Personalized Medicine: Integrating Pharmacogenetics and Pharmacokinetics

Dear Colleagues,

In recent years, personalized medicine has become a sub-area of great interest within medicine due to the variability in therapeutic responses observed among individuals. We know that before a drug reaches its site of action and/or exerts a pharmacological effect it is often metabolized by drug-metabolizing enzymes and may be transported by the solute carrier family and/or ATP-binding cassette (ABC) family proteins, and that changes in these processes can lead to variations in drug kinetics and, therefore, in the responses of individuals subjected to the same medications. Furthermore, alterations in the process of metabolization and the transport of drugs as well as their metabolites are highly likely due to variations in the genes that encode these enzymes and transporters. Thus, the integration of genetic and pharmacokinetic data from individuals with a pathological condition and subjected to a specific drug becomes a promising strategy for adjusting drug dosage to minimize the risk of adverse effects and optimize therapeutic responses. This Special Issue aims to highlight all types of articles, including original research and reviews, that may contribute to the growth of personalized medicine based on the integration of pharmacogenetics and pharmacokinetics, thereby enabling crucial advances in healthcare with more effective and safer treatments tailored to an individual.

Dr. Sétondji Cocou Modeste Alexandre Yahouédéhou
Prof. Dr. Elżbieta Wyska
Guest Editors

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