Special Issue "The Amazing World of IDPs in Human Diseases"

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 15 October 2020.

Special Issue Editors

Dr. Simona Maria Monti
E-Mail Website
Guest Editor
Biostructure and Bioimaging Institute-CNR, Via Mezzocannone 16, 80134 Naples, Italy
Interests: chemical biology; structural and functional characterization of proteins and bioactive peptides; intrinsically disordered proteins; carbonic anhydrases; protein biophysics; cancer biology; protein-protein, protein-DNA interaction studies; cancer-related proteins; non enzymatic glycation and AGEs; oxidative stress
Dr. Giuseppina De Simone
E-Mail Website
Guest Editor
Biostructure and Bioimaging Institute-CNR, Via Mezzocannone 16, 80134 Naples, Italy
Interests: structural characterization of proteins; structural characterization of protein–ligand complexes; X ray crystallography; rational drug design; protein bioinformatics; carbonic anhydrase; cancer-related proteins
Dr. Emma Langella
E-Mail Website
Guest Editor
Biostructure and Bioimaging Institute-CNR, Via Mezzocannone 16, 80134 Naples, Italy
Interests: computational chemistry; molecular dynamics simulations; modeling; protein-ligand docking; protein-protein docking; computer-aided drug design; binding free energy calculations; intrinsically disordered proteins; carbonic anhydrases; oligonucleotides; Alzheimer-related proteins; cancer-related proteins

Special Issue Information

Dear Colleagues,

It is now clearly established that some proteins or protein regions are devoid of any stable secondary and/or tertiary structure under physiological conditions, but still possess fundamental biological functions. These intrinsically disordered proteins (IDPs) or regions (IDRs) have peculiar features due to their plasticity as the capacity of binding their biological targets with high specificity and low affinity, and the possibility of interaction with numerous partners. IDPs and IDRs are especially prevalent in eukaryotes suggesting the necessity of disorder, associated signaling and regulation in nucleated cells where they are involved in many key functions. However, also a correlation between intrinsic disorder and various human diseases such as cancer, diabetes, amyloidoses and neurodegenerative diseases is now evident, highlighting the great importance of the topic.

In this Special Issue, we invite researchers to contribute with original research articles as well as reviews, on the amazing world of the IDPs or IDRs involved with human diseases. In particular, contributions focusing on the prediction, identification and characterization of these, with emphasis to their role in cell-signaling and regulation will be welcomed.

Dr. Simona Maria Monti
Dr. Giuseppina De Simone
Dr. Emma Langella
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • intrinsically disordered proteins
  • intrinsically disordered regions
  • protein misfolding
  • functions of intrinsic disorder
  • molecular recognition features
  • protein-protein interactions
  • protein-nucleic acids interactions
  • protein disorder and pathology

Published Papers

This special issue is now open for submission.
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