RCE-4, a steroidal saponin isolated from Reineckia carnea, has been studied previously and has exhibited promising anti-cervical cancer properties by inducing programmed cell death (PCD) of Ca Ski cells. Considering the cancer cells developed various...
At the central region of the mammalian major histocompatibility complex (MHC) is a complement gene cluster that codes for constituents of complement C3 convertases (C2, factor B and C4). Complement activation drives the humoral effector functions for...
In recent years, an increasing number of projects have been developed in complex mountainous areas. The wind environment in mountainous areas, extremely complex due to the undulating terrain and diverse landscapes, is a key factor threatening the str...
Directional stability is an important performance criterion for alpine skis and has been shown to correlate with the second moment of running surface pressure distribution. However, this stability index is complex to measure while skiing and is not p...
Mature civil engineering software and platforms can provide a dynamic correlated situation of the road design, generate a quick and accurate grading design in terrain model making, and, most importantly, improve the design efficiency and calculation...
Background/Objectives: The aim of this study was to investigate patient-reported outcomes of patient expectations and fulfillment of expectations in alpine skiers who had a skiing accident and suffered a complex proximal tibial fracture (AO/OTA&mdash...
Alpine skiing is a complex sport that demands a high level of motor control and balance. In general, skiers are prone to deterioration in the state of fatigue due to using inappropriate equipment. As a consequence, the risk of injury might increase....
16 March 2021
There are numerous programs worldwide adapted for alpine ski beginners and they all share the same primary goal—inclusion of skiing beginners in alpine ski schools. The final elements of ski school taught in the parallel skiing technique are parallel...
At present, the mainstream laser point cloud classification algorithms are mainly based on the geometric information of the target. Nevertheless, if there is occlusion between the targets, the classification effect will be negatively affected. Compar...
Drugs targeting epigenetic mechanisms such as histone deacetylase inhibitors (HDACi) suppress tumor growth. HDACi also induce the expression of ligands for the cytotoxicity receptor NKG2D rendering tumors more susceptible to natural killer (NK) cell-...
As a critical component of ice-snow tourism, land cover classification for ski resorts is crucial to ice-snow resource management. However, there is currently a scarcity of datasets and methods capable of high-precision mapping for such fine-grained...
To investigate the characteristic pressure distribution patterns when gripping ski poles during skiing, this study addresses the challenges of measuring grip force on the complex curved surfaces of ski poles. A dataset of experimental samples was est...
The environment of ski resorts is usually complex and changeable, and there are few characteristic objects in the background, which creates many difficulties for the registration of ski-resort point cloud datasets. However, in the traditional iterati...
The aggressive features of glioblastoma (GBM) are associated with dormancy. Our previous transcriptome analysis revealed that several genes were regulated during temozolomide (TMZ)-promoted dormancy in GBM. Focusing on genes involved in cancer progre...
Snow avalanches are complex geomorphological processes that represent major natural hazards in mountain environments and result from the interaction between topographic, climatic, and human factors. This study represents the first attempt in Romania...
Arenaviruses include lethal human pathogens which pose serious public health threats. So far, no FDA approved vaccines are available against arenavirus infections, and therapeutic options are limited, making the identification of novel drug targets f...
Russia has considerable experience in the development of winter sports and ski resorts. The region around Lake Baikal possesses unique landscapes and cultural unity, making it a hot spot for winter tourism in Russia. The ski resorts around Lake Baika...
1 October 1999
Complex regional pain syndrome is a chronic pain syndrome that is often instigated by postoperative or post-traumatic events. The disease process can progress through three stages, the first of which tends to respond best to treatment. A review of th...
Purpose: To examine how coaches differentiate athletes with successful and non-successful development during a cross-country (XC) skiing talent transfer (TT) program. Methods: We conducted qualitative, semi-structured interviews with seven Norwegian...
In order to maintain a ski resort efficiently, regular inspections of the cableways are essential. However, there are some difficulties in discovering and observing the cable car cableways in the ski resort. This paper proposes a high-precision segme...
A secreted protein toxin encoded by a satellite dsRNA-enabled dissection of the genetic control of replication and expression of a single-segment dsRNA virus, the first Totivirus, L-A. Among the then-novel findings were i. “head-full replicatio...
The mountainous region of Greater Sochi, including the Olympic ski-jump complex area, located in the northern Caucasus, is always subjected to landslides. The weathered mudstone of low strength and potential high-intensity earthquakes are considered...
The high incidence of epithelial malignancies in HIV-1 infected individuals is associated with co-infection with oncogenic viruses, such as high-risk human papillomaviruses (HR HPVs), mostly HPV16. The molecular mechanisms underlying the HIV-1-associ...
The study investigated the systemic responses concerning oxy-inflammation, hormones, and mood after a ski mountaineering competition. Nine experienced military ski mountaineers (age, 32.37 ± 8.90 years; body mass, 59.37 ± 9.58 kg; BMI,...
3 February 2022
The complexity of skiing movements urges recreational alpine skiers and competitors to undertake many specific skill trainings not only during the season but also during the off-season using alternative sports. In AS, the role of the outside leg is c...
Objective: The stability of the flight phase in ski jumping is crucial for athletes’ performance and safety. This study aims to investigate the influence of unfavorable conditions on aerodynamic characteristics and flight stability through comp...
The ski-jump spillway is an energy-dissipating structure that discharges extra water beyond the dam’s capacity. The scour process occurs below spillways due to the collision of the water jet with high energy. It is critical to acquire informati...
The present study discusses foods for professional athletes since sports nutrition is the foundation of effective performance. A dietary supplement complex designed for ski orienteers, swimmers, road cyclists, and biathletes is described. The composi...
The performance of a light guide under arbitrary meteorological conditions is difficult to predict numerically because none of the present methods can account for the random configuration of clouds. Although, partly cloudy skies typically occur very...
The operation of a Remotely Piloted Aircraft System (RPAS) over a hilly area in northern Germany allows inspection of the variability of the profiles of temperature, humidity, and wind speed next to a small hill. Four cases in nearly stationary condi...
Fabry disease (FD) is an X-linked lysosomal disease due to a deficiency in the activity of the lysosomal-galactosidase A (GalA), a key enzyme in the glycosphingolipid degradation pathway. FD is a complex disease with a poor genotype–phenotype c...
This study examined the relationships between motivational processes and mental toughness in college skiers based on the self-determination theory (SDT). A total of 332 participants from four skiing items completed four psychological scales assessing...
Integrating solar power into electricity grids requires accurate short-term forecasting of the global horizontal irradiance to accurately predict the expected solar power generation. This paper compares five tree-based machine learning models against...
Cloud classification is a great challenge in meteorological research. The different types of clouds, currently known and present in our skies, can produce radioactive effects that impact the variation of atmospheric conditions, with consequent strong...
Background: Action observation (AO) and motor imagery (MI) are widely used cognitive training strategies. Recent evidence suggests that their combination may enhance motor simulation through synergistic neural mechanisms. However, the effects of this...
Background: Cervical cancer is among the highest-ranking types of cancer worldwide, with human papillomavirus (HPV) as the agent driving the malignant process. One aspect of the infection’s evolution is given by epigenetic modifications, mainly...
29 August 2022
Externally focused attention is known to induce superior results in the movement outcome, whereas focusing attention on the moving body (internal focus) causes conscious control and constrains action. The study investigated effects on knee trajectory...
The E6 and E7 oncoproteins of high-risk types of human papillomavirus (HR-HPV) are crucial for the development of cervical cancer (CC). Small interfering RNAs (siRNAs) are explored as novel therapies that silence these oncogenes, but their clinical u...
The difference between the functioning of the human non-visual and photopic systems has elicited the need for complex in situ measurements or time-consuming multi-spectral simulations to accurately predict the non-visual luminous content of the indoo...
The white shark (Carcharodon carcharias) is a charismatic species and, consequently, one of the most studied and protected sharks. This species can be found in a wide range of temperatures and depths, showing site fidelity and migrating across the oc...
The development of complex products with high quality in dynamic markets requires appropriate robust design and tolerancing workflows supporting the entire product development process. Despite the large number of methods and tools available for desig...
Despite a growing interest in player-centred methods for serious games, little is known on how to achieve this goal in practice when prospective users are children. Foundational questions remain unanswered, such as to which design dimensions children...
Golija Mountain, located in the southwestern part of Serbia, has been under protection as the Golija Nature Park since 2001. It is protected to preserve its forest ecosystems, diverse landscapes of exceptional beauty, and cultural heritage. Due to it...
The mobility of nitrogen (N) in the environment is conditioned by its cycling between atmospheric, terrestrial, and marine ecosystems. It is a key element for global biogeochemistry, and although isotope analysis has been an integral part of many stu...
Background/Objectives: Lower extremity injuries represent a major health concern in elite snowsport disciplines, where high mechanical loads, complex movement patterns, and demanding environmental conditions substantially increase injury risk. Unders...
Weather forecasting has always been challenging due to the atmosphere’s complex and dynamic nature. Weather conditions such as rain, clouds, clear skies, and sunniness are influenced by several factors, including temperature, pressure, humidity...
A series of 12 polysubstituted pyrrolo[3,4-b]pyridin-5-ones were synthesized via a one-pot cascade process (Ugi–3CR/aza Diels-Alder/N-acylation/decarboxylation/dehydration) and studied in vitro using human epithelial cervical carcinoma SiHa, He...
Default aerosol extinction coefficient profiles are commonly used instead of measured profiles in radiative transfer modeling, increasing the uncertainties in the simulations. The present study aimed to determine the magnitude of these uncertainties...
We used the spatially distributed and physically based snow cover model SNOWGRID-CL to derive daily grids of natural snow conditions and snowmaking potential at a spatial resolution of 1 × 1 km for Austria for the period 1961–2020 validat...
Solar Ultraviolet Radiation (UVR), which is identified as a major environmental health hazard, is responsible for a variety of photochemical reactions with direct effects on urban and aquatic ecosystems, human health, plant growth, and the deteriorat...
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