Zebrafish: A Model for Toxicological Research

Dear Colleagues,

The zebrafish (Danio rerio) has long been used as a model species for the toxicity testing of chemicals. The zebrafish, however, offers considerably more as a model species and is now used in many different research fields including basic developmental biology, neurobiology, and immunology. Advances in genetic and epigenetic research of the zebrafish, including gene knockout and transgenesis technologies, allow for better understanding of molecular mechanisms of toxic action. The potential of zebrafish for modeling human diseases is becoming increasingly evident, and the availability of these models allows for increased understanding of the role of chemical exposure in human disease. In this Special Issue, we welcome contributions that show recent developments in zebrafish toxicity testing and drug discovery, such as novel endpoints, assays and testing strategies. Articles covering aspects of molecular and cellular mechanisms of action to effects on individual fish as well as multigenerational effects and population level impacts are invited. Contributions on high throughput screening, monitoring and safety assessment of chemicals are invited, as well as new insights on the effects in chemical exposure in zebrafish models of human diseases. Translational studies that employ molecular methods to enhance our understanding of human health or environmental risk assessment are also of interest.

Prof. Dr. Juliette Legler
Guest Editor

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