Metastasis Inhibition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 October 2020) | Viewed by 36262
Special Issue Editors
Interests: mammary cancer; metastasis; inhibition; lymphangiogenesis; premetastatic niche; mouse
Special Issues, Collections and Topics in MDPI journals
2 Translational Research Program, Osaka Medical College, Takatsuki 569-8686, Japan
Interests: microRNA; oligonucleotide therapeutics; warburg effect; extracellular vesicles; gastrointestinal cancer
Special Issue Information
Dear Colleagues,
Cancer metastasis is a common biological nature of malignant tumors and finally leads to death of the hosts. Therefore, effective antimetastatic therapy and chemopreventive treatments are desperately required. However, the pathobiology of metastasis greatly differs between cancer types. Various microenvironmental factors, genetic events, and molecules participate in the formation of cancer metastasis. In order to achieve metastasis inhibition, we have to conquer the complexity of cancers.
Cancer metastasis has been classified into different stages beginning from local invasion, intravasation, circulation in blood stream or lymphatic flow, extravasation, colonization, and metastasis. In other words, dissemination of cancer cells occurs in different ways: local direct invasion and/or migration via blood and lymphatic vessels. Few cancer cells which pass all these steps can colonize distant sites, i.e., establishment of metastasis. Therapeutics targeting responsible factors in each stage are considerable strategies. We hope that this Special Issue will encourage many researchers to share their knowledge and some ideas on metastasis inhibition research.
Prof. Masa-Aki Shibata
Dr. Kohei Taniguchi
Guest Editors
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Keywords
- cancer
- malignant tumor
- metastasis
- antimetastasis
- antitumor
- inhibition
- therapeutics
- angiogenesis
- lymphangiogenesis
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