of antibiotic-loaded cement spacers. Despite these interventions, treatment frequently fails to achieve complete infection eradication, with recurrent or persistent disease reported in up to 40% of cases, contributing to chronic inflammation, impaired bone healing, and long-term functional deficits. These limitations highlight the need for therapeutic strategies that address infection control and bone regeneration. A narrative literature review was conducted to evaluate emerging tissue-engineered scaffold-based biomaterials as potential alternatives to conventional treatment. Emerging evidence suggests antimicrobial-loaded matrices, bioactive scaffolds, and stimuli-responsive biomaterials can provide localized drug delivery, structural support, and enhanced osteogenesis while improving infection control and osteointegration. Advances in targeted drug delivery, immunomodulatory biomaterials, and computational scaffold design further suggest opportunities for more effective therapies. These findings highlight the potential of scaffold-based biomaterials to improve osteomyelitis management, although further clinical studies are required. Full article
(This article belongs to the Special Issue Advanced Biomaterials and Therapeutics for Bone Repair and Regeneration)
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