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Special Issue "Pathophysiological Mechanisms in Ocular Graft-versus-Host Disease"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 26 February 2021.

Special Issue Editors

Prof. Dr. Philipp Steven
Guest Editor
Department of Ophthalmology, Division for Dry-Eye and Ocular GvHD, Medical Faculty, University of Cologne, 50937 Cologne, Germany
Interests: ocular GvHD, Dry Eye Disease, Non-invasive Ocular Surface Imaging, Drug-development
Prof. Dr. Victor L. Perez
Guest Editor
Foster Center for Ocular Immunology at Duke Eye Center, USA
Interests: ocular GVHD, Immune Mediated Eye Diseases, Dry Eye Syndrome, Tear Flow Cytometry and Diagnostic, basic immune mechanisms ocular GVHD, Donor reactive T cells, immune therapy; keywords

Special Issue Information

Dear Colleagues,

Ocular graft-versus-host disease is a rapidly progressing multifactorial inflammatory disease of the entire eye and its adnexae. Approximately 50% of patients undergoing allogeneic hematopoietic stem cell transplantation suffer from acute and/or chronic ocular GvHD. Although foreseeable in its onset, there are limitations in diagnostic and therapeutic options based on a lack of knowledge in the understanding of its pathophysiology. As ocular GvHD is a “rare disease”, currently there is little interest in specific drug development and clinical trial implementation. Furthermore, mandatory treatment guidelines differ from region to region or are lacking entirely.

This Special Issue, titled “Pathophysiology of Ocular Graft-versus-Host Disease” is dedicated to providing an overview on current research efforts that focus on the understanding of ocular GvHD pathomechanisms. We hereby would like to invite you to submit original research papers and reviews on, but not limited to, new findings on immunomechanisms, molecular key players, pathomechanisms, risk factors, biomarkers, and therapeutic targets. This will include experimental cell or organ cultures models, animal studies. Phase I clinical trials or retrospective studies highlighting or proposing new molecular mechanisms are also welcome.   

Prof. Dr. Philipp Steven
Prof. Dr. Victor L. Perez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Ocular GvHD
  • Immunopathogenesis
  • Animal models
  • Angiogenesis
  • Risk factors
  • Biomarkers
  • Immune therapies
  • Dermatological and GI Tract GVHD

Published Papers

This special issue is now open for submission.
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