The Maize Wip1 gene encodes a wound-induced Bowman-Birk inhibitor (BBI) protein which is a type of serine protease inhibitor, and its expression is induced by wounding or infection, conferring resistance against pathogens and pests. In this study, th...
Our previous study demonstrated that ovarian wild-type P53-induced phosphatase 1 (WIP1) expression decreased with age. We hypothesized that WIP1 activity was related to ovarian aging. The role of WIP1 in regulating ovarian aging and its mechanisms re...
In acute myeloid leukemia (AML), the restoration of p53 activity through MDM2 inhibition proved efficacy in combinatorial therapies. WIP1, encoded from PPM1D, is a negative regulator of p53. We evaluated PPM1D expression and explored the therapeutic...
As there is no optimal therapeutic strategy defined for women with advanced or recurrent uLMS, there is an urgent need for the discovery of novel, targeted approaches. One such area of interest is the pharmacological inhibition of the MDM2-p53 intera...
Actin polymerization is a fundamental cellular process regulating immune cell functions and the immune response. The Wiskott-Aldrich syndrome protein (WASp) is an actin nucleation promoting factor, which is exclusively expressed in hematopoietic cell...
Background: Intrahepatic cholangiocarcinoma (iCCA) is an adenocarcinoma arising from the intrahepatic bile duct. It is the second most common primary liver cancer and has a poor prognosis. Activation of p53 by targeting its negative regulators, MDM2...
Phosphorylation of H2AX on Ser139 (γH2AX) after exposure to ionizing radiation produces nuclear foci that are detectable by immunofluorescence microscopy. These so-called γH2AX foci have been adopted as quantitative markers for DNA double-strand bre...
The WIP family of transcription factors comprises the A1d subgroup of C2H2 zinc finger proteins. This family has six members in Arabidopsis thaliana and most of the known functions have been described by analyzing single knockout mutants. However, it...
Rubus idaeus is one of the primary cultivated species of raspberries, renowned for its appealing color, distinctive flavor and numerous health benefits. WIP proteins, which contain three conserved amino acids (W: Tryptophan, I: Isoleucine, P: Proline...
Wild-type p53 (wtp53) is described as a tumour suppressor gene, and mutations in p53 occur in many human cancers. Indeed, in high-grade malignant glioma, numerous molecular genetics studies have established central roles of RTK-PI3K-PTEN and ARF-MDM2...
Background/Objectives: Soybean (Glycine max) productivity is increasingly constrained by soil salinity. WIP transcription factors, a subfamily of C2H2-type zinc finger proteins, regulate cell division, differentiation, and tissue patterning in severa...
Genotoxic stress triggers a combined action of DNA repair and cell cycle checkpoint pathways. Protein phosphatase 2C delta (referred to as WIP1) is involved in timely inactivation of DNA damage response by suppressing function of p53 and other target...
Discrete manufacturing environments face increasing challenges in managing work-in-process (WIP) inventory due to growing product customization and demand volatility. While Value Stream Mapping (VSM) has been widely used for process improvement, trad...
The Ouenza open-pit mine is one of Algeria’s major iron ore producers, where efficient blasting and fragmentation control are essential to maintaining stable, productive mining operations. The primary objective of this study is to quantitativel...
Additively manufactured fibre-reinforced polymers are gaining traction. After the development and optimisation of a novel fibre-deposition system in a laser sintering (LS) setup, polyamide 12 specimens were produced with and without glass fibres. In...
Effective production control requires aligning strategic planning with real-time execution under dynamic and stochastic conditions. This study proposes a scalable dual-agent Deep Reinforcement Learning (DRL) framework for the joint optimisation of Wo...
Blast charge initiation procedures have a significant impact on both mining safety and production rates. In this study, the inventory benefit of an electric initiation system was investigated to assess its influence on both fragmentation and blast-in...
Permutation flowshop design and optimization are crucial in industry as they have a direct impact on production scheduling and efficiency. The ultimate goal is to model the production system (PSM) based on revealing the fundamental principles of the...
Childhood medulloblastoma and high-risk neuroblastoma frequently present with segmental gain of chromosome 17q corresponding to aggressive tumors and poor patient prognosis. Located within the 17q-gained chromosomal segments is PPM1D at chromosome 17...
WASp-interacting protein (WIP), a regulator of actin cytoskeleton assembly and remodeling, is a cellular multi-tasker and a key member of a network of protein–protein interactions, with significant impact on health and disease. Here, we attempt...
Due to their high metabolic rate, tumor cells produce exacerbated levels of reactive oxygen species that need to be under control. Wiskott–Aldrich syndrome protein (WASP)-interacting protein (WIP) is a scaffold protein with multiple yet poorly...
One of the main problems of modern manufacturing systems is the increasing complexity related to modern Industry 4.0 technologies that are fundamentally changing manufacturing and logistics processes and operations. Industry 4.0 includes, e.g., flexi...
Ionizing radiation triggers diverse responses in human cells encompassing apoptosis, necrosis, stress-induced premature senescence (SIPS), autophagy, and endopolyploidy (e.g., multinucleation). Most of these responses result in loss of colony-forming...
The Evil Twin attack, which involves creating rogue Wi-Fi access points that impersonate legitimate networks, remains one of the most persistent and adaptive threats in cybersecurity, despite more than two decades having passed since its first public...
Multiple myeloma (MM) first-line treatment algorithms include immuno-chemotherapy (ICT) induction, high-dose chemotherapy (HDCT) and autologous stem cell transplant (ASCT) consolidation, followed by lenalidomide maintenance. After these initial thera...
Chimeric antigen receptor T (CAR T)-cell therapy has become a standard treatment option for patients with relapsed or refractory diffuse large B-cell lymphoma (r/r DLBCL). Mutations in the PPM1D gene, a frequent driver alteration in clonal hematopoie...
There are some important advantages presented by metal specimens coated with WIP-C1 (Ni/CrC)-type materials. However, given the coating methods and the stress under dynamic loads, there are issues that need to be taken into account, particularly in t...
Fatigue behavior of standardized 4340 steel samples uniformly coated with WIP-C1 (Ni/CrC) by cold spray was investigated. In particular, when a crack appeared at the interface between the base material and the coating, the cause of it as well as its...
Monitoring urban compositions spatially and temporally is a crucial issue for urban planning and management. Nowadays, remote sensing techniques have been widely applied for urban compositions extraction. Compared with other remote sensing techniques...
Plant small peptides are critical regulators of various biological processes, including development and stress responses. Polypeptides within the DUF3774 family, known as wound-induced polypeptides (WIPs), have been identified as key players in patte...
People are interested in traveling in an infinite virtual environment, but no standard navigation method exists yet in Virtual Reality (VR). The Walking-In-Place (WIP) technique is a navigation method that simulates movement to enable immersive trave...
The accurate cycle time (CT) prediction of the wafer fabrication remains a tough task, as the system level of work in process (WIP) is fluctuant. Aiming to construct one unified CT forecasting model under dynamic WIP levels, this paper proposes a tra...
Geopolymer (GP) has been applied as an environmentally-friendly construction material in recent years. Many pozzolanic wastes, such as fly ash (FA) and bottom ash, are commonly used as source materials for synthesizing geopolymer. Nonetheless, many n...
Chronic myeloid leukemia (CML) is recognized as a classic clonal myeloproliferative disorder. Given the limited treatment options for CML patients in the accelerated phase (AP) and blast phase (BP), there is an evident need to develop new therapeutic...
In the original publication [...]
This work investigates the relationship between the parastrophes of some notion of inverses in quasigroups. Our findings reveal that, of the 5 parastrophes of LIP quasigroup, (23) parastrophe is a LIP quasigroup, (12) and (132) parastrophes are RIP q...
Recently, the well-industry-production-scheme (WIPS) has attracted more and more attention to improve tight oil recovery. However, multi-well pressure interference (MWPI) induced by well-industry-production-scheme (WIPS) strongly challenges the tradi...
Germline alterations in many genes coding for proteins regulating DNA repair and DNA damage response (DDR) to DNA double-strand breaks (DDSB) have been recognized as pathogenic factors in hereditary cancer predisposition. The ATM-CHEK2-p53 axis has b...
The accurate determination of the porosity and specific surface area of porous materials such as shale and cement plays a key role in gas-energy-storage estimation and exploitation, building-heat and humidity-transfer investigation, and permeability-...
Growing global concerns over reducing carbon emissions in the electricity market have accelerated the integration of renewable energy sources and electric vehicles, increasing variabilities and uncertainties across various nodes of power networks. Sy...
Background/Objectives: Mantle cell lymphoma (MCL) represents a rare B-cell lymphoma subtype with rather high relapse rates. Somatic mutations in the PPM1D gene were shown to be associated with adverse outcomes in patients with diffuse large B-cell ly...
Anticancer strategies targeting the DNA damage response are largely centered on a number of false hypotheses. For example, engaging apoptosis in solid tumors is universally assumed to represent a tumor suppression response. But what is “apoptos...
Material extrusion (ME) using a filament including metal powders has recently attracted considerable attention because it allows the production of metal parts at low cost. However, like other additive manufacturing processes, metal ME suffers from th...
23 July 2022
The aim of this pilot study was to assess the time-related changes in viable nasal bacteria concentrations among waste-incineration plant (WIP) workers compared to a group of office building (OB) workers outside the plant. In total, 20 volunteers par...
Continuous cost reduction is a subject of interest for almost every production company. The cost reflects the competitiveness and sustainability of the business. Many company costs are linked to the effectiveness of production. One such cost is the w...
Since last decade, the cluster tool has been mainstream in modern semiconductor manufacturing factories. In general, the cluster tool occupies 60% to 70% of production machines for advanced technology factories. The most characteristic feature of thi...
In the solar silicon manufacturing industry, the production time for crystal growth is ten times longer than at other workstations. The pre-processing time at the ingot-cutting station causes work-in-process (WIP) accumulation and an excessively long...
In-flight icing for aircraft is a large concern for all those involved in aircraft operations. Generally, an electric heater has been used to prevent in-flight icing. A hybrid anti-icing system combining ice-phobic coating and electrothermal heating...
Nowadays, quickly changing customer demands are a big challenge in the manufacturing industry, especially for job shops, which are typical coupling and nonlinear multi-input–multi-output (MIMO) systems. In order to achieve good shop floor perfo...
Forests’ conversion to tea plantations is a land use transition type with high economic value in China. How this conversion affects soil weathering and nutrient characteristics remains unclear. Here, we selected six soil profiles (three pairs)...
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