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  • Article
  • Open Access
3 Citations
5,945 Views
13 Pages

Proton Acceleration by Ultrashort Intense Laser Interaction with Microstructured Snow Targets

  • Elad Schleifer,
  • Zohar Henis,
  • Mordechai Botton,
  • Omer Shavit and ,
  • Daniel F. Gordon and
  • Arie Zigler
  • + 1 author+ 0 author

26 August 2015

Enhanced proton acceleration to high energy by relatively modest ultrashort laser pulses and structured dynamic plasma snow targets was demonstrated experimentally. High proton yield emitted to narrow solid angle with energies of up 25 MeV were detec...

(This article belongs to the Special Issue Casting Light on Cancer Therapy)
  • Article
  • Open Access
1,144 Views
10 Pages

We report on laser fusion research with nanotechnology-improved targets embedded in special polymers. The results of the last three years are reviewed here, including laser matter interaction craters, laser infrared breakdown spectroscopy, and Raman...

(This article belongs to the Special Issue Particles and Plasmas in Strong Fields, Part 1)
  • Article
  • Open Access
8 Citations
5,057 Views
12 Pages

A Few MeV Laser-Plasma Accelerated Proton Beam in Air Collimated Using Compact Permanent Quadrupole Magnets

  • Fernando Brandi,
  • Luca Labate,
  • Daniele Palla,
  • Sanjeev Kumar and ,
  • Lorenzo Fulgentini,
  • Petra Koester,
  • Federica Baffigi,
  • Massimo Chiari,
  • Daniele Panetta and
  • Leonida Antonio Gizzi
  • + 5 authors+ 0 author

9 July 2021

Proton laser-plasma-based acceleration has nowadays achieved a substantial maturity allowing to seek for possible practical applications, as for example Particle Induced X-ray Emission with few MeV protons. Here we report about the design, implementa...

(This article belongs to the Special Issue Laser-Driven Accelerators, Radiations, and Their Applications)
  • Article
  • Open Access
9 Citations
5,622 Views
17 Pages

Advances in Spectral Distribution Assessment of Laser Accelerated Protons using Multilayer CR-39 Detectors

  • Andreea Groza,
  • Mihai Serbanescu,
  • Bogdan Butoi,
  • Elena Stancu and ,
  • Mihai Straticiuc,
  • Ion Burducea,
  • Adriana Balan,
  • Alecsandru Chirosca,
  • Bogdan Mihalcea and
  • Mihai Ganciu
  • + 5 authors+ 0 author

18 May 2019

We show that a spectral distribution of laser-accelerated protons can be extracted by analyzing the proton track diameters observed on the front side of a second CR-39 detector arranged in a stack. The correspondence between the proton track diameter...

(This article belongs to the Section Optics and Lasers)
  • Feature Paper
  • Article
  • Open Access
6 Citations
4,913 Views
13 Pages

8 August 2019

The idea of using a gas-mixture comprising atoms with a high mass number in order to increase proton energies in laser induced plasma acceleration at critical density is investigated by means of 2D PIC (Particle-In-Cell) simulations. Comparing and di...

(This article belongs to the Special Issue Modelling of Plasma Flow)
  • Article
  • Open Access
2 Citations
3,291 Views
15 Pages

Design and Implementation of an Energy Selector for Laser-Accelerated Protons

  • Alicia Reija,
  • David Esteban,
  • Aarón Alejo,
  • Jon Imanol Apiñaniz and ,
  • Adrián Bembibre,
  • José Benlliure,
  • Michael Ehret,
  • Javier García López,
  • M. Carmen Jiménez-Ramos and
  • Michael Seimetz
  • + 10 authors+ 5 authors

Highly intense bunches of protons and ions with energies of several MeV/u can be generated with ultra-short laser pulses focused on solid targets. In the most common interaction regime, target normal sheath acceleration, the spectra of these particle...

  • Article
  • Open Access
2,173 Views
11 Pages

GEANT4 Simulation of Proton Beam Properties from a Cyclotron Accelerator at King Chulalongkorn Memorial Hospital

  • Piyanud Thongjerm,
  • Ekkachai Kongmon,
  • Khwanjira Tangpong,
  • Phalakorn Khwansungnoen and ,
  • Sarinrat Wonglee,
  • Weerawat Pornroongruengchok and
  • Nantanat Chailanggar
  • + 2 authors+ 0 author

9 July 2025

The main objective of proton beam therapy is to precisely irradiate diseased tissue while minimizing damage to healthy cells. For effective treatment, the linear energy transfer (LET) is a key parameter in ensuring the destruction of diseased cells,...

  • Article
  • Open Access
703 Views
13 Pages

24 February 2026

Gas ionization chambers face significant challenges in diagnosing laser-accelerated proton beams due to severe space charge effects induced by high peak currents and broad energy dispersion. These effects typically cause electric field distortion, si...

(This article belongs to the Section Lasers, Light Sources and Sensors)
  • Article
  • Open Access
9 Citations
3,585 Views
10 Pages

Enhanced Proton Acceleration from Laser Interaction with a Tailored Nanowire Target

  • Yue Chao,
  • Lihua Cao,
  • Chunyang Zheng,
  • Zhanjun Liu and
  • Xiantu He

22 January 2022

Target normal sheath field acceleration via laser interaction with structured solid targets has been widely studied for its potential use in a wide range of applications. Here, a novel nanowire target with a corrugated front surface is proposed to im...

(This article belongs to the Special Issue Progress on Laser Plasma Interaction)
  • Article
  • Open Access
8 Citations
5,229 Views
11 Pages

Parametric Study of Proton Acceleration from Laser-Thin Foil Interaction

  • Mohammed Almassarani,
  • Sixu Meng,
  • Burgard Beleites,
  • Falk Ronneberger and ,
  • Gerhard G. Paulus and
  • Amrutha Gopal
  • + 1 author+ 0 author

2 October 2021

We experimentally investigated the accelerated proton beam characteristics such as maximum energy and number by varying the incident laser parameters. For this purpose, we varied the laser energy, focal spot size, polarization, and pulse duration. Th...

  • Article
  • Open Access
11 Citations
8,278 Views
22 Pages

Introduction of Research Work on Laser Proton Acceleration and Its Application Carried out on Compact Laser–Plasma Accelerator at Peking University

  • Dongyu Li,
  • Tang Yang,
  • Minjian Wu,
  • Zhusong Mei and ,
  • Kedong Wang,
  • Chunyang Lu,
  • Yanying Zhao,
  • Wenjun Ma,
  • Kun Zhu and
  • Xueqing Yan
  • + 11 authors+ 6 authors

28 January 2023

Laser plasma acceleration has made remarkable progress in the last few decades, but it also faces many challenges. Although the high gradient is a great potential advantage, the beam quality of the laser accelerator has a certain gap, or it is differ...

(This article belongs to the Special Issue Progress in Laser Accelerator and Future Prospects)
  • Article
  • Open Access
840 Views
18 Pages

Metallic nanoantennas are promising structures for enhancing energy transfer in high-intensity laser–matter interactions, especially in nanoplasmonic-assisted fusion. Under ultrashort laser pulses, they generate strong localized fields, modify...

(This article belongs to the Special Issue Particles and Plasmas in Strong Fields, Part 1)
  • Article
  • Open Access
3,434 Views
23 Pages

Design of a 162.5 MHz Superconducting Radio-Frequency Quadrupole for High-Intensity Proton Acceleration

  • Ying Xia,
  • Zhi Wang,
  • Yuanrong Lu,
  • Feng Zhu and ,
  • Meiyun Han and
  • Tianhao Wei
  • + 1 author+ 0 author

22 December 2023

Superconducting (SC) radio-frequency quadrupoles (RFQs) have exhibited outstanding performance in transmitting and accelerating high-current continuous-wave (CW) ion beams. They can complete beam acceleration at a much higher gradient and with much l...

  • Article
  • Open Access
2,458 Views
9 Pages

Recently, it has been experimentally shown that the sheath acceleration of protons from ultra-thin metal targets irradiated by sub-picosecond laser pulses of intensities above 1021 W/cm2 is suppressed compared to well-established models. This detrime...

(This article belongs to the Section Instrumentation and Facilities)
  • Feature Paper
  • Article
  • Open Access
50 Citations
6,776 Views
20 Pages

The AWAKE Run 2 Programme and Beyond

  • Edda Gschwendtner,
  • Konstantin Lotov,
  • Patric Muggli,
  • Matthew Wing and ,
  • Riccardo Agnello,
  • Claudia Christina Ahdida,
  • Maria Carolina Amoedo Goncalves,
  • Yanis Andrebe,
  • Oznur Apsimon and
  • Giovanni Zevi Della Porta
  • + 97 authors+ 92 authors

12 August 2022

Plasma wakefield acceleration is a promising technology to reduce the size of particle accelerators. The use of high energy protons to drive wakefields in plasma has been demonstrated during Run 1 of the AWAKE programme at CERN. Protons of energy 400...

(This article belongs to the Special Issue Recent Advance in Accelerator and Particle Physics)
  • Article
  • Open Access
13 Citations
4,102 Views
13 Pages

A New Low-Energy Proton Irradiation Facility to Unveil the Mechanistic Basis of the Proton-Boron Capture Therapy Approach

  • Valerio Ricciardi,
  • Pavel Bláha,
  • Raffaele Buompane,
  • Giuseppina Crescente and ,
  • Giacomo Cuttone,
  • Lucio Gialanella,
  • Katarina Michaličková,
  • Severina Pacifico,
  • Giuseppe Porzio and
  • Lorenzo Manti
  • + 5 authors+ 0 author

16 December 2021

Protontherapy (PT) is a fast-growing cancer therapy modality thanks to much-improved normal tissue sparing granted by the charged particles’ inverted dose-depth profile. Protons, however, exhibit a low biological effectiveness at clinically rel...

(This article belongs to the Section Applied Physics General)
  • Review
  • Open Access
2 Citations
5,130 Views
9 Pages

2 November 2016

Hadronic models of blazar emission constitute an interesting alternative to the more popular leptonic ones. Using the BL Lac object Mrk 421 as a characteristic example, we present two distinct ways of modeling the spectral energy distribution of blaz...

(This article belongs to the Special Issue Blazars through Sharp Multi-wavelength Eyes)
  • Review
  • Open Access
116 Citations
19,230 Views
42 Pages

Towards Laser Driven Hadron Cancer Radiotherapy: A Review of Progress

  • Ken W. D. Ledingham,
  • Paul R. Bolton,
  • Naoya Shikazono and
  • C.-M. Charlie Ma

19 September 2014

It has been known for about sixty years that proton and heavy ion therapy is a very powerful radiation procedure for treating tumors. It has an innate ability to irradiate tumors with greater doses and spatial selectivity compared with electron and...

(This article belongs to the Special Issue Casting Light on Cancer Therapy)
  • Feature Paper
  • Article
  • Open Access
88 Citations
29,411 Views
7 Pages

In-Target Proton–Boron Nuclear Fusion Using a PW-Class Laser

  • Daniele Margarone,
  • Julien Bonvalet,
  • Lorenzo Giuffrida,
  • Alessio Morace and ,
  • Vasiliki Kantarelou,
  • Marco Tosca,
  • Didier Raffestin,
  • Philippe Nicolai,
  • Antonino Picciotto and
  • Dimitri Batani
  • + 11 authors+ 6 authors

28 January 2022

Nuclear reactions between protons and boron-11 nuclei (p–B fusion) that were used to yield energetic α-particles were initiated in a plasma that was generated by the interaction between a PW-class laser operating at relativistic intensiti...

(This article belongs to the Special Issue Laser-Driven Accelerators, Radiations, and Their Applications)
  • Proceeding Paper
  • Open Access
2 Citations
1,474 Views
6 Pages

First Result of the High Repetition Operation in J-PARC MR

  • Takaaki Yasui,
  • Susumu Igarashi,
  • Yoichi Sato and
  • Hideaki Hotchi

We performed beam studies with a cycling period of 1.36 s in the main ring synchrotron (MR) of Japan Proton Accelerator Research Complex (J-PARC) after hardware upgrade to enable high repetition operation. After optics tuning, we have successfully co...

(This article belongs to the Proceedings of The 23rd International Workshop on Neutrinos from Accelerators)
  • Article
  • Open Access
14 Citations
4,187 Views
11 Pages

Evaluating the Durability of Perfluorosulfonic Acid Membranes in Fuel Cells Using Combined Open-Circuit Voltage-Accelerated Stability Testing

  • Juniko Nur Pratama,
  • Hyunwoo Song,
  • Hansung Kim,
  • Hyejin Lee and ,
  • Dongwon Shin and
  • Byungchan Bae
  • + 1 author+ 0 author

9 May 2024

This study evaluates the chemical and mechanical durability of membranes used in proton exchange membrane fuel cells, highlighting the essential role of electrochemical tests in understanding the relationship between durability and performance. Our m...

(This article belongs to the Topic Nanomaterials for Fuel Cell Systems)
  • Article
  • Open Access
23 Citations
5,691 Views
14 Pages

The Measurement of the Neutron Yield of the 7Li(p,n)7Be Reaction in Lithium Targets

  • Marina Bikchurina,
  • Timofey Bykov,
  • Dmitrii Kasatov,
  • Iaroslav Kolesnikov and ,
  • Aleksandr Makarov,
  • Ivan Shchudlo,
  • Evgeniia Sokolova and
  • Sergey Taskaev
  • + 3 authors+ 0 author

24 August 2021

A compact accelerator-based neutron source has been proposed and created at the Budker Institute of Nuclear Physics in Novosibirsk, Russia. An original design tandem accelerator is used to provide a proton beam. The neutron flux is generated as a res...

(This article belongs to the Special Issue Boron Neutron Capture Therapy: From Nuclear Physics to Biomedicine)
  • Article
  • Open Access
1,926 Views
10 Pages

EM Characterization of a Compact RFQ Cold Model Prototype Employing a New Power Injection Scheme

  • Marco A. López,
  • Joaquín Portilla,
  • Victor Etxebarria,
  • Iñigo Arredondo and
  • Jorge Feuchtwanger

The experimental and computational characterization of a cold model prototype designed to test the electromagnetic properties of a new RFQ (Radio-Frequency Quadrupole) cavity is reported. This cavity is intended to be an essential part of a compact,...

(This article belongs to the Section Experimental Physics and Instrumentation)
  • Article
  • Open Access
19 Citations
2,929 Views
10 Pages

27 July 2023

To study the durability of proton exchange membrane fuel cells (PEMFCs), the experiments were performed by using a 300 h accelerated stress test under vibration and non-vibration conditions. Before and after chronic operation, the polarization curve,...

(This article belongs to the Special Issue Nanostructured Electrodes for High-Performance Supercapacitors and Batteries)
  • Article
  • Open Access
6 Citations
2,741 Views
11 Pages

Application of Proton Irradiation in the Study of Accelerated Radiation Ageing in a GaAs Semiconductor

  • Igor Neuhold,
  • Pavol Noga,
  • Stanislav Sojak,
  • Martin Petriska and ,
  • Jarmila Degmova,
  • Vladimir Slugen and
  • Vladimir Krsjak
  • + 2 authors+ 0 author

27 January 2023

Proton irradiation experiments have been used as a surrogate for studying radiation effects in numerous materials for decades. The abundance and accessibility of proton accelerators make this approach convenient for conducting accelerated radiation a...

(This article belongs to the Special Issue Experimental Simulation and Characterization of Radiation Damage in Materials)
  • Article
  • Open Access
18 Citations
4,440 Views
16 Pages

20 July 2021

The detrimental effects of the catalyst degradation on the overall envisaged lifetime of low-temperature proton-exchange membrane fuel cells (LT-PEMFCs) represent a significant challenge towards further lowering platinum loadings and simultaneously a...

(This article belongs to the Special Issue Development of Advanced Models for Analysis and Simulation of Fuel Cells)
  • Article
  • Open Access
2 Citations
2,430 Views
14 Pages

27 October 2022

Beam-driven plasma wakefield accelerators typically use the external injection to ensure controllable beam quality at injection. However, the externally injected witness bunch may exhibit a non-Gaussian transverse density distribution. Using particle...

(This article belongs to the Section Applied Physics General)
  • Review
  • Open Access
53 Citations
10,959 Views
24 Pages

Materials and Life Science Experimental Facility at the Japan Proton Accelerator Research Complex IV: The Muon Facility

  • Wataru Higemoto,
  • Ryosuke Kadono,
  • Naritoshi Kawamura,
  • Akihiro Koda and ,
  • Kenji M. Kojima,
  • Shunsuke Makimura,
  • Shiro Matoba,
  • Yasuhiro Miyake,
  • Koichiro Shimomura and
  • Patrick Strasser
  • + 5 authors+ 0 author

A muon experimental facility, known as the Muon Science Establishment (MUSE), is one of the user facilities at the Japan Proton Accelerator Research Complex, along with those for neutrons, hadrons, and neutrinos. The MUSE facility is integrated into...

(This article belongs to the Collection Facilities)
  • Review
  • Open Access
62 Citations
11,343 Views
26 Pages

Materials and Life Science Experimental Facility at the Japan Proton Accelerator Research Complex I: Pulsed Spallation Neutron Source

  • Hiroshi Takada,
  • Katsuhiro Haga,
  • Makoto Teshigawara,
  • Tomokazu Aso and ,
  • Shin-Ichiro Meigo,
  • Hiroyuki Kogawa,
  • Takashi Naoe,
  • Takashi Wakui,
  • Motoki Ooi and
  • Masatoshi Futakawa
  • + 6 authors+ 1 author

At the Japan Proton Accelerator Research Complex (J-PARC), a pulsed spallation neutron source provides neutrons with high intensity and narrow pulse width pulse to promote researches on a variety of science in the Materials and Life Science Experimen...

(This article belongs to the Collection Facilities)
  • Article
  • Open Access
15 Citations
3,479 Views
10 Pages

Accelerated Photodegradation of Organic Pollutants over BiOBr/Protonated g-C3N4

  • Juanjuan Liu,
  • Heng Guo,
  • Haoyong Yin,
  • Qiulin Nie and
  • Shihui Zou

25 September 2022

Interfacial engineering has emerged as an effective strategy to optimize the photocatalytic activity of heterojunctions. Herein, the interface between graphitic carbon nitride (g-C3N4) and BiOBr was readily regulated by a protonation treatment. The s...

(This article belongs to the Special Issue Feature Papers in Catalysis in Organic and Polymer Chemistry)
  • Article
  • Open Access
3 Citations
4,942 Views
18 Pages

Design of a Miniaturized Electron Cyclotron Resonance Ion Source for High-Voltage Proton Accelerator

  • Hua-Fei Yu,
  • Zi-Feng He,
  • Ming-Hua Zhao,
  • Wei-Shi Wan and ,
  • Huan-Ling Liu,
  • Yue Wu,
  • Wen-Zhuang Lv,
  • Da-Yong Zhou and
  • Huan-Ting Lu
  • + 4 authors+ 0 author

31 July 2023

The Electron Cyclotron Resonance (ECR) ion source fulfills high-current, high-efficiency, and compactness requirements for high-voltage proton accelerators. It is a cathode-free source that uses microwaves to heat a magnetically confined plasma, so t...

(This article belongs to the Special Issue Advances in Particle Acceleration: Novel Techniques, Instruments and Applications)
  • Article
  • Open Access
6 Citations
2,731 Views
11 Pages

Key Components Degradation in Proton Exchange Membrane Fuel Cells: Unraveling Mechanisms through Accelerated Durability Testing

  • Keguang Yao,
  • Li Wang,
  • Xin Wang,
  • Xiaowu Xue and ,
  • Shuai Li,
  • Hanwen Zhang,
  • Zhengnan Li,
  • Yanpu Li,
  • Gangping Peng and
  • Haijiang Wang
  • + 6 authors+ 1 author

14 September 2024

In the process of promoting the commercialization of proton exchange membrane fuel cells, the long-term durability of the fuel cell has become a key consideration. While existing durability tests are critical for assessing cell performance, they are...

(This article belongs to the Special Issue Recent Advances in Green Hydrogen Production and Hydrogen-Based Energy Storage Technology)
  • Article
  • Open Access
291 Views
21 Pages

Numerical Evaluation of Proton-Exchange Membrane Fuel Cell Degradation in Real Driving Conditions and Accelerated Stress Tests

  • José A. Lalangui,
  • Joaquín de la Morena,
  • Marcos López-Juárez and
  • Enrique J. Sanchis

13 September 2026

Proton-exchange membrane fuel cell degradation is one of the factors that limit the deployment of this technology in the automotive market. Accelerated Stress Tests (ASTs) are the standard tool for assessing durability during design and development p...

(This article belongs to the Special Issue Next-Generation Fuel Cell Technologies for Transportation Applications)
  • Article
  • Open Access
10 Citations
3,979 Views
12 Pages

Internal Microscopic Diagnosis of Accelerated Aging of Proton Exchange Membrane Water Electrolysis Cell Stack

  • Chi-Yuan Lee,
  • Chia-Hung Chen,
  • Guo-Bin Jung,
  • Shih-Chun Li and
  • Yi-Zhen Zeng

4 December 2020

The hydrogen production reaction of the proton exchange membrane (PEM) water electrolysis cell stack is the reverse reaction of the fuel cell, but the water electrolysis operation requires high pressure, and the high pressure decomposes hydrogen mole...

(This article belongs to the Special Issue Smart Sensors 2020)
  • Article
  • Open Access
6 Citations
6,212 Views
13 Pages

The Anti-Tumor Effect of Boron Neutron Capture Therapy in Glioblastoma Subcutaneous Xenograft Model Using the Proton Linear Accelerator-Based BNCT System in Korea

  • Il Hyeok Seo,
  • Jeongwoo Lee,
  • Dasom Na,
  • Hyunhye Kyung and ,
  • Jieun Yang,
  • Sangbong Lee,
  • Sang June Jeon,
  • Jae Won Choi,
  • Kyu Young Lee and
  • Se Hyun Kim
  • + 8 authors+ 3 authors

19 August 2022

Boron neutron capture therapy (BNCT) is a radiation therapy that selectively kills cancer cells and is being actively researched and developed around the world. In Korea, development of the proton linear accelerator-based BNCT system has completed de...

(This article belongs to the Special Issue The Latest in Boron Neutron Capture Therapy Radiobiology)
  • Review
  • Open Access
106 Citations
18,906 Views
59 Pages

Materials and Life Science Experimental Facility (MLF) at the Japan Proton Accelerator Research Complex II: Neutron Scattering Instruments

  • Kenji Nakajima,
  • Yukinobu Kawakita,
  • Shinichi Itoh,
  • Jun Abe and ,
  • Kazuya Aizawa,
  • Hiroyuki Aoki,
  • Hitoshi Endo,
  • Masaki Fujita,
  • Kenichi Funakoshi and
  • Hideki Yoshizawa
  • + 59 authors+ 54 authors

The neutron instruments suite, installed at the spallation neutron source of the Materials and Life Science Experimental Facility (MLF) at the Japan Proton Accelerator Research Complex (J-PARC), is reviewed. MLF has 23 neutron beam ports and 21 instr...

(This article belongs to the Collection Facilities)
  • Review
  • Open Access
22 Citations
8,538 Views
35 Pages

Materials and Life Science Experimental Facility at the Japan Proton Accelerator Research Complex III: Neutron Devices and Computational and Sample Environments

  • Kaoru Sakasai,
  • Setsuo Satoh,
  • Tomohiro Seya,
  • Tatsuya Nakamura and ,
  • Kentaro Toh,
  • Hideshi Yamagishi,
  • Kazuhiko Soyama,
  • Dai Yamazaki,
  • Ryuji Maruyama and
  • Masao Watanabe
  • + 26 authors+ 21 authors

Neutron devices such as neutron detectors, optical devices including supermirror devices and 3He neutron spin filters, and choppers are successfully developed and installed at the Materials Life Science Facility (MLF) of the Japan Proton Accelerator...

(This article belongs to the Collection Facilities)
  • Article
  • Open Access
14 Citations
5,686 Views
14 Pages

27 January 2025

To expand the applications of proton exchange membrane fuel cell (PEMFC) stacks, it is essential to address the issue of their short lifetime. Various studies are being conducted to improve this limitation, and efficient methods for verifying durabil...

  • Article
  • Open Access
6 Citations
3,937 Views
8 Pages

Optically Switchable MeV Ion/Electron Accelerator

  • Itamar Cohen,
  • Yonatan Gershuni,
  • Michal Elkind,
  • Guy Azouz and ,
  • Assaf Levanon and
  • Ishay Pomerantz
  • + 1 author+ 0 author

10 June 2021

The versatility of laser accelerators in generating particle beams of various types is often promoted as a key applicative advantage. These multiple types of particles, however, are generated on vastly different irradiation setups, so that switching...

(This article belongs to the Special Issue Laser-Driven Accelerators, Radiations, and Their Applications)
  • Article
  • Open Access
41 Citations
6,421 Views
13 Pages

14 March 2024

In this work, we focus on the degradation of membrane electrode assemblies (MEAs) in proton-exchange membrane water electrolysis (PEMWE) induced by different accelerated stress tests (ASTs), including constant-current mode, square-wave mode, and sola...

(This article belongs to the Special Issue Advanced Electrocatalytic Materials for Energy and Environmental Applications)
  • Article
  • Open Access
4 Citations
4,612 Views
14 Pages

Proton pump inhibitors (PPIs) are the mainstay for treatment of acid-related diseases. This study developed a mechanism-based pharmacokinetic (PK) and pharmacodynamics (PD) model with ilaprazole as case drug, so as to support and accelerate the devel...

(This article belongs to the Special Issue Model-Informed Drug Discovery and Development)
  • Article
  • Open Access
9 Citations
3,974 Views
13 Pages

Loss of electrochemical surface area in proton-exchange membrane is of large practical importance, since membrane degradation largely affects the durability and life of fuel cells. In this paper, the electrokinetic model developed by Holby and Morgan...

(This article belongs to the Section Environmental Technology)
  • Article
  • Open Access
17 Citations
9,478 Views
14 Pages

Development of Focusing Plasma Mirrors for Ultraintense Laser-Driven Particle and Radiation Sources

  • Robbie Wilson,
  • Martin King,
  • Ross J. Gray,
  • David C. Carroll and ,
  • Rachel J. Dance,
  • Nicholas M. H. Butler,
  • Chris Armstrong,
  • Steve J. Hawkes,
  • Robert J. Clarke and
  • Paul McKenna
  • + 8 authors+ 3 authors

Increasing the peak intensity to which high power laser pulses are focused can open up new regimes of laser-plasma interactions, resulting in the acceleration of ions to higher energies and more efficient generation of energetic photons. Low f-number...

(This article belongs to the Special Issue Laser-Driven Quantum Beams)
  • Article
  • Open Access
3 Citations
5,982 Views
12 Pages

Development of the LHCb VELO Detector Modules into a Standalone, Non-Invasive Online Beam Monitor for Medical Accelerators

  • Roland Schnuerer,
  • Jacinta Yap,
  • Hao Zhang,
  • Tomasz Cybulski and ,
  • Tony Smith,
  • Guido Haefeli,
  • Olivier Girard,
  • Tomasz Szumlak and
  • Carsten Welsch
  • + 4 authors+ 0 author

Knowledge of the beam properties in proton therapy through beam monitoring is essential, ensuring an effective dose delivery to the patient. In clinical practice, currently used interceptive ionisation chambers require daily calibration and suffer fr...

  • Article
  • Open Access
1 Citations
1,451 Views
17 Pages

Low-Intensity, Short-Duration Proton Irradiation Enhances Oxidative Stress Sensitivity of Aspergillus nidulans, with Transcriptomic Data Indicating Downregulation of Antioxidative Enzyme Genes

  • Máté Szarka,
  • Ildikó Vig,
  • András Fenyvesi,
  • Barnabás Cs. Gila and ,
  • Károly Antal,
  • Zita Szikszai,
  • István Pócsi and
  • Tamás Emri
  • + 3 authors+ 0 author

19 February 2026

Fungi regularly occur on spacecrafts, posing a serious risk to humans and equipment. In this study, we characterized how the model organism Aspergillus nidulans responds to low-intensity, short-duration proton irradiation designed to simulate a solar...

(This article belongs to the Section Fungal Cell Biology, Metabolism and Physiology)
  • Article
  • Open Access
4 Citations
3,454 Views
30 Pages

This study tackles the individual and joint effect of alpha-tocopherol and hydroxytyrosol acetate on the oxidation of sunflower oil submitted to accelerated storage conditions at intermediate temperature, in order to deepen the understanding of antio...

(This article belongs to the Special Issue Lipid Oxidation in Food and Antioxidant Strategies)
  • Article
  • Open Access
1 Citations
2,934 Views
32 Pages

Detection of Solar Neutrons and Solar Neutron Decay Protons

  • Yasushi Muraki,
  • Tatsumi Koi,
  • Satoshi Masuda,
  • Yutaka Matsubara and ,
  • Pedro Miranda,
  • Shoko Miyake,
  • Tsuguya Naito,
  • Ernesto Ortiz,
  • Akitoshi Oshima and
  • Kyoko Watanabe
  • + 10 authors+ 5 authors

28 December 2023

Solar flares are broadly classified as impulsive or gradual. Ions accelerated in a gradual flare are thought to be accelerated through a shock acceleration mechanism, but the particle acceleration process in an impulsive flare is still largely unexpl...

(This article belongs to the Section Solar and Stellar Physics)
  • Article
  • Open Access
4 Citations
2,970 Views
19 Pages

In Vivo Radiobiological Investigations with the TOP-IMPLART Proton Beam on a Medulloblastoma Mouse Model

  • Daniela Giovannini,
  • Cinzia De Angelis,
  • Maria Denise Astorino,
  • Emiliano Fratini and ,
  • Evaristo Cisbani,
  • Giulia Bazzano,
  • Alessandro Ampollini,
  • Massimo Piccinini,
  • Enrico Nichelatti and
  • Simonetta Pazzaglia
  • + 11 authors+ 6 authors

Protons are now increasingly used to treat pediatric medulloblastoma (MB) patients. We designed and characterized a setup to deliver proton beams for in vivo radiobiology experiments at a TOP-IMPLART facility, a prototype of a proton-therapy linear a...

(This article belongs to the Section Molecular Oncology)
  • Article
  • Open Access
1 Citations
3,676 Views
12 Pages

Investigation of Pre-Pulse Effects on Ultrashort-Pulse Laser Interaction with Structured Targets

  • Artem Kim,
  • Indranuj Dey,
  • Alexander Bespaly,
  • Pavel Komm and ,
  • Assaf Shaham,
  • Jenya Papeer,
  • Mordechai Botton and
  • Arie Zigler
  • + 3 authors+ 0 author

30 December 2024

The role of pre-plasma in the efficient generation of protons by intense laser-matter interaction from structured targets is investigated. Optimal energy coupling between laser and plasma is found by varying the fluence and arrival time of an indepen...

(This article belongs to the Section Optics and Lasers)
  • Article
  • Open Access
868 Views
12 Pages

18 December 2025

Laser-driven ion acceleration in dense, hydrogen-rich media can be significantly enhanced by embedding metallic nanoantennas that support localized surface plasmon (LSP) resonances. Using large-scale particle-in-cell (PIC) simulations with the EPOCH...

(This article belongs to the Special Issue Selected Papers from the 14th International Conference on New Frontiers in Physics (ICNFP 2025))

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