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10.3390/life12081264
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Article

The Anti-Tumor Effect of Boron Neutron Capture Therapy in Glioblastoma Subcutaneous Xenograft Model Using the Proton Linear Accelerator-Based BNCT System in Korea

by
Il Hyeok Seo
1,
Jeongwoo Lee
1,2,
Dasom Na
1,
Hyunhye Kyung
1,
Jieun Yang
1,
Sangbong Lee
1,
Sang June Jeon
1,
Jae Won Choi
1,
Kyu Young Lee
1,
Jungyu Yi
1,3,
Jaehwan Han
1,
Mooyoung Yoo
1 and
Se Hyun Kim
1,*
1
A-BNCT Center, Dawonmedax, Incheon 21988, Korea
2
Department of Pharmacy, ERICA Campus, Hanyang University, Ansan 15588, Korea
3
Department of Nuclear Engineering, Hanyang University, Seoul 04763, Korea
*
Author to whom correspondence should be addressed.
Life 2022, 12(8), 1264; https://doi.org/10.3390/life12081264
Submission received: 27 May 2022 / Revised: 16 August 2022 / Accepted: 17 August 2022 / Published: 19 August 2022
(This article belongs to the Special Issue The Latest in Boron Neutron Capture Therapy Radiobiology)
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Abstract

Boron neutron capture therapy (BNCT) is a radiation therapy that selectively kills cancer cells and is being actively researched and developed around the world. In Korea, development of the proton linear accelerator-based BNCT system has completed development, and its anti-cancer effect in the U-87 MG subcutaneous xenograft model has been evaluated. To evaluate the efficacy of BNCT, we measured 10B-enriched boronophenylalanine (BPA) uptake in U-87 MG, FaDu, and SAS cells and evaluated cell viability by clonogenic assays. In addition, the boron concentration in the tumor, blood, and skin on the U-87 MG xenograft model was measured, and the tumor volume was measured for 4 weeks after BNCT. In vitro, the intracellular boron concentration was highest in the order of SAS, FaDu, and U-87 MG, and cell survival fractions decreased depending on the BPA treatment concentration and neutron irradiation dose. In vivo, the tumor volume was significantly decreased in the BNCT group compared to the control group. This study confirmed the anti-cancer effect of BNCT in the U-87 MG subcutaneous xenograft model. It is expected that the proton linear accelerator-based BNCT system developed in Korea will be a new option for radiation therapy for cancer treatment.
Keywords: BNCT; BPA; linear accelerator; radiation therapy; Korea BNCT; BPA; linear accelerator; radiation therapy; Korea

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MDPI and ACS Style

Seo, I.H.; Lee, J.; Na, D.; Kyung, H.; Yang, J.; Lee, S.; Jeon, S.J.; Choi, J.W.; Lee, K.Y.; Yi, J.; et al. The Anti-Tumor Effect of Boron Neutron Capture Therapy in Glioblastoma Subcutaneous Xenograft Model Using the Proton Linear Accelerator-Based BNCT System in Korea. Life 2022, 12, 1264. https://doi.org/10.3390/life12081264

AMA Style

Seo IH, Lee J, Na D, Kyung H, Yang J, Lee S, Jeon SJ, Choi JW, Lee KY, Yi J, et al. The Anti-Tumor Effect of Boron Neutron Capture Therapy in Glioblastoma Subcutaneous Xenograft Model Using the Proton Linear Accelerator-Based BNCT System in Korea. Life. 2022; 12(8):1264. https://doi.org/10.3390/life12081264

Chicago/Turabian Style

Seo, Il Hyeok, Jeongwoo Lee, Dasom Na, Hyunhye Kyung, Jieun Yang, Sangbong Lee, Sang June Jeon, Jae Won Choi, Kyu Young Lee, Jungyu Yi, and et al. 2022. "The Anti-Tumor Effect of Boron Neutron Capture Therapy in Glioblastoma Subcutaneous Xenograft Model Using the Proton Linear Accelerator-Based BNCT System in Korea" Life 12, no. 8: 1264. https://doi.org/10.3390/life12081264

APA Style

Seo, I. H., Lee, J., Na, D., Kyung, H., Yang, J., Lee, S., Jeon, S. J., Choi, J. W., Lee, K. Y., Yi, J., Han, J., Yoo, M., & Kim, S. H. (2022). The Anti-Tumor Effect of Boron Neutron Capture Therapy in Glioblastoma Subcutaneous Xenograft Model Using the Proton Linear Accelerator-Based BNCT System in Korea. Life, 12(8), 1264. https://doi.org/10.3390/life12081264

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