The lateral line organ of fish has inspired engineers to develop flow sensor arrays—dubbed artificial lateral lines (ALLs)—capable of detecting near-field hydrodynamic events for obstacle avoidance and object detection. In this paper, we present a co...
L-Arginine, a semi-essential amino acid, was shown to delay dysfunction of motor neurons and to prolong the lifespan, upon analysis of transgenic mouse models of amyotrophic lateral sclerosis (ALS). We investigated the transport function of arginine...
Fish sense water motions with their lateral line. The lateral line is a sensory system that contains up to several thousand mechanoreceptors, called neuromasts. Neuromasts occur freestanding on the skin and in subepidermal canals. We developed arrays...
This paper introduces the near-field detection system of an underwater robot based on the fish lateral line. Inspired by the perception mechanism of fish’s lateral line, the aim is to add near-field detection functionality to an underwater vehi...
Inspired by the lateral line system of fish, an artificial lateral line system based on bionic hair sensor with resonant readout is presented in this paper. An artificial lateral line system, which possesses great application potential in the field o...
Acute chemical ablation of lateral line hair cells is an important tool to understand lateral line-mediated behaviors in free-swimming fish larvae and adults. However, lateral line-mediated behaviors have not been described in fish larvae prior to sw...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive degeneration of upper and lower motor neurons. While monogenic causes account for a minority of cases, in most cases, ALS is sporadic and likely...
The lateral line system is an essential mechanosensory organ for organisms such as fish; it perceives the fluid environment in the near-field through the neuromasts on the lateral line system, supporting behaviors (e.g., obstacle avoidance and predat...
In nature, the lateral line of fish is a peculiar and important organ for sensing the surrounding hydrodynamic environment, preying, escaping from predators and schooling. In this paper, by imitating the mechanism of fish lateral canal neuromasts, we...
This paper is based on the fish lateral line sensing mechanism and aims to determine the coupling relationship between the flow field sensing signal and target source position information. Firstly, according to the flow field distribution characteris...
Cisplatin is an effective anticancer agent, but also causes permanent hearing loss by damaging hair cells—the sensory receptors essential for hearing. There is an urgent clinical need to protect cochlear hair cells in patients undergoing cispla...
At present, autonomous underwater vehicles (AUVs) cannot perceive local environments in complex marine environments, where fish can obtain hydrodynamic information about the surrounding environment through a lateral line. Inspired by this biological...
The lateral line system in fish is crucial for detecting water flow, which facilitates various behaviors such as prey detection, predator avoidance, and rheotaxis. The cupula, a gelatinous structure overlaying the hair cells in neuromasts, plays a ke...
The motion-control precision of a shallow-sea underwater robot is seriously affected by external disturbances such as wind, waves and ocean currents. Due to the lack of a specialized disturbance-sensor system, the disturbance force and torque cannot...
Unmet needs remain in later lines chronic myeloid leukemia (CML): the response rate and the overall survival of resistant patients in the chronic phase who changed a second-generation TKI in the second line with another TKI with similar action are us...
Surface mounted ‘smart skin’ can enhance the situational and environmental awareness of marine vehicles, which requires flexible, reliable, and light-weight hydrodynamic pressure sensors. Inspired by the lateral line canal system in fish, we develope...
The lateral line is a highly differentiated skin sensory organ in fish, but few studies have explored the relationship between stocking density and the physiological responses of the lateral line in different species. In this study, grass carp, turbo...
The multi-sensor artificial lateral line system (ALLS) can identify the flow-field’s parameters to realize the closed-loop control of the underwater robotic fish. An inappropriate sensor placement of ALLS may result in inaccurate flow-field parametri...
Fish and some amphibians can perform a variety of behaviors in confined and harsh environments by employing an extraordinary mechanosensory organ, the lateral line system (LLS). Inspired by the form-function of the LLS, a hydrodynamic artificial velo...
Mastic essential oil exhibits anti-bacterial, anti-inflammatory, and anti-oxidant properties. With the growing interest of the use of mastic oil in the food and pharmaceutical industry, systematic in vivo studies are needed to address controlled usag...
Basic helix–loop–helix (bHLH) transcription factors, such as those in the atonal family, are important in cellular fate determination. The expression of the sponge ortholog of the atonal bHLH gene family, AmqbHLH1, in Xenopus laevis previ...
A vigorous root system in barley promotes water uptake from the soil under water-limited conditions. We investigated three spring barley genotypes with varying water stress responses using rhizoboxes at the seedling stage. The genotypes comprised two...
High motional resistance and incompatibility with post-CMOS fabrication due to thermal budget constraints are imperative issues associated with the back-end-of-line integration of lateral extensional vibrating micromechanical resonators. This paper p...
Hydrodynamic pressure sensors offer an auxiliary approach for ocean exploration by unmanned underwater vehicles (UUVs). However, existing hydrodynamic pressure sensors often lack the ability to monitor subtle hydrodynamic stimuli in deep-sea environm...
Piezo proteins have been identified as mechanosensitive ion channels involved in mechanotransduction. Several ion channel dysfunctions may be associated with diseases (including deafness and pain); thus, studying them is critical to understand their...
Amyotrophic lateral sclerosis (ALS) consists of the progressive degeneration of motor neurons, caused by poorly understood mechanisms for which there is no cure. Some of the cellular perturbations associated with ALS can be detected in peripheral cel...
The driving and resistance torques of some rotating machinery for industrial applications are nonstationary and affect system dynamics. Under such operating conditions, coupling between torsional and lateral vibrations may become significant for driv...
Background: The development of later-line drugs for metastatic colorectal cancer (mCRC) has expanded treatment options. However, real-world evidence of treatment sequences and transition rates from early- to later-line treatments are limited. Patient...
The artificial lateral line sensing principle provides a promising approach for underwater target perception and the navigation of underwater vehicles in complex flow environments. However, the highly nonlinear hydrodynamic mechanisms in complex flow...
The high-precision dynamic positioning of highway vehicles is the foundation and prerequisite for achieving intelligent connected transportation. To address the shortcomings of the GNSS/INS combination and GNSS/INS/OD combination in tunnel vehicle po...
The line field (LF) design choice for the lateral image formation mechanism (lateral format) has historically been a fraction of the whole optical coherence tomography (OCT) field. However, as the OCT technology develops, the parallelised acquisition...
Neuromast cells are specialized mechanosensory receptor cells embedded within the lateral line system of aquatic vertebrates, enabling the detection of water movement and vibration that are essential for navigation, prey capture, and predator avoidan...
Despite the ever-increasing role of pesticides in modern agriculture, their deleterious effects are still underexplored. Here we examine the effect of A6, a pesticide derived from the naturally-occurring α-terthienyl, and structurally related to the...
Defective solute carrier (SLC) transporters are responsible for neurotransmitter dysregulation, resulting in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). We provided the role and kinetic parameters of transporters such as A...
Paeonol is a naturally occurring phenolic agent that attenuates neurotoxicity in neurodegenerative diseases. We aimed to investigate the antioxidant and protective effects of paeonol and determine its transport mechanism in wild-type (WT; NSC-34/hSOD...
In recent years, variable rejuvenation techniques, such as hyaluronic acid (HA) fillers and radiofrequency (RF) devices, have become popular. We evaluated the RF hydro-injector (RFHI) device that simultaneously delivers both a microneedle intradermal...
This study examines the distinct roles of the neural cell adhesion molecules Ncam1a and Ncam1b in zebrafish neuromasts during both homeostasis and hair cell regeneration. While both molecules contribute to the initial development of the lateral line...
L-Carnitine (LC) is essential for transporting fatty acids to the mitochondria for β-oxidation. This study was performed to examine the alteration of the LC transport system in wild type (WT, NSC-34/hSOD1WT) and mutant type (MT, NSC-34/hSOD1G93A) amy...
A new method based on the interferometric pseudo-lateral-shearing method is proposed to evaluate the pitch variation of a large-scale planar variable-line-spacing (VLS) grating. In the method, wavefronts of the first-order diffracted beams from a pla...
Choline, a component of the neurotransmitter acetylcholine, is essential for nervous system functions, brain development, and gene expression. In our study, we investigated the protective effect and transport characteristics of choline in amyotrophic...
Root intrusion into emitters poses a threat to the lifespan of subsurface drip irrigation systems. In an attempt to address this problem, an experiment was conducted on spring wheat (Mengmai 30) grown in soil columns installed in a greenhouse to stud...
Control of canine infections with Leishmania infantum (L. infantum), a major zoonotic disease in Brazil and southern Europe, is becoming increasingly important due to its close proximity to humans, the increasing import of dogs from endemic regions a...
Non-line-of-sight (NLOS) communication with severe loss always leads to performance degradation in unmanned aerial vehicle (UAV) payload communication. In this paper, a UAV NLOS communication scheme based on single-carrier frequency domain equalizati...
Electrostatic discharge (ESD) events can severely damage miniature components. Therefore, ESD protection is critical in integrated circuits. In this study, drain-electrode-embedded horizontal Schottky diode contact modulation and Schottky length redu...
Neurotrophins (NTs) and their signal-transducing Trk receptors play a crucial role in the development and maintenance of specific neuronal subpopulations in nervous and sensory systems. NTs are supposed to regulate two sensory systems in fish, the in...
Sensory hair cells are the receptors for auditory, vestibular, and lateral line sensory organs in vertebrates. These cells are distinguished by “hair”-like projections from their apical surface collectively known as the hair bundle. Along...
The acoustic hypothesis suggests that schooling can result in several benefits. (1) The acoustic pattern (AP) (pressure waves and other water movements) produced by swimming are likely to serve as signals within fish shoals, communicating useful spat...
Four sensory systems (vestibular, lateral line, electroreception, auditory) are unique and project exclusively to the brainstem of vertebrates. All sensory neurons depend on a common set of genes (Eya1, Sox2, Neurog1, Neurod1) that project to a dorsa...
An electrostatic discharge (ESD) event can negatively affect the reliability of integrated circuits. Therefore, improving on ESD immunity in high-voltage (HV) n-channel (n) lateral diffused metal–oxide–semiconductor field-effect transisto...
Background: A concern about kinematically aligned (KA) total knee arthroplasty (TKA) is that it relies on femoral components designed for mechanical alignment (MAd-FC) that could affect patellar tracking, in part, because of a trochlear groove orient...
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