Skip to Content

316,548 Results Found

  • Review
  • Open Access
116 Citations
17,031 Views
29 Pages

Specification of BMP Signaling

  • Joachim Nickel and
  • Thomas D. Mueller

5 December 2019

Bone Morphogenetic Proteins (BMPs) together with the Growth and Differentiation Factors (GDFs) form the largest subgroup of the Transforming Growth Factor (TGF)β family and represent secreted growth factors, which play an essential role in many...

(This article belongs to the Special Issue TGF-beta/BMP Signaling Pathway)
  • Article
  • Open Access
5 Citations
3,481 Views
52 Pages

Specification Mining over Temporal Data

  • Giacomo Bergami,
  • Samuel Appleby and
  • Graham Morgan

14 September 2023

Current specification mining algorithms for temporal data rely on exhaustive search approaches, which become detrimental in real data settings where a plethora of distinct temporal behaviours are recorded over prolonged observations. This paper propo...

(This article belongs to the Special Issue Advances in Database Engineered Applications 2023)
  • Article
  • Open Access
603 Views
35 Pages

A Unified Specification Process for Graphical Domain-Specific Languages in Model-Based Systems Engineering

  • Katharina Polanec,
  • Simon Eschlberger,
  • Markus Peter,
  • David Hoffmann and
  • Arndt Lüder

17 June 2026

Rising complexity in cyber-physical systems development exposes challenges in the consistent and reusable specification of graphical domain-specific languages (DSLs). Despite the benefits of model-based systems engineering (MBSE), the absence of a st...

(This article belongs to the Section Systems Engineering)
  • Review
  • Open Access
18 Citations
9,317 Views
25 Pages

Muscles control body movement and locomotion, posture and body position and soft tissue support. Mesoderm derived cells gives rise to 700 unique muscles in humans as a result of well-orchestrated signaling and transcriptional networks in specific tim...

(This article belongs to the Special Issue Crosstalk between FGF, TGF-β, BMP, and Wnt Signaling Pathways during Development)
  • Review
  • Open Access
7 Citations
2,250 Views
15 Pages

Auxin Orchestrates Germ Cell Specification in Arabidopsis

  • Tian-Ying Yu,
  • Ping Wang,
  • Yue Lv,
  • Bo Wang and ,
  • Ming-Ri Zhao and
  • Xin-Wei Dong
  • + 1 author+ 0 author

The initiation and specification of germline cells are crucial for plant reproduction and the continuity of species. In Arabidopsis thaliana, auxin plays a vital role in guiding the transition of somatic cells into germline fate, orchestrating the sp...

(This article belongs to the Special Issue Plant Hormone Signaling)
  • Article
  • Open Access
17 Citations
6,975 Views
20 Pages

Automated Specification-Based Testing of REST APIs

  • Ovidiu Baniaș,
  • Diana Florea,
  • Robert Gyalai and
  • Daniel-Ioan Curiac

9 August 2021

Nowadays, REpresentational State Transfer Application Programming Interfaces (REST APIs) are widely used in web applications, hence a plethora of test cases are developed to validate the APIs calls. We propose a solution that automates the generation...

(This article belongs to the Special Issue Selected Papers from the International Symposium on Electronics and Telecommunications ISETC 2020)
  • Article
  • Open Access
1 Citations
5,964 Views
13 Pages

Development of a Framework to Understand Tables in Engineering Specification Documents

  • Valentin Agossou,
  • Hyo-Won Suh,
  • Heejung Lee and
  • Jae Hyun Lee

5 September 2020

Several works have been done in the last decades for understanding tables in documents, but most of them were not specifically designed to understand tables in engineering specification documents. Tables in engineering specifications have characteris...

(This article belongs to the Section Computing and Artificial Intelligence)
  • Article
  • Open Access
3 Citations
3,529 Views
22 Pages

19 June 2022

Product derivation is the process of building a specific product from a software product line. Effective product derivation can improve software reuse productivity. Existing methods can only obtain abstract feature models, lacking detailed specificat...

(This article belongs to the Special Issue Requirements Engineering: Practice and Research)
  • Article
  • Open Access
7 Citations
5,195 Views
17 Pages

The generation of standardized requirements specification documents plays a crucial role in software processes. However, the manual composition of software requirements specifications is a laborious and time-consuming task, often leading to errors th...

(This article belongs to the Special Issue Applications of Big Data and AI)
  • Feature Paper
  • Article
  • Open Access
1,027 Views
15 Pages

4 April 2026

Integrated information theory (IIT) starts from the existence of consciousness and characterizes its essential properties: every experience is intrinsic, specific, unitary, definite, and structured. IIT then formulates existence and its essential pro...

(This article belongs to the Collection Advances in Integrated Information Theory)
  • Article
  • Open Access
8 Citations
3,805 Views
14 Pages

During development, mesodiencephalic dopaminergic (mdDA) neurons form into different molecular subsets. Knowledge of which factors contribute to the specification of these subsets is currently insufficient. In this study, we examined the role of Tcf4...

(This article belongs to the Special Issue Dopamine in Health and Disease)
  • Review
  • Open Access
527 Views
21 Pages

Understanding the Specification Mechanism of the Megaspore Mother Cell in Arabidopsis

  • Lian Yu,
  • Simin Ma,
  • Xinpeng Xi,
  • Peiyang He and
  • Hanyang Cai

3 September 2026

The megaspore mother cell (MMC) is the founding cell of the plant female germline, and its specification is a critical step in sexual reproduction of flowering plants. Recent advances in single-cell transcriptomics, live imaging, and gene editing hav...

(This article belongs to the Section Developmental and Reproductive Biology)
  • Article
  • Open Access
8 Citations
4,813 Views
19 Pages

Specification of Glazings for Façades Based on Spectrophotometric Characterization of Transmittance

  • Helenice Maria Sacht,
  • Luís Bragança,
  • Manuela Almeida and
  • Rosana Caram

13 May 2021

The correct specification of glazings for façades can reduce the energy consumption in buildings. The heat exchange occurs through transparent surfaces and radiation reaches the building as light and heat. Therefore, glazings significantly contribute...

(This article belongs to the Section Energy Sustainability)
  • Article
  • Open Access
17 Citations
4,642 Views
10 Pages

Specification Testing of Production in a Stochastic Frontier Model

  • Xu Guo,
  • Gao-Rong Li,
  • Michael McAleer and
  • Wing-Keung Wong

30 August 2018

Parametric production frontier functions are frequently used in stochastic frontier models, but there do not seem to be any empirical test statistics for the plausibility of this application. In this paper, we develop procedures to test whether or no...

(This article belongs to the Special Issue Risk Measures with Applications in Finance and Economics)
  • Article
  • Open Access
21 Citations
4,006 Views
13 Pages

20 June 2023

The proposed method for tire specification character recognition based on the YOLOv5 network aimed to address the low efficiency and accuracy of the current character recognition methods. The approach involved making three major modifications to the...

  • Article
  • Open Access
1 Citations
629 Views
28 Pages

SMDEVC: Specification-Based Misbehavior Detection for Electric Vehicle Charging Stations

  • Hoonyong Park,
  • Vincent Abella,
  • Jiyoon Kim,
  • Seunghwan Ju and
  • Ilsun You

3 June 2026

Electric vehicle (EV) chargers are often deployed in public spaces, making them easily accessible targets for cyber attackers. Moreover, EV chargers are components of EV charging infrastructure in which IT and OT domains coexist; thus, if they are co...

  • Article
  • Open Access
257 Views
31 Pages

15 October 2026

Vibe coding uses repeated natural-language prompts and minimal code review in large language model (LLM)-based development. Development may end before sufficient client–LLM context co-construction occurs. We propose CO-constructed SPECification...

(This article belongs to the Topic Applications of NLP, AI, and ML in Software Engineering)
  • Article
  • Open Access
2 Citations
5,081 Views
22 Pages

10 September 2022

Histogram equalization is one of the basic image processing tasks for contrast enhancement, and its generalized version is histogram specification, which accepts arbitrary shapes of target histograms including uniform distributions for histogram equa...

(This article belongs to the Section Color, Multi-spectral, and Hyperspectral Imaging)
  • Article
  • Open Access
6 Citations
3,066 Views
19 Pages

7 February 2021

Specification-based testing methods generate test data without the knowledge of the structure of the program. However, the quality of these test data are not well ensured to detect bugs when non-functional changes are introduced to the program. To ge...

(This article belongs to the Special Issue Mathematics in Software Reliability and Quality Assurance)
  • Article
  • Open Access
4 Citations
3,650 Views
20 Pages

Mobile Application Software Requirements Specification from Consumption Values

  • Mohammad Derawi,
  • Gonca Gokce Menekse Dalveren and
  • Nergiz Ercil Cagiltay

In today’s society, mobile applications are becoming more popular and providing several advantages. However, users will resist using a product regardless of how well-tested or solid it is if the wrong requirements are implemented. Understanding...

(This article belongs to the Section Computer Science & Engineering)
  • Article
  • Open Access
5 Citations
5,720 Views
17 Pages

10 June 2017

The definition of a Life Cycle Assesment (LCA) for a building or an urban area is a complex task due to the inherent complexity of all the elements that must be considered. Furthermore, a multidisciplinary approach is required due to the different so...

(This article belongs to the Section Sustainable Engineering and Science)
  • Article
  • Open Access
30 Citations
7,554 Views
12 Pages

5 November 2015

The wnt signaling pathway is an intercellular communication mechanism essential in cell-fate specification, tissue patterning and regional-identity specification. A βcatenin-dependent signal specifies the AP (Anteroposterior) axis of planarians, both...

(This article belongs to the Special Issue Molecular and Cellular Basis of Regeneration and Tissue Repair)
  • Article
  • Open Access
2,171 Views
15 Pages

19 March 2025

A model specification test is a statistical procedure used to assess whether a given statistical model accurately represents the underlying data-generating process. The smoothing-based nonparametric specification test is widely used due to its effici...

(This article belongs to the Special Issue Advances in Statistical Simulation and Computing)
  • Article
  • Open Access
5 Citations
5,285 Views
14 Pages

26 August 2021

Defects such as the duality and the incompleteness in natural language software requirements specification have a significant impact on the success of software projects. By now, many approaches have been proposed to assist requirements analysts to id...

(This article belongs to the Special Issue Requirements Engineering: Practice and Research)
  • Article
  • Open Access
2 Citations
6,726 Views
21 Pages

Removing Specification Errors from the Usual Formulation of Binary Choice Models

  • P.A.V.B. Swamy,
  • I-Lok Chang,
  • Jatinder S. Mehta,
  • William H. Greene and ,
  • Stephen G. Hall and
  • George S. Tavlas
  • + 1 author+ 0 author

We develop a procedure for removing four major specification errors from the usual formulation of binary choice models. The model that results from this procedure is different from the conventional probit and logit models. This difference arises as a...

  • Review
  • Open Access
16 Citations
16,586 Views
29 Pages

Understanding the Molecular Circuitry of Cell Lineage Specification in the Early Mouse Embryo

  • Anna Bergsmedh,
  • Mary E. Donohoe,
  • Rebecca-Ayme Hughes and
  • Anna-Katerina Hadjantonakis

13 July 2011

Pluripotent stem cells hold great promise for cell-based therapies in regenerative medicine. However, critical to understanding and exploiting mechanisms of cell lineage specification, epigenetic reprogramming, and the optimal environment for maintai...

(This article belongs to the Special Issue The Early Mouse Embryo as a Model Organism for Reprogramming)
  • Article
  • Open Access
22 Citations
4,290 Views
14 Pages

The efficient acquisition and dissemination of information are crucial in building information modeling (BIM). Current BIM models face significant challenges, including inadequate modeling techniques, poorly defined information requirements, and low...

(This article belongs to the Section Construction Management, and Computers & Digitization)
  • Article
  • Open Access
21 Citations
8,698 Views
34 Pages

30 April 2021

Requirements specification includes technical concerns of an information system and is used throughout its life cycle. It allows for sharing the vision of the system among stakeholders and facilitates its development and operation processes. Natural...

(This article belongs to the Special Issue Requirements Engineering: Practice and Research)
  • Article
  • Open Access
384 Views
36 Pages

2 October 2026

Hydraulic turbines increasingly operate under variable hydraulic regimes, creating a need for condition monitoring (CM) systems that support diagnostics and predictive maintenance, rather than only protection or threshold-based alarms. However, senso...

(This article belongs to the Special Issue Flexibility Solutions and Innovations for Sustainable Hydropower)
  • Article
  • Open Access
14 Citations
6,443 Views
18 Pages

It is generally accepted that epigenetic modifications, such as DNA and histone methylations, affect transcription and that a gene’s transcription feeds back on its epigenetic profile. Depending on the epigenetic modification, positive and nega...

  • Article
  • Open Access
11 Citations
3,587 Views
15 Pages

Data-Driven Scenario Specification for AV–VRU Interactions at Urban Roundabouts

  • Andreas Keler,
  • Patrick Malcolm,
  • Georgios Grigoropoulos,
  • Seyed Abdollah Hosseini and ,
  • Heather Kaths,
  • Fritz Busch and
  • Klaus Bogenberger
  • + 2 authors+ 0 author

24 July 2021

Detailed specifications of urban traffic from different perspectives and scales are crucial for understanding and predicting traffic situations from the view of an autonomous vehicle (AV). We suggest a data-driven specification scheme for maneuvers a...

(This article belongs to the Special Issue Roundabouts Performance in Road Transport Networks—Future Challenges, Problems and Issues)
  • Article
  • Open Access
15 Citations
4,786 Views
15 Pages

SMDFbs: Specification-Based Misbehavior Detection for False Base Stations

  • Hoonyong Park,
  • Philip Virgil Berrer Astillo,
  • Yongho Ko,
  • Yeongshin Park and ,
  • Taeguen Kim and
  • Ilsun You
  • + 1 author+ 0 author

29 November 2023

The advancement of cellular communication technology has profoundly transformed human life. People can now watch high-definition videos anytime, anywhere, and aim for the implementation of advanced autonomous driving capabilities. However, the sustai...

(This article belongs to the Special Issue Feature Papers in the Internet of Things Section 2023)
  • Article
  • Open Access
1 Citations
2,924 Views
19 Pages

6 December 2021

This paper describes our best practices related to hybrid power system (HPS) development, with a focus on the specification development phase. The HPS specifications are based on the main development goals of our security robot, which place top prior...

(This article belongs to the Special Issue Cutting-Edge Technologies of the Unmanned Aerial Vehicles (UAVs))
  • Article
  • Open Access
3 Citations
4,456 Views
13 Pages

2 August 2018

The goal of edge-histogram specification is to find an image whose edge image has a histogram that matches a given edge-histogram as much as possible. Mignotte has proposed a non-convex model for the problem in 2012. In his work, edge magnitudes of a...

(This article belongs to the Special Issue Advanced Numerical Methods in Applied Sciences)
  • Article
  • Open Access
6 Citations
3,794 Views
23 Pages

BiLSTM-CRF-KG: A Construction Method of Software Requirements Specification Graph

  • Zhengdi Wang,
  • Jeng-Shyang Pan,
  • Qinyin Chen and
  • Shuangyuan Yang

13 June 2022

A requirement analysis is the basis and source of software system development, and its accuracy, consistency and completeness are the keys to determining software quality. However, at present, most software requirements specifications are prepared ma...

(This article belongs to the Section Computing and Artificial Intelligence)
  • Article
  • Open Access
199 Citations
13,893 Views
19 Pages

A Specification-Based IDS for Detecting Attacks on RPL-Based Network Topology

  • Anhtuan Le,
  • Jonathan Loo,
  • Kok Keong Chai and
  • Mahdi Aiash

Routing Protocol for Low power and Lossy network (RPL) topology attacks can downgrade the network performance significantly by disrupting the optimal protocol structure. To detect such threats, we propose a RPL-specification, obtained by a semi-auto...

  • Article
  • Open Access
1 Citations
5,908 Views
31 Pages

16 September 2015

Estimation results obtained by parametric models may be seriously misleading when the model is misspecified or poorly approximates the true model. This study proposes a test that jointly tests the specifications of multiple response probabilities in...

  • Article
  • Open Access
4 Citations
6,817 Views
18 Pages

27 September 2022

User satisfaction with a product plays a direct role in the purchasing decisions. With the enrichment of material life and the growth of individual requirements, this satisfaction is derived from the requirement for functionality to aesthetics. Conve...

(This article belongs to the Collection Computational Product Design with Artificial Intelligence)
  • Article
  • Open Access
23 Citations
2,573 Views
18 Pages

28 November 2020

The quality characteristics with unilateral specifications include the smaller-the-better (STB) and larger-the-better (LTB) quality characteristics. Roundness, verticality, and concentricity are categorized into the STB quality characteristics, while...

(This article belongs to the Special Issue Fuzzy Applications in Industrial Engineering)
  • Review
  • Open Access
174 Views
21 Pages

17 October 2026

The megaspore mother cell (MMC), the initial cell of the female germline in flowering plants, differentiates from a distal subepidermal somatic cell in the ovule. Positional signals guide this process, yet the mechanisms by which multiple signals int...

(This article belongs to the Collection Feature Papers in Plant Cell Biology)
  • Article
  • Open Access
32 Citations
8,813 Views
28 Pages

29 August 2012

Maintaining inter-actor connectivity is extremely crucial in mission-critical applications of Wireless Sensor and Actor Networks (WSANs), as actors have to quickly plan optimal coordinated responses to detected events. Failure of a critical actor par...

(This article belongs to the Special Issue Ubiquitous Sensing)
  • Article
  • Open Access
2,066 Views
19 Pages

Potentially Preventable Hospitalisations (PPH) is a widely used indicator of the effectiveness of non-hospital care. Specified using the International Classification of Diseases (ICD) coding, PPH comprises a suite of health conditions that could have...

(This article belongs to the Special Issue Advances in Nursing and Medical Education)
  • Article
  • Open Access
16 Citations
2,665 Views
11 Pages

Developing a Novel Fuzzy Evaluation Model by One-Sided Specification Capability Indices

  • Wei Lo,
  • Chun-Ming Yang,
  • Kuei-Kuei Lai,
  • Shao-Yu Li and
  • Chi-Han Chen

11 May 2021

When all of the one-sided specification indices of each quality characteristic reach the requirements of the process quality level, they can ensure that the process capability of the product meets the requirements of the process quality level. This s...

(This article belongs to the Special Issue Fuzzy Applications in Industrial Engineering)
  • Article
  • Open Access
6 Citations
5,140 Views
17 Pages

Modeling Schistosoma japonicum Infection under Pure Specification Bias: Impact of Environmental Drivers of Infection

  • Andrea L. Araujo Navas,
  • Frank Osei,
  • Lydia R. Leonardo,
  • Ricardo J. Soares Magalhães and
  • Alfred Stein

Uncertainties in spatial modeling studies of schistosomiasis (SCH) are relevant for the reliable identification of at-risk populations. Ecological fallacy occurs when ecological or group-level analyses, such as spatial aggregations at a specific admi...

(This article belongs to the Section Infectious Disease Epidemiology)
  • Article
  • Open Access
10 Citations
3,290 Views
21 Pages

22 March 2025

Building information modeling (BIM) relies on well-defined information requirements to ensure data availability, accurate data exchange, and model consistency. The information delivery specification (IDS) schema has emerged as a standard for structur...

(This article belongs to the Section Construction Management, and Computers & Digitization)
  • Article
  • Open Access
2 Citations
3,506 Views
22 Pages

5 February 2024

At present, the automatic generation of tolerance types based on rule-based reasoning has an obvious characteristic: for the same assembly feature, tolerance items are recommended that satisfy all feature characteristics, with a large number of recom...

(This article belongs to the Special Issue Advances in Structural Optimization)
  • Article
  • Open Access
6 Citations
3,581 Views
19 Pages

Pareto-Optimised Fog Storage Services with Novel Service-Level Agreement Specification

  • Petar Kochovski,
  • Uroš Paščinski,
  • Vlado Stankovski and
  • Mojca Ciglarič

24 March 2022

(1) Background: Cloud storage is often required for successful operation of novel smart applications, relying on data produced by the Internet of Things (IoT) devices. Big Data processing tasks and management operations for such applications require...

(This article belongs to the Special Issue Innovative Applications of Big Data and Cloud Computing)
  • Article
  • Open Access
4 Citations
2,862 Views
13 Pages

During embryonic development, cell-fate specification gives rise to dedicated lineages that underlie tissue formation. In olfactores, which comprise tunicates and vertebrates, the cardiopharyngeal field is formed by multipotent progenitors of both ca...

(This article belongs to the Special Issue Ascidian Early Development)
  • Article
  • Open Access
6 Citations
3,245 Views
18 Pages

10 January 2024

Software specifications are of great importance to improve the quality of software. To automatically mine specifications from software systems, some specification mining approaches based on finite-state automatons have been proposed. However, these a...

(This article belongs to the Section Algorithms for Multidisciplinary Applications)
  • Article
  • Open Access
12 Citations
3,421 Views
13 Pages

11 December 2021

In requirement engineering, an important issue is how to transform and tailor the informal system requirements of users or customers into more structured specification documents, which are then used by the software developers. In addition, it is both...

(This article belongs to the Section Computing and Artificial Intelligence)

of 6,331