Modeling Neurogenesis, Regeneration and Disease from Animal Models
A Special Issue of International Journal of Molecular Sciences (ISSN 1422-0067) belonging to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 September 2026 | Viewed by 2060
Editors
2. Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D’Alcontres 31, 98166 Messina, Italy
Interests: zebrafish; nothobranchius; sensory system; ageing; growth
Interests: morphometry; veterinary anatomy; zebrafish; imaging; experimental model; natural compounds; obesity; immunohistochemistry; molecular biology; sensory system; regeneration of sensory cells
Special Issues, Collections and Topics in MDPI journals
Interests: gene regulation; transcription; neurogenesis; zebrafish; regeneration; neural stem cell
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurogenesis and neural regeneration are central to nervous system development, plasticity, and repair. These processes are regulated by complex molecular signalling pathways, cellular interactions, and structural changes at both tissue and subcellular levels. Disruptions to these processes contribute to a wide spectrum of conditions, including impaired neurogenesis, failed regeneration, neurodevelopmental syndromes, traumatic injuries, and age-associated diseases.
Animal models have been essential for advancing our understanding of the molecular, cellular, and structural mechanisms governing neurogenesis, neural regeneration, and disease progression. Comparative analyses of conserved and divergent pathways, together with the identification of homologous neural structures and cell types, provide powerful in vivo systems for studying neural function, repair, and pathology.
Recent technological advances integrating molecular biology, omics-based approaches, genome editing, imaging, and computational analysis now allow researchers to directly link molecular changes with cellular architecture, tissue organization, and functional outcomes in both development and disease.
We invite researchers to contribute to this Special Issue, which aims to present research using animal models to investigate the molecular and structural bases of neurogenesis, neural regeneration, and neurological disease. By integrating multidisciplinary approaches, this Special Issue will bridge molecular insights with structural and functional outcomes, strengthening the translational relevance of animal-based neuroscience research.
In this Special Issue, original research articles and reviews are welcome. Contributions may address (but are not limited to) the following:
- Signalling pathways involved in neural regeneration and repair;
- Translational insights linking molecular and ultrastructural changes to neurological disorders;
- Animal models of neurodevelopmental and neurodegenerative diseases;
- Modelling brain injury, spinal cord injury, and neural repair;
- Role of inflammation, metabolism, and the microenvironment in neural regeneration.
We look forward to receiving your contributions.
Dr. Kamel Mhalhel
Dr. Giuseppe Montalbano
Dr. Sepand Rastegar
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- neurogenesis
- neural regeneration
- animal models
- neural stem cells
- neurodevelopment
- neurodegeneration
- molecular mechanisms
- disease modeling
- nervous system repair, ultrastructure
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