TGF-beta/BMP Signaling Pathway

Dear Colleagues,

The TGF-β superfamily plays key roles in development and tissue homeostasis, controlling the maintenance and regeneration of mature tissues. Cytokines belonging to this family can be multifunctional (TGF-β and BMPs) or develop highly specialized functions (AMH, GDF8) and they control a variety of cellular processes, such us proliferation, differentiation, cell death, adhesion and movement, metabolism, pluripotency, and stemness.

TGF-β family members share a common pathway, the Smad pathway, that controls gene expression in a context dependent fashion since this pathway can be finely tuned at different levels. TGF-β can also activate non-Smad signaling pathways that modulate downstream cellular responses.

Giving the wide array of cell regulatory functions of TGF-β superfamily, dysregulation of this signaling pathway is, as expected, at the grounds of many developmental and degenerative diseases, having an intricate role in tissue fibrosis and cancer.

In this Special Issue, we aim to recapitulate current knowledge of this vast field and to give the possibility of sharing novel data on the multiple aspects of TGF-β signaling.

We invite experts to contribute with research papers and critical reviews on TGF-β/BMP signaling: From regulation and crosstalk to biological relevance in metazoan organisms both in physiological and pathological contexts, and how it can be modulated in disease to gain a therapeutic benefit.

Dr. Isabel Fabregat
Dr. Aránzazu Sánchez
Dr. Blanca Herrera
Guest Editors

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