Myocarditis is an inflammatory disease of the myocardium that causes cardiogenic shock and death. However, endomyocardial biopsy that is, the gold standard for a diagnosis is limited. Apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1...
Inflammatory bowel disease (IBD) is characterized by chronic relapsing inflammation of the gastrointestinal tract. The prevalence of IBD is increasing with approximately 4.9 million cases reported worldwide. Current therapies are limited due to the s...
Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is involved in DNA base repair and reducing activity. However, the role of APE1/Ref-1 in atherosclerosis is unclear. Herein, we investigated the role of APE1/Ref-1 in atherosclerotic ap...
22 October 2024
Natural rubber production currently relies heavily on a single species, Hevea brasiliensis, underscoring the urgent need to identify alternative sources to alleviate the strain on natural rubber production. The rubber elongation factor (REF) and smal...
Acetylation of nuclear apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) is associated with its extracellular secretion, despite the lack of an N-terminal protein secretion signal. In this study, we investigated plasma membrane targeti...
Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein involved in DNA repair and redox regulation. The redox activity of APE1/Ref-1 is involved in inflammatory responses and regulation of DNA binding of transcr...
Human malignant melanoma exhibits imbalances in redox status, leading to activation of many redox-sensitive signaling pathways. APE/Ref-1 is a multifunctional protein that serves as a redox chaperone that regulates many nuclear transcription factors...
Vascular calcification plays a role in the pathogenesis of atherosclerosis, diabetes, and chronic kidney disease; however, the role of apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) in inorganic phosphate (Pi)-induced vascular smoot...
The simultaneous regulation of cancer cells and inflammatory immune cells in the tumor microenvironment (TME) can be an effective strategy in treating aggressive breast cancer types, such as triple-negative breast cancer (TNBC). Apurinic/apyrimidinic...
Seed germination is the first step in initiating a new life cycle in seed plants. Light is a major environmental factor affecting seed germination. Phytochrome B (phyB) is the primary photoreceptor promoting germination during the initial phase of im...
APE1/Ref-1 (apurinic/apyrimidinic endonuclease 1, APE1 or APEX1; redox factor-1, Ref-1) is a dual-functional enzyme with crucial roles in DNA repair, reduction/oxidation (redox) signaling, and RNA processing and metabolism. The redox function of Ref-...
Among many indoor positioning technologies, pseudolite positioning technology has become an important supplement to GNSS. In indoor open environments, pseudolite positioning technology can usually perform high-precision positioning. However, in a com...
Taraxacum kok-saghyz (TKS) is a model plant and a potential rubber-producing crop for the study of natural rubber (NR) biosynthesis. The precise analysis of the NR biosynthesis mechanism is an important theoretical basis for improving rubber yield. T...
Languages vary in expressing reflexivity and reciprocity. In some languages, reflexive and reciprocal constructions are formally identical, while in some other languages, they are distinct. The third group comprises languages that have non-reflexive...
Background: Triple-negative breast cancer (TNBC) is a highly aggressive subtype with limited therapeutic options due to the lack of estrogen, progesterone, and HER2 receptors. This study investigated the synergistic anticancer effects of recombinant...
This study addresses challenges such as multi-scale defects, varying lighting, and irregular shapes by proposing an improved YOLOv10 model that integrates the ECA attention mechanism, RefConv feature enhancement module, and WIoU loss function for com...
Sequence determination of complete or coding-complete genomes of viruses is becoming common practice for supporting the work of epidemiologists, ecologists, virologists, and taxonomists. Sequencing duration and costs are rapidly decreasing, sequencin...
Therapies with the mechanistic target of rapamycin complex 1 (mTORC1) inhibitors are not fully curative for tuberous sclerosis complex (TSC) patients. Here, we propose that some mTORC1-independent disease facets of TSC involve signaling through redox...
Endothelial dysfunction promotes vascular inflammation by inducing the production of reactive oxygen species and adhesion molecules. Vascular inflammation plays a key role in the pathogenesis of vascular diseases and atherosclerotic disorders. Howeve...
Camouflaged object detection (COD) remains a challenging task because objects blend into the background, exhibiting low contrast, incomplete edges, and highly similar appearances. Recent deep learning methods have improved detection performance, but...
Eccentric photorefractometry is widely used to measure eye refraction, accommodation, gaze position, and pupil size. While the individual calibration of refraction and accommodation data has been extensively studied, gaze measurements have received l...
To address the challenge posed by the abundance of small objects with weak object features and little information in the images of underwater biomonitoring scenarios, and the added difficulty of recognizing these objects due to light absorption and s...
This paper proposes a vibration reduction method for fractional slot concentrated winding (FSCW) permanent magnet synchronous motors (PMSMs) by applying a four-layer winding configuration. The radial electromagnetic force (REF), particularly its low...
Syringic acid, a phenolic compound, serves a variety of beneficial functions in cells. Syringic acid increases in plants in response to cesium, and exogenous application of syringic acid resulted in a significant attenuation of cesium-induced growth...
24 November 2021
The current study aimed to examine the relationship between metacognitive beliefs about suicidal ideation and the content and process of suicidal ideation. This was to examine the potential contribution of the Self-Regulatory Executive Function (S-RE...
The rubber elongation factor (REF) is the most abundant protein in the latex of Hevea brasiliensis, which is closely related to natural rubber biosynthesis. In order to gain a deeper understanding of the transcriptional regulation mechanism of HbREF1...
The UK open access (OA) policy landscape simultaneously preferences Gold publishing models (Finch Report, RCUK, COAF) and Green OA through repository usage (HEFCE), creating the possibility of confusion and duplication of effort for academics and sup...
Proliferative diabetic retinopathy (PDR), neovascular age-related macular degeneration (nvAMD), retinopathy of prematurity (ROP) and other eye diseases are characterized by retinal and/or choroidal neovascularization, ultimately causing vision loss i...
In photographs of evidence in forensic investigations, physical size references (e.g., rulers or stickers) are often placed next to a trace to allow us to take measurements from photos. However, this is laborious and introduces contamination risks. T...
There is growing evidence that apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) regulates inflammatory responses. Rheumatoid arthritis (RA) is an autoimmune disease, which is characterized with synovitis and joint destruction. Therefo...
Clinical outcomes in patients with reduced left ventricular systolic function undergoing rotational atherectomy (RA) for percutaneous coronary intervention (PCI) remain understudied. Our study sought to evaluate the impact of RA-PCI in patients with...
Lamiophlomis rotata (Benth.) Kudo is a perennial and unique medicinal plant of the Qinghai–Tibet Plateau. It has the effects of diminishing inflammation, activating blood circulation, removing blood stasis, reducing swelling, and relieving pain...
Apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) is a multifunctional protein that can be secreted, and recently suggested as new biomarker for vascular inflammation. However, the endogenous hormones for APE1/Ref-1 secretion and its u...
Epicauta gorhami is a hypermetamorphic insect that mainly forage soybeans during the adult stage. However, the lack of appropriate references hinders our studying of the gene function in E. gorhami. In this study, referring to five computational tool...
This study evaluates the effect of climate change on reference evapotranspiration (ET0), which is one of the most important variables in water resources management and irrigation scheduling. For this purpose, daily weather data of 30 Iranian weather...
Although several ant species are important targets for the development of molecular control strategies, only a few studies focus on identifying and validating reference genes for quantitative reverse transcription polymerase chain reaction (RT-qPCR)...
Papaver somniferum L. is an important medical plant that produces analgesic drugs used for the pain caused by cancers and surgeries. Recent studies have focused on the expression genes involved in analgesic drugs biosynthesis, and the real-time quant...
Eichhornia crassipes is a notorious invasive aquatic weed, causing enormous ecological and economic losses worldwide. However, it has great potential in agriculture, industry, medical care, and other areas. While being such an important plant, it is...
Effective response to flood events requires high-resolution, frequently updated data on flooded areas for comprehensive flood risk assessments. Unmanned aerial vehicles (UAVs) equipped with conventional camera systems and classification based on orth...
The soil insect Bradysia odoriphaga (Diptera: Sciaridae) causes substantial damage to Chinese chive. Suitable reference genes in B. odoriphaga (Bradysia odoriphaga) have yet to be identified for normalizing target gene expression among samples by qua...
Monitoring antibiotic resistance genes (ARGs) across ecological niches is critical for assessing the impacts distinct microbial communities have on the global spread of resistance. In permafrost-associated soils, climate and human driven disturbances...
This paper gives formal foundations and evidence from gene science in the post Barbara McClintock era that the Gödel Sentence, far from being an esoteric construction in mathematical logic, is ubiquitous in genomic intelligence that evolved with mult...
Diaphorencyrtus aligarhensis parasitizes the Asian citrus psyllid (ACP), Diaphorina citri, the primary insect vector responsible for transmitting Huanglongbing (HLB), a severe citrus disease. Screening of appropriate reference genes is a critical pre...
Hyblaea puera is a major pest of teak and mangroves. Reliable RT-qPCR normalization requires stable reference genes, none of which have been validated in H. puera. In this study, we assessed the expression stability of ten candidate reference genes u...
Lettuce is a popular vegetable source of bioactive compounds, like anthocyanins, powerful antioxidants present in red and semi-red varieties. Selection of reliable reference genes (RGs) for the normalization of real-time quantitative PCR (qPCR) data...
This paper details the development of an embedded system for vehicle data acquisition using the On-Board Diagnostics version 2 (OBD2) protocol, with the objective of predicting power loss caused by exhaust gas backpressure (EBP). The system decodes a...
Proximal sensing is fundamental to monitor the spatial and seasonal dynamics of ecosystems and can be considered as a crucial validation tool to upscale in situ observations to the satellite level. Linking hyperspectral remote sensing with carbon flu...
Background and Objectives: Propofol-based total intravenous anesthesia (TIVA) is presumed to have more favorable effects on the prognosis of patients with cancer compared with volatile inhaled anesthesia (VIA). We hypothesized that these anesthetics...
Background/Objectives: This study examined the impact of data pre-processing on indirectly derived reference intervals for intact parathyroid hormone (iPTH). Routine laboratory data from a single Norwegian site, measured on the Abbott Alinity i analy...
Bumble bees are important alternative pollinators and model insects due to their highly developed sociality and colony management. In order to better understand their molecular mechanisms, studies focusing on the genetic and molecular aspects of thei...
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