Targeting Signal Transduction Pathways and Non-coding RNAs as Potential Therapy in Cancer and Aging

Dear Colleagues,

World Health Organization estimates indicate that death from cancer will be the leading cause of death in the world in the next decade, with approximately 22 million new cases per year. It is known that the risk of cancer increases with an individual’s age. If we consider that in the coming decades, the number of people over 65 will double, it is clear that the prevalence of oncological disease will increase in parallel with the aging of the global population.

Cancer is a complex disease in which mutations in the DNA cause the activation of aberrant cellular signals that ultimately affect numerous cellular functions, such as those impacting cell survival, proliferation, and metabolism, as well as communication between different cell types in the cancer microenvironment. Together, these distinctive traits allow tumors to develop, grow, metastasize, and resist therapies.

Aging is also a complex process in which DNA damage and alterations of numerous cellular signals lead to the development of aging-related diseases.

For this Topical Collection, we would like to invite original research articles as well as review articles that address the application of cellular and molecular biology to cancer research and aging, from the identification and validation of biomarkers to new therapies and targeted mechanistic studies.

Potential topics include but are not limited to the following:

• Changes in signaling pathways in cancer and aging;
• Factors that influence signal transduction in cancer and aging;
• Roles of microRNAs (miRs) and long noncoding RNAs (lncRNAs) in cancer and aging;
• New possibilities for targeted therapies in cancer and aging;
• Optimization of cancer combination therapies.

Dr. Melchiorre Cervello
Prof. Dr. James Albert McCubrey
Dr. Giuseppa Augello
Dr. Antonella Cusimano
Collection Editors

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