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  • Article
  • Open Access
5 Citations
3,658 Views
20 Pages

Orchid Mycorrhizal Association of Cultivated Dendrobium Hybrid and Their Role in Seed Germination and Seedling Growth

  • R. M. S. Ruwan Chamara,
  • Kazumitsu Miyoshi,
  • Tomohisa Yukawa,
  • Nobuyuki Asai and
  • Yuki Ogura-Tsujita

Orchids are crucial for the horticulture industry. Mycorrhizal fungi benefit crops by improving nutrition, plant growth, and disease resistance. However, the mycorrhizal association of horticultural hybrid orchids is poorly understood. To address thi...

(This article belongs to the Section Plant Microbe Interactions)
  • Article
  • Open Access
7 Citations
2,415 Views
19 Pages

Islanding Detection with Reduced Non-Detection Zones and Restoration by Reconfiguration

  • Sowmya Ramachandradurai,
  • Narayanan Krishnan,
  • Gulshan Sharma and
  • Pitshou N. Bokoro

27 March 2023

The development and use of PV (Photovoltaic), Wind, and Hydro-based Distributed Generation (DG) is presently on the rise worldwide for improving stability and reliability, and reducing the power loss in the distribution system with reduced emission o...

(This article belongs to the Section A1: Smart Grids and Microgrids)
  • Article
  • Open Access
23 Citations
6,845 Views
20 Pages

Automatic Extraction of Gravity Waves from All-Sky Airglow Image Based on Machine Learning

  • Chang Lai,
  • Jiyao Xu,
  • Jia Yue,
  • Wei Yuan and ,
  • Xiao Liu,
  • Wei Li and
  • Qinzeng Li
  • + 2 authors+ 0 author

27 June 2019

With the development of ground-based all-sky airglow imager (ASAI) technology, a large amount of airglow image data needs to be processed for studying atmospheric gravity waves. We developed a program to automatically extract gravity wave patterns in...

(This article belongs to the Special Issue Convolutional Neural Networks Applications in Remote Sensing)
  • Article
  • Open Access
8 Citations
3,229 Views
12 Pages

9 November 2021

Atmospheric pressure chemical ionization (APCI)-mass spectrometry (MS) and electrospray ionization (ESI)-MS can cover the analysis of analytes from low to high polarities. Thus, an ion source that possesses these two ionization functions is useful. A...

(This article belongs to the Special Issue Mass Spectrometry Analysis)
  • Article
  • Open Access
3 Citations
9,289 Views
11 Pages

Influence of Comprehensive Pre-Anaesthetic Assessment on ASA Classification and Surgical Cancellations in Dogs and Cats: A Retrospective Observational Study

  • Ariel Cañón Pérez,
  • María De Los Reyes Marti-Scharfhausen Sánchez,
  • Antonio Sevilla Ureba,
  • Eva Zoe Hernández Magaña and ,
  • Jaime Viscasillas Monteagudo,
  • Agustín Martínez Albiñana and
  • José I. Redondo
  • + 2 authors+ 0 author

23 June 2025

Anaesthesia carries an inherent risk of morbidity and mortality in veterinary patients, yet the clinical impact of comprehensive pre-anaesthetic assessment (PAA) is insufficiently quantified. We retrospectively reviewed 350 PAAs including 267 dogs an...

  • Article
  • Open Access
10 Citations
6,276 Views
12 Pages

Briarane Diterpenoids from the Gorgonian Dichotella gemmacea

  • Ming-Ping La,
  • Jiao Li,
  • Cui Li,
  • Hua Tang and ,
  • Bao-Shu Liu,
  • Peng Sun,
  • Chun-Lin Zhuang,
  • Tie-Jun Li and
  • Wen Zhang
  • + 4 authors+ 0 author

18 December 2014

Seven new briarane diterpenoids, gemmacolides AS-AY (1–7), were isolated together with ten known analogues (8–17) from the South China Sea gorgonian Dichotella gemmacea. The structures of the new compounds were elucidated by the detailed analysis of...

  • Article
  • Open Access
2,623 Views
27 Pages

7 October 2025

Atmospheric gravity waves (AGWs) are treated as density structure perturbations of the atmosphere and play an important role in atmospheric dynamics. Utilizing All-Sky Airglow Imagers (ASAIs) with OI-Filter 557.7 nm, AGW phase velocity and propagatio...

  • Article
  • Open Access
9 Citations
4,482 Views
19 Pages

The genera Komagataeibacter and Novacetimonas comprise industrially important species that produce various foods, nanocellulose, acetan-like polysaccharides, enantioselective sugars, and other valuable products. Here, we describe two novel strains, H...

(This article belongs to the Section Microbial Biotechnology)
  • Review
  • Open Access
11 Citations
5,772 Views
21 Pages

Immuno-Surgical Management of Pancreatic Cancer with Analysis of Cancer Exosomes

  • Yu Takeda,
  • Shogo Kobayashi,
  • Masatoshi Kitakaze,
  • Daisaku Yamada and ,
  • Hirofumi Akita,
  • Ayumu Asai,
  • Masamitsu Konno,
  • Takahiro Arai,
  • Toru Kitagawa and
  • Hideshi Ishii
  • + 12 authors+ 7 authors

9 July 2020

Exosomes (EXs), a type of extracellular vesicles secreted from various cells and especially cancer cells, mesenchymal cells, macrophages and other cells in the tumor microenvironment (TME), are involved in biologically malignant behaviors of cancers....

(This article belongs to the Collection Targeting Signal Transduction Pathways and Non-coding RNAs as Potential Therapy in Cancer and Aging)
  • Article
  • Open Access
153 Citations
15,551 Views
9 Pages

9 July 2020

Obesity is characterized by massive adipose tissue accumulation and is associated with psychiatric disorders and cognitive impairment in human and animal models. However, it is unclear whether high-fat diet (HFD)-induced obesity presents a risk of ps...

(This article belongs to the Section Nutrition and Metabolism)
  • Review
  • Open Access
54 Citations
15,812 Views
9 Pages

COVID-19 Drug Discovery Using Intensive Approaches

  • Ayumu Asai,
  • Masamitsu Konno,
  • Miyuki Ozaki,
  • Chihiro Otsuka and ,
  • Andrea Vecchione,
  • Takahiro Arai,
  • Toru Kitagawa,
  • Ken Ofusa,
  • Masami Yabumoto and
  • Hideshi Ishii
  • + 9 authors+ 4 authors

Since the infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported in China during December 2019, the coronavirus disease 2019 (COVID-19) has spread on a global scale, causing the World Health Organizatio...

(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
  • Article
  • Open Access
6 Citations
6,486 Views
19 Pages

Quantification of the Ability of Natural Products to Prevent Herpes Virus Infection

  • Kunihiko Fukuchi,
  • Hiroshi Sakagami,
  • Yoshiaki Sugita,
  • Koichi Takao and ,
  • Daisuke Asai,
  • Shigemi Terakubo,
  • Hiromu Takemura,
  • Hirokazu Ohno,
  • Misaki Horiuchi and
  • Takaaki Oizumi
  • + 10 authors+ 5 authors

6 October 2020

Background: Herpes simplex virus (HSV) is usually dormant and becomes apparent when body conditions decline. We investigated the anti-HSV activity of various natural and synthetic compounds for future clinical application. Methods: Mock- and HSV-infe...

(This article belongs to the Special Issue Research Topics in Medicines and How Our Board Members Are Engaged in Them)
  • Article
  • Open Access
18 Citations
11,738 Views
35 Pages

Attention Networks in ADHD Adults after Working Memory Training with a Dual n-Back Task

  • Masashi Dotare,
  • Michel Bader,
  • Sarah K. Mesrobian,
  • Yoshiyuki Asai and ,
  • Alessandro E. P. Villa and
  • Alessandra Lintas
  • + 1 author+ 0 author

8 October 2020

Patients affected by Attention-Deficit/Hyperactivity Disorder (ADHD) are characterized by impaired executive functioning and/or attention deficits. Our study aim is to determine whether the outcomes measured by the Attention Network Task (ANT), i.e.,...

(This article belongs to the Section Computational Neuroscience, Neuroinformatics, and Neurocomputing)
  • Article
  • Open Access
8 Citations
3,055 Views
14 Pages

Programmed Death 1 Ligand Expression in the Monocytes of Patients with Hepatocellular Carcinoma Depends on Tumor Progression

  • Akira Asai,
  • Hidetaka Yasuoka,
  • Masahiro Matsui,
  • Yusuke Tsuchimoto and ,
  • Shinya Fukunishi and
  • Kazuhide Higuchi
  • + 1 author+ 0 author

14 August 2020

Monocytes (CD14+ cells) from advanced-stage hepatocellular carcinoma (HCC) patients express programmed death 1 ligand (PD-L)/PD-1 and suppress the host antitumor immune response. However, it is unclear whether cancer progression is associated with CD...

(This article belongs to the Special Issue Immunotherapy in Hepatocellular Carcinoma)
  • Article
  • Open Access
27 Citations
3,937 Views
22 Pages

FAM64A: A Novel Oncogenic Target of Lung Adenocarcinoma Regulated by Both Strands of miR-99a (miR-99a-5p and miR-99a-3p)

  • Keiko Mizuno,
  • Kengo Tanigawa,
  • Nijiro Nohata,
  • Shunsuke Misono and ,
  • Reona Okada,
  • Shunichi Asai,
  • Shogo Moriya,
  • Takayuki Suetsugu,
  • Hiromasa Inoue and
  • Naohiko Seki
  • + 5 authors+ 0 author

11 September 2020

Lung adenocarcinoma (LUAD) is the most aggressive cancer and the prognosis of these patients is unfavorable. We revealed that the expression levels of both strands of miR-99a (miR-99a-5p and miR-99a-3p) were significantly suppressed in several cancer...

(This article belongs to the Special Issue microRNA as Therapeutic Target)
  • Article
  • Open Access
7 Citations
7,039 Views
8 Pages

25 August 2020

Soccer balls have undergone dramatic changes in their surface structure that can affect their aerodynamics. The properties of the soccer ball surface such as the panel shape, panel orientation, seam characteristics, and surface roughness have a signi...

(This article belongs to the Special Issue Sports Fluid Mechanics)
  • Article
  • Open Access
20 Citations
4,694 Views
7 Pages

Convolutional Neural Network Can Recognize Drug Resistance of Single Cancer Cells

  • Kiminori Yanagisawa,
  • Masayasu Toratani,
  • Ayumu Asai,
  • Masamitsu Konno and ,
  • Hirohiko Niioka,
  • Tsunekazu Mizushima,
  • Taroh Satoh,
  • Jun Miyake,
  • Kazuhiko Ogawa and
  • Hideshi Ishii
  • + 8 authors+ 3 authors

It is known that single or isolated tumor cells enter cancer patients’ circulatory systems. These circulating tumor cells (CTCs) are thought to be an effective tool for diagnosing cancer malignancy. However, handling CTC samples and evaluating...

(This article belongs to the Special Issue Metastasis Inhibition)
  • Article
  • Open Access
3 Citations
3,489 Views
15 Pages

Characteristic Evaluation of Chameleon Luminophore Dispersed in Polymer

  • Miku Kasai,
  • Yosuke Sugioka,
  • Masanori Yamamoto,
  • Takayuki Nagata and ,
  • Taku Nonomura,
  • Keisuke Asai and
  • Yasuchika Hasegawa
  • + 2 authors+ 0 author

4 May 2020

A temperature-sensitive paint (TSP) using a chameleon luminophore [ Tb 0.99 Eu 0.01 ( hfa ) 3 ( dpbp ) ] n is proposed. The chameleon luminophore was dispersed in isobutyl methacrylate polymer in a toluene solvent to fix it on...

(This article belongs to the Special Issue Fluorescent Sensors)
  • Article
  • Open Access
8 Citations
12,637 Views
7 Pages

Aerodynamic Characteristics of New Volleyball for the 2020 Tokyo Olympics

  • Sungchan Hong,
  • Hiroki Ozaki,
  • Keita Watanabe and
  • Takeshi Asai

7 May 2020

The pattern of a modern volleyball is greatly different from that of a conventional volleyball, with several changes being made to the shape and design of the surface on the ball. Furthermore, at the 2020 Tokyo Olympics, a new volleyball (V200W; Mika...

(This article belongs to the Section Materials Science and Engineering)
  • Article
  • Open Access
15 Citations
3,563 Views
15 Pages

Effect of Oxygen Mole Fraction on Static Properties of Pressure-Sensitive Paint

  • Tomohiro Okudera,
  • Takayuki Nagata,
  • Miku Kasai,
  • Yuji Saito and ,
  • Taku Nonomura and
  • Keisuke Asai
  • + 1 author+ 0 author

4 February 2021

The effects of the oxygen mole fraction on the static properties of pressure-sensitive paint (PSP) were investigated. Sample coupon tests using a calibration chamber were conducted for poly(hexafluoroisopropyl methacrylate)-based PSP (PHFIPM-PSP), po...

(This article belongs to the Special Issue Optical Sensors for Flow Diagnostics)
  • Article
  • Open Access
10 Citations
3,495 Views
13 Pages

CD4, CD8b, and Cytokines Expression Profiles in Peripheral Blood Mononuclear Cells Infected with Different Subtypes of KoRV from Koalas (Phascolarctos cinereus) in a Japanese Zoo

  • Mohammad Enamul Hoque Kayesh,
  • Md Abul Hashem,
  • Fumie Maetani,
  • Taiki Eiei and ,
  • Kyoya Mochizuki,
  • Shinsaku Ochiai,
  • Ayaka Ito,
  • Nanao Ito,
  • Hiroko Sakurai and
  • Kyoko Tsukiyama-Kohara
  • + 6 authors+ 1 author

9 December 2020

Koala retrovirus (KoRV) poses a major threat to koala health and conservation, and currently has 10 identified subtypes: an endogenous subtype (KoRV-A) and nine exogenous subtypes (KoRV-B to KoRV-J). However, subtype-related variations in koala immun...

(This article belongs to the Special Issue Animal and Wildlife Viruses)
  • Article
  • Open Access
19 Citations
3,492 Views
17 Pages

Regulation of Oncogenic Targets by the Tumor-Suppressive miR-139 Duplex (miR-139-5p and miR-139-3p) in Renal Cell Carcinoma

  • Reona Okada,
  • Yusuke Goto,
  • Yasutaka Yamada,
  • Mayuko Kato and ,
  • Shunichi Asai,
  • Shogo Moriya,
  • Tomohiko Ichikawa and
  • Naohiko Seki
  • + 3 authors+ 0 author

We previously found that both the guide and passenger strands of the miR-139 duplex (miR-139-5p and miR-139-3p, respectively) were downregulated in cancer tissues. Analysis of TCGA datasets revealed that low expression of miR-139-5p (p < 0.0001) a...

(This article belongs to the Special Issue MicroRNA in Solid Tumor and Hematological Diseases)
  • Article
  • Open Access
21 Citations
5,004 Views
12 Pages

TAK1 Mediates ROS Generation Triggered by the Specific Cephalosporins through Noncanonical Mechanisms

  • Midori Suzuki,
  • Yukino Asai,
  • Tomohiro Kagi,
  • Takuya Noguchi and ,
  • Mayuka Yamada,
  • Yusuke Hirata and
  • Atsushi Matsuzawa
  • + 2 authors+ 0 author

14 December 2020

It is known that a wide variety of antibacterial agents stimulate generation of reactive oxygen species (ROS) in mammalian cells. However, its mechanisms are largely unknown. In this study, we unexpectedly found that transforming growth factor-β...

(This article belongs to the Special Issue Kinase Signal Transduction 2.0)
  • Article
  • Open Access
6 Citations
8,423 Views
11 Pages

3 March 2021

In cycling, air resistance corresponds to 90% of the resistance on the bicycle and cyclist and 70% of this is applied to the body of the cyclist. Despite research on postures that could reduce air resistance, few studies have been conducted on full-b...

(This article belongs to the Special Issue Sports Fluid Mechanics)
  • Communication
  • Open Access
13 Citations
4,781 Views
10 Pages

Long- and Short-Term Conductance Control of Artificial Polymer Wire Synapses

  • Naruki Hagiwara,
  • Shoma Sekizaki,
  • Yuji Kuwahara,
  • Tetsuya Asai and
  • Megumi Akai-Kasaya

19 January 2021

Networks in the human brain are extremely complex and sophisticated. The abstract model of the human brain has been used in software development, specifically in artificial intelligence. Despite the remarkable outcomes achieved using artificial intel...

(This article belongs to the Special Issue Applications of Polymers in Energy and Environmental Sciences)
  • Article
  • Open Access
12 Citations
6,753 Views
13 Pages

Population Pharmacokinetics Analysis of Amikacin Initial Dosing Regimen in Elderly Patients

  • Hideo Kato,
  • Suzanne L. Parker,
  • Jason A. Roberts,
  • Mao Hagihara and ,
  • Nobuhiro Asai,
  • Yuka Yamagishi,
  • David L. Paterson and
  • Hiroshige Mikamo
  • + 3 authors+ 0 author

There are limited data of amikacin pharmacokinetics (PK) in the elderly population. Hence, we aimed to describe the population PK of amikacin in elderly patients (>70 years old) and to establish optimized initial dosing regimens. We simulated indi...

  • Article
  • Open Access
7 Citations
3,546 Views
16 Pages

Upregulation of Chemoresistance by Mg2+ Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells

  • Saki Onuma,
  • Aya Manabe,
  • Yuta Yoshino,
  • Toshiyuki Matsunaga and ,
  • Tomohiro Asai and
  • Akira Ikari
  • + 1 author+ 0 author

12 May 2021

Several anticancer drugs including cisplatin (CDDP) induce hypomagnesemia. However, it remains fully uncertain whether Mg2+ deficiency affects chemosensitivity of cancer cells. Here, we investigated the effect of low Mg2+ concentration (LM) on prolif...

(This article belongs to the Collection Oxidative Stress in Human Health and Disease)
  • Article
  • Open Access
11 Citations
6,469 Views
10 Pages

Relationship between Vitamin Intake and Health-Related Quality of Life in a Japanese Population: A Cross-Sectional Analysis of the Shika Study

  • Nobuhiko Narukawa,
  • Hiromasa Tsujiguchi,
  • Akinori Hara,
  • Sakae Miyagi and ,
  • Takayuki Kannon,
  • Keita Suzuki,
  • Yukari Shimizu,
  • Thao Thi Thu Nguyen,
  • Kim Oanh Pham and
  • Hiroyuki Nakamura
  • + 20 authors+ 15 authors

22 March 2021

Although epidemiological studies revealed a relationship between psychosocial states, such as depressive symptoms, and nutritional intake, limited information is currently available on vitamin intake. The Short Form-36 Health Survey (SF-36) is not li...

(This article belongs to the Section Micronutrients and Human Health)
  • Article
  • Open Access
14 Citations
4,434 Views
15 Pages

Root Response to Soil Water Status via Interaction of Crop Genotype and Environment

  • Phanthasin Khanthavong,
  • Shin Yabuta,
  • Hidetoshi Asai,
  • Md. Amzad Hossain and ,
  • Isao Akagi and
  • Jun-Ichi Sakagami
  • + 1 author+ 0 author

8 April 2021

Flooding and drought are major causes of reductions in crop productivity. Root distribution indicates crop adaptation to water stress. Therefore, we aimed to identify crop roots response based on root distribution under various soil conditions. The r...

(This article belongs to the Special Issue Adaptation of Crops to Climatically Variable Environments: Physiological and Agronomic Strategies)
  • Article
  • Open Access
6 Citations
7,668 Views
16 Pages

9 April 2021

This article is a review of ongoing research on analytical, numerical, and mixed methods for the solution of the third-order nonlinear Falkner–Skan boundary-value problem, which models the non-dimensional velocity distribution in the laminar boundary...

(This article belongs to the Special Issue Recent Advances in Computational Methods in Fluid Dynamics and Applications)
  • Article
  • Open Access
13 Citations
3,048 Views
20 Pages

Impact of Drying on Structural Performance of Reinforced Concrete Beam with Slab

  • Pranjal Satya,
  • Tatsuya Asai,
  • Masaomi Teshigawara,
  • Yo Hibino and
  • Ippei Maruyama

10 April 2021

Evaluating the performance of reinforced concrete (RC) structures during earthquakes and the resultant damage in the structures depends on an accurate load–displacement relationship. Several experimental and analytical evaluation methods for load–dis...

(This article belongs to the Section Construction and Building Materials)
  • Article
  • Open Access
5 Citations
4,151 Views
12 Pages

Jet Dynamics Associated with Drop Impact on Micropillared Substrate

  • Brooklyn Asai,
  • Anayet Ullah Siddique and
  • Hua Tan

12 April 2021

The jetting phenomenon associated with droplet impact upon a hydrophilic micropillared substrate was analyzed in detail using a high-speed camera. Viscosities of the fluids were varied using differing concentrations of glycerol in deionized water. Th...

(This article belongs to the Special Issue Dynamics of Droplets and Bubbles)
  • Article
  • Open Access
26 Citations
4,145 Views
12 Pages

Clinical Outcomes of Digital Cholangioscopy-Guided Procedures for the Diagnosis of Biliary Strictures and Treatment of Difficult Bile Duct Stones: A Single-Center Large Cohort Study

  • Hirohito Minami,
  • Shuntaro Mukai,
  • Atsushi Sofuni,
  • Takayoshi Tsuchiya and ,
  • Kentaro Ishii,
  • Reina Tanaka,
  • Ryosuke Tonozuka,
  • Mitsuyoshi Honjo,
  • Kenjiro Yamamoto and
  • Takao Itoi
  • + 11 authors+ 6 authors

12 April 2021

Although Spy DS (SpyGlass DS Direct Visualization System) is considered to be useful for the diagnosis of bile duct strictures and the treatment of bile duct stones, there is limited data to date validating its efficacy. We hence retrospectively eval...

(This article belongs to the Special Issue Clinical Advances of Endoscopy in Pancreaticobiliary Disease)
  • Article
  • Open Access
10 Citations
3,629 Views
12 Pages

Association between the blaCTX-M-14-harboring Escherichia coli Isolated from Weasels and Domestic Animals Reared on a University Campus

  • Montira Yossapol,
  • Miku Yamamoto,
  • Michiyo Sugiyama,
  • Justice Opare Odoi and ,
  • Tsutomu Omatsu,
  • Tetsuya Mizutani,
  • Kenji Ohya and
  • Tetsuo Asai
  • + 3 authors+ 0 author

Antimicrobial-resistant (AMR) bacteria affect human and animal health worldwide. Here, CTX-M-14-producing Escherichia coli isolates were isolated from Siberian weasels (Mustela sibirica) that were captured on a veterinary campus. To clarify the sourc...

(This article belongs to the Special Issue Antimicrobial Resistance and the Environment: One Health Approach)
  • Article
  • Open Access
16 Citations
5,670 Views
16 Pages

Positive Effects of Oral Antibiotic Administration in Murine Chronic Graft-Versus-Host Disease

  • Shinri Sato,
  • Eisuke Shimizu,
  • Jingliang He,
  • Mamoru Ogawa and ,
  • Kazuki Asai,
  • Hiroyuki Yazu,
  • Robert Rusch,
  • Mio Yamane,
  • Fan Yang and
  • Yoko Ogawa
  • + 8 authors+ 3 authors

Chronic graft-versus-host disease (cGVHD) is one of the most frequent complications experienced after allogeneic hematopoietic stem cell transplantation. Reportedly, dysbiosis and severe damage to the microbiome are also closely associated with GVHD....

(This article belongs to the Special Issue Pathophysiological Mechanisms in Ocular Graft-versus-Host Disease)
  • Article
  • Open Access
31 Citations
4,526 Views
21 Pages

Molecular Pathogenesis and Regulation of the miR-29-3p-Family: Involvement of ITGA6 and ITGB1 in Intra-Hepatic Cholangiocarcinoma

  • Yuto Hozaka,
  • Naohiko Seki,
  • Takako Tanaka,
  • Shunichi Asai and ,
  • Shogo Moriya,
  • Tetsuya Idichi,
  • Masumi Wada,
  • Kiyonori Tanoue,
  • Yota Kawasaki and
  • Takao Ohtsuka
  • + 7 authors+ 2 authors

4 June 2021

The aggressive nature of intrahepatic cholangiocarcinoma (ICC) renders it a particularly lethal solid tumor. Searching for therapeutic targets for ICC is an essential challenge in the development of an effective treatment strategy. Our previous studi...

(This article belongs to the Special Issue Hepatobiliary and Pancreatic Neoplasms: Biomarkers and Targeted Therapy)
  • Article
  • Open Access
2,425 Views
10 Pages

Association between Administration of Antithrombotics and Intraperitoneal Hemorrhage in Patients Undergoing Percutaneous Interventions for Liver Diseases

  • Akira Asai,
  • Keisuke Yokohama,
  • Hideko Ohama,
  • Yusuke Tsuchimoto and ,
  • Shinya Fukunishi and
  • Kazuhide Higuchi
  • + 1 author+ 0 author

7 June 2021

Currently, percutaneous interventions are essential for diagnosis and treatment of liver diseases. The most frequent complication of percutaneous interventions is intraperitoneal hemorrhage. Recently, the number of patients with liver diseases on ant...

(This article belongs to the Collection Clinical Research in Hepatology)
  • Article
  • Open Access
25 Citations
4,902 Views
16 Pages

Identification of Tumor Suppressive Genes Regulated by miR-31-5p and miR-31-3p in Head and Neck Squamous Cell Carcinoma

  • Sachi Oshima,
  • Shunichi Asai,
  • Naohiko Seki,
  • Chikashi Minemura and ,
  • Takashi Kinoshita,
  • Yusuke Goto,
  • Naoko Kikkawa,
  • Shogo Moriya,
  • Atsushi Kasamatsu and
  • Katsuhiro Uzawa
  • + 6 authors+ 1 author

We identified the microRNA (miRNA) expression signature of head and neck squamous cell carcinoma (HNSCC) tissues by RNA sequencing, in which 168 miRNAs were significantly upregulated, including both strands of the miR-31 duplex (miR-31-5p and miR-31-...

(This article belongs to the Special Issue Advances in Molecular Mechanism of Head and Neck Cancer)
  • Article
  • Open Access
10 Citations
4,478 Views
12 Pages

Fabrication of Liquid Scintillators Loaded with 6-Phenylhexanoic Acid-Modified ZrO2 Nanoparticles for Observation of Neutrinoless Double Beta Decay

  • Akito Watanabe,
  • Arisa Magi,
  • Akira Yoko,
  • Gimyeong Seong and ,
  • Takaaki Tomai,
  • Tadafumi Adschiri,
  • Yamato Hayashi,
  • Masanori Koshimizu,
  • Yutaka Fujimoto and
  • Keisuke Asai
  • + 5 authors+ 0 author

27 April 2021

The observation of neutrinoless double beta decay is an important issue in nuclear and particle physics. The development of organic liquid scintillators with high transparency and a high concentration of the target isotope would be very useful for ne...

(This article belongs to the Special Issue Hydrothermal Synthesis of Nanoparticles)
  • Review
  • Open Access
45 Citations
6,173 Views
13 Pages

Sarcopenia and Frailty in Liver Cirrhosis

  • Hiroki Nishikawa,
  • Shinya Fukunishi,
  • Akira Asai,
  • Shuhei Nishiguchi and
  • Kazuhide Higuchi

27 April 2021

Skeletal muscle is the largest organ in the body, and skeletal muscle atrophy results from a shift in the balance of protein synthesis and degradation toward protein breakdown. Primary sarcopenia is defined as a loss of skeletal muscle mass and stren...

(This article belongs to the Special Issue Sarcopenia and Liver Disease: Current and Future Perspectives)
  • Article
  • Open Access
36 Citations
5,618 Views
20 Pages

Frequency Response of Pressure-Sensitive Paints under Low-Pressure Conditions

  • Miku Kasai,
  • Daisuke Sasaki,
  • Takayuki Nagata,
  • Taku Nonomura and
  • Keisuke Asai

4 May 2021

The characteristics of fast-response pressure-sensitive paints (PSPs) in low-pressure conditions were evaluated. Three representative porous binders were investigated: polymer-ceramic PSP (PC-PSP), anodized-aluminum PSP (AA-PSP), and thin-layer chrom...

(This article belongs to the Special Issue Optical Sensors for Flow Diagnostics)
  • Article
  • Open Access
2 Citations
4,436 Views
21 Pages

Asymptotic and Finite Sample Properties for Multivariate Rotated GARCH Models

  • Manabu Asai,
  • Chia-Lin Chang,
  • Michael McAleer and
  • Laurent Pauwels

This paper derives the statistical properties of a two-step approach to estimating multivariate rotated GARCH-BEKK (RBEKK) models. From the definition of RBEKK, the unconditional covariance matrix is estimated in the first step to rotate the observed...

  • Article
  • Open Access
3 Citations
5,062 Views
13 Pages

Re-Evaluation of Chemotherapeutic Potential of Pyoktanin Blue

  • Hiroshi Sakagami,
  • Toshiko Furukawa,
  • Keitaro Satoh,
  • Shigeru Amano and ,
  • Yosuke Iijima,
  • Takuro Koshikawa,
  • Daisuke Asai,
  • Kunihiko Fukuchi,
  • Hiromu Takemura and
  • Satoshi Yokose
  • + 6 authors+ 1 author

Background: Pyoktanin blue (PB) is used for staining tissues and cells, and it is applied in photodynamic therapy due to its potent bactericidal activity. However, clinical application of PB as an antiviral and antitumor agent has been limited due to...

(This article belongs to the Section Cancer Biology and Anticancer Therapeutics)
  • Feature Paper
  • Article
  • Open Access
9 Citations
8,637 Views
15 Pages

Flow Visualization of Spinning and Nonspinning Soccer Balls Using Computational Fluid Dynamics

  • Takeshi Asai,
  • Yasumi Nakanishi,
  • Nakaba Akiyama and
  • Sungchan Hong

30 June 2020

Various studies have been conducted on the aerodynamic characteristics of nonspinning and spinning soccer balls. However, the vortex structures in the wake of the balls are almost unknown. One of the main computational fluid dynamics methods used for...

(This article belongs to the Special Issue Sports Fluid Mechanics)
  • Article
  • Open Access
10 Citations
4,273 Views
17 Pages

Lignosulfonate Rapidly Inactivates Human Immunodeficiency and Herpes Simplex Viruses

  • Kunihiko Fukuchi,
  • Takuro Koshikawa,
  • Daisuke Asai,
  • Megumi Inomata and ,
  • Hiroshi Sakagami,
  • Hiromu Takemura,
  • Taisei Kanamoto,
  • Hikaru Aimi and
  • Yuji Kikkawa
  • + 4 authors+ 0 author

3 October 2021

Background: Very few studies of the antiviral potential of lignosulfonates have been published. With the aim of oral application, among various groups of natural products, the relative antiviral potency of lignosulfonate and its ability to rapidly in...

(This article belongs to the Section Oral Medicine and Dentistry)
  • Article
  • Open Access
1 Citations
3,939 Views
9 Pages

Lymphocyte-to-Monocyte Ratio as a Marker for Endoscopic Activity in Ulcerative Colitis

  • Natsuki Ishida,
  • Satoru Takahashi,
  • Yusuke Asai,
  • Takahiro Miyazu and ,
  • Satoshi Tamura,
  • Shinya Tani,
  • Mihoko Yamade,
  • Moriya Iwaizumi,
  • Yasushi Hamaya and
  • Ken Sugimoto
  • + 7 authors+ 2 authors

3 October 2021

Leukocyte subtypes can be used to evaluate the severity of ulcerative colitis (UC). In this study, we examined the relationship between the lymphocyte-to-monocyte ratio (LMR) and the Mayo endoscopic score (MES) in assessing endoscopic activity in UC....

(This article belongs to the Special Issue GI Tract Immunology and Mucosal Immunity)
  • Review
  • Open Access
306 Citations
21,885 Views
12 Pages

Metabolic Syndrome and Sarcopenia

  • Hiroki Nishikawa,
  • Akira Asai,
  • Shinya Fukunishi,
  • Shuhei Nishiguchi and
  • Kazuhide Higuchi

7 October 2021

Skeletal muscle is a major organ of insulin-induced glucose metabolism. In addition, loss of muscle mass is closely linked to insulin resistance (IR) and metabolic syndrome (Met-S). Skeletal muscle loss and accumulation of intramuscular fat are assoc...

(This article belongs to the Special Issue Biomarker of Stress, Metabolic Syndrome and Human Health)
  • Review
  • Open Access
175 Citations
13,932 Views
13 Pages

The Lung Microbiome during Health and Disease

  • Kazuma Yagi,
  • Gary B. Huffnagle,
  • Nicholas W. Lukacs and
  • Nobuhiro Asai

8 October 2021

Healthy human lungs have traditionally been considered to be a sterile organ. However, culture-independent molecular techniques have reported that large numbers of microbes coexist in the lung and airways. The lungs harbor diverse microbial compositi...

(This article belongs to the Special Issue Host-Microbe Interaction 3.0)
  • Article
  • Open Access
2 Citations
5,114 Views
29 Pages

Towards the Inhibition of Protein–Protein Interactions (PPIs) in STAT3: Insights into a New Class of Benzothiadiazole Derivatives

  • Matteo Mori,
  • Ettore Gilardoni,
  • Luca Regazzoni,
  • Alessandro Pedretti and ,
  • Diego Colombo,
  • Gary Parkinson,
  • Akira Asai,
  • Fiorella Meneghetti,
  • Stefania Villa and
  • Arianna Gelain
  • + 5 authors+ 0 author

31 July 2020

Signal transducer and activator of transcription 3 (STAT3) is a validated anticancer target due to the relationship between its constitutive activation and malignant tumors. Through a virtual screening approach on the STAT3-SH2 domain, 5,6-dimethyl-1...

(This article belongs to the Section Medicinal Chemistry)
  • Article
  • Open Access
13 Citations
4,723 Views
11 Pages

In Vivo Pharmacodynamics of β-Lactams/Nacubactam against Carbapenem-Resistant and/or Carbapenemase-Producing Enterobacter cloacae and Klebsiella pneumoniae in Murine Pneumonia Model

  • Mao Hagihara,
  • Hideo Kato,
  • Toshie Sugano,
  • Hayato Okade and ,
  • Nobuo Sato,
  • Yuichi Shibata,
  • Daisuke Sakanashi,
  • Jun Hirai,
  • Nobuhiro Asai and
  • Hiroshige Mikamo
  • + 7 authors+ 2 authors

28 September 2021

Carbapenem-resistant Enterobacterales (CRE) and carbapenemase-producing Enterobacterales (CPE) have become global threats. CRE− and CPE− derived infections have been associated with high mortality due to limited treatment options. Nacubactam is a β-l...

(This article belongs to the Special Issue Combination Therapy against Multidrug-Resistant Pathogens)

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