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Special Issue "Biological Activities of Medicinal Plants"
Deadline for manuscript submissions: 10 April 2020.
Interests: essential oils; natural product; biological activity; GC–MS characterization; antioxidant activity; polyphenols determination; phytotoxic activity; secondary metabolites
Special Issues and Collections in MDPI journals
Dr. Laura De Martino
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- medicinal plants
- secondary metabolites
- natural compounds
- biological activities
- bioactive compounds
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Antiestrogenic activity of Guajadial fraction, from Guava Leaves (Psidium guajava L.)
Authors: Jaqueline Bazioli
Affiliation: Institute of Chemistry, Universidade Estadual de Campinas, CP 6154, 13083-970 Campinas, SP, Brazil
Abstract: The research of natural products has allowed the discovery of biologically relevant compounds inspired by plant secondary metabolites, which contributes to the development of many chemotherapeutic drugs used in cancer treatment. Around 75% of anticancer drugs are derived from natural products, showing the great potential of such products in new drug research and development for the treatment of this set of diseases. Psidium guajava leaves present a diverse phytochemical composition including flavonoids, phenolics, meroterpenoids and triterpenes as the major bioactive constituents. In particular, guajadial, a caryophyllene-based meroterpenoid, has been studied for its potential anticancer effects in tumor cells and in experimental models with laboratory animals. However, little information has been reported about the role and mechanism of action of guajadial in tumor inhibition. This study evaluated the antiproliferative activity and anti-estrogenic action of an active fraction obtained from the Psidium guajava L. containing guajadial as principal active compound. Fraction containing guajadial were obtained by chromatographic techniques and showed promising antiproliferative activity in vitro with selectivity for human breast cancer cell lines MCF-7 and MCF-7 BUS (TGI = 5,59 and 2.27 mg/mL, respectively). Also, evaluation of anti-estrogenic activity in vivo was realized demonstrating that Guajadial fraction was able to block the proliferative effect of estradiol on the uterus rats pre-pubescent. These results suggest a correlation between the antiproliferative and the anti-estrogenic activity of Guajadial, which possibly acts in tumor inhibition through estrogen receptors due to its structural similarity.