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11,042 Results Found

  • Article
  • Open Access
23 Citations
5,230 Views
16 Pages

1 December 2020

This article begins with a brief outline of recent advances in the application of computer modeling to sustainability research, identifying important gaps in coverage and associated limits in methodological capability, particularly in regard to takin...

(This article belongs to the Special Issue Modelling and Simulation of Human-Environment Interactions)
  • Perspective
  • Open Access
9 Citations
4,717 Views
14 Pages

Keep the Human in the Loop: Arguments for Human Assistance in the Synthesis of Simulation Data for Robot Training

  • Carina Liebers,
  • Pranav Megarajan,
  • Jonas Auda,
  • Tim C. Stratmann and ,
  • Max Pfingsthorn,
  • Uwe Gruenefeld and
  • Stefan Schneegass
  • + 2 authors+ 0 author

Robot training often takes place in simulated environments, particularly with reinforcement learning. Therefore, multiple training environments are generated using domain randomization to ensure transferability to real-world applications and compensa...

  • Article
  • Open Access
6 Citations
4,117 Views
19 Pages

23 February 2022

When planning lunar rover missions, it is important to develop intuition and driving skills for unfamiliar environments before incurring the costs of reaching the moon. Simulators make it possible to operate in environments that have the physical cha...

(This article belongs to the Topic Human–Machine Interaction)
  • Article
  • Open Access
21 Citations
6,226 Views
19 Pages

Numerical Simulation of Microwave Ablation in the Human Liver

  • John Gorman,
  • Winston Tan and
  • John Abraham

14 February 2022

Microwave thermal ablation was developed as an alternative to other forms of thermal ablation procedures. The objective of this study is to numerically model a microwave ablation probe operating at the 2.45 GHz level using the finite element and fini...

(This article belongs to the Section Biological Processes and Systems)
  • Article
  • Open Access
66 Citations
7,400 Views
16 Pages

Microplastics as Vectors of Chromium and Lead during Dynamic Simulation of the Human Gastrointestinal Tract

  • Verónica Godoy,
  • Antonio Martínez-Férez,
  • María Ángeles Martín-Lara,
  • José Antonio Vellido-Pérez and ,
  • Mónica Calero and
  • Gabriel Blázquez
  • + 1 author+ 0 author

11 June 2020

The human body is exposed to the ingestion of microplastics that are often contaminated with other substances, which can be released into our body. In this work, a dynamic in-vitro simulator of the gastrointestinal tract based on a membrane reactor h...

(This article belongs to the Special Issue Plastic Waste and Pollution)
  • Article
  • Open Access
6 Citations
3,417 Views
18 Pages

Human and Environmental Factors Analysis in Traffic Using Agent-Based Simulation

  • Ariadna Claudia Moreno,
  • Mailyn Moreno,
  • Cynthia Porras and
  • Juan Pavón

9 March 2023

Traffic congestion is a frequent problem on most urban roads. This may be due to incorrect configuration of traffic signals but planning analysis should also include a study of human behavior, which, often imprudent, contributes to traffic congestion...

(This article belongs to the Special Issue Optimization and Simulation Techniques for Transportation)
  • Article
  • Open Access
8 Citations
4,043 Views
17 Pages

31 August 2020

While the social sustainability of built environments is an essential aspect of architectural design education, systemic experiments still lack empirical pedagogy. Therefore, factors of social sustainability are hardly reflected in students’ pr...

(This article belongs to the Special Issue Towards a Sustainable Life: Smart and Green Design in Buildings and Community)
  • Article
  • Open Access
212 Views
51 Pages

26 October 2026

Agentic coding systems increasingly automate repository inspection, tool use, code generation, testing, and repair, but the human commonly remains responsible for decomposing the task, directing workflow progression, and judging completion. This limi...

(This article belongs to the Special Issue Computational Modeling and Intelligent Simulation of Next-Generation Energy Systems (2nd Edition))
  • Article
  • Open Access
443 Views
18 Pages

Simulation-Based Design of Process Parameters for Human–Machine Collaborative Aircraft Assembly Riveting

  • Ji Li,
  • Junjie Dan,
  • Yaling Tian,
  • Min Ling and ,
  • Heng Zhao,
  • Weiqiang Mo,
  • Yi Luo and
  • Yaoming Zhou
  • + 3 authors+ 0 author

7 August 2026

In aircraft assembly, riveting is a critical joining method that directly determines structural integrity, fatigue life, and overall airframe reliability. With the increasing adoption of human–machine collaborative systems for complex assembly...

(This article belongs to the Special Issue Design, Manufacturing, Measurement, and Quality Control Technologies for Assembly)
  • Article
  • Open Access
2,377 Views
20 Pages

28 December 2024

A rapidly growing body of experimental evidence in the literature shows that the effects of humans interacting with vibrating structures, other humans, and their surrounding environment can be critical for reliable estimation of structural vibrations...

(This article belongs to the Section Physical Sensors)
  • Article
  • Open Access
362 Views
27 Pages

The transition from Industry 4.0 to Industry 5.0 is increasing the need for design approaches that place human centrality, safety, and ergonomics at the core of system development. In this context, immersive simulation is evolving from a training-ori...

  • Proceeding Paper
  • Open Access
128 Views
10 Pages

16 October 2026

By introducing a data-driven human–machine collaboration performance evaluation Model (HMCPEM) that utilizes multiple regression and Monte Carlo simulation, the effectiveness and dependability of collaborative decision-making in smart agricultu...

  • Article
  • Open Access
3 Citations
2,758 Views
24 Pages

EMG-Based Simulation for Optimization of Human-in-the-Loop Control in Simple Robotic Walking Assistance

  • Arash Mohammadzadeh Gonabadi,
  • Nathaniel H. Hunt and
  • Farahnaz Fallahtafti

Exoskeletons offer promising solutions for enhancing human mobility; however, personalizing assistance parameters to optimize physiological outcomes remains challenging. Human-in-the-loop (HIL) optimization has emerged as an effective strategy for ta...

  • Article
  • Open Access
8 Citations
3,561 Views
11 Pages

Evaluation of the Binding Mechanism of Human Defensin 5 in a Bacterial Membrane: A Simulation Study

  • Tadsanee Awang,
  • Phoom Chairatana,
  • Ranjit Vijayan and
  • Prapasiri Pongprayoon

17 November 2021

Human α-defensin 5 (HD5) is a host-defense peptide exhibiting broad-spectrum antimicrobial activity. The lipopolysaccharide (LPS) layer on the Gram-negative bacterial membrane acts as a barrier to HD5 insertion. Therefore, the pore formation and bind...

(This article belongs to the Special Issue Applications of Computational Modeling in Disease, Infection and Drug Design)
  • Article
  • Open Access
6 Citations
3,745 Views
35 Pages

Validating Flow-Based Arrival Management for En Route Airspace: Human-In-The-Loop Simulation Experiment with ESCAPE Light Simulator

  • Katsuhiro Sekine,
  • Daiki Iwata,
  • Philippe Bouchaudon,
  • Tomoaki Tatsukawa and ,
  • Kozo Fujii,
  • Koji Tominaga and
  • Eri Itoh
  • + 2 authors+ 0 author

22 October 2024

The advancement of Arrival MANager (AMAN) is crucial for addressing the increasing complexity and demand of modern airspace. This study evaluates the operational feasibility and effectiveness of an innovative AMAN designed for en route airspace, the...

(This article belongs to the Special Issue Future Airspace and Air Traffic Management Design)
  • Article
  • Open Access
3 Citations
2,590 Views
14 Pages

6 August 2022

Crew fatigue from standing posture motion, caused by ship motion, can lead to marine accidents. Therefore, the mechanism of fatigue in crew members ought to be elucidated. The standing posture of humans is maintained by postural state detection throu...

(This article belongs to the Special Issue Assistive Technology and Biomechatronics Engineering)
  • Article
  • Open Access
2 Citations
1,165 Views
20 Pages

1 October 2025

As stroke is becoming more frequent nowadays, cutting edge rehabilitation approaches are required to recover upper limb functionalities and to support patients during daily activities. Recently, focus has moved to robotic rehabilitation; however, the...

(This article belongs to the Special Issue Advances in Mechanism and Machine Science Within the IFIT 2024 Conference)
  • Article
  • Open Access
7 Citations
1,936 Views
24 Pages

Prediction of the Human EP1 Receptor Binding Site by Homology Modeling and Molecular Dynamics Simulation

  • Behnoush ZARE,
  • Armin MADADKAR-SOBHANI,
  • Siavoush DASTMALCHI and
  • Masoud MAHMOUDIAN

7 August 2011

The prostanoid receptor EP1 is a G-protein-coupled receptor (GPCR) known to be involved in a variety of pathological disorders such as pain, fever and inflammation. These receptors are important drug targets, but design of subtype specific agonists a...

  • Article
  • Open Access
2 Citations
2,914 Views
15 Pages

5 September 2025

Background: Individuals who are victimized and exploited by the heinous crimes of human trafficking (HT) access healthcare during their exploitation, yet gaps in education on HT content exist in prelicensure nursing programs. This study explored the...

(This article belongs to the Special Issue Break the Chains: Global Efforts in Eradication and Prevention of Human Trafficking)
  • Article
  • Open Access
1 Citations
1,097 Views
17 Pages

6 February 2026

Simulation-based training systems are increasingly deployed to prepare learners for complex, safety-critical, and dynamic work environments. While advances in computing have enabled immersive and data-rich simulations, many systems remain optimized f...

(This article belongs to the Special Issue Innovative Research in Human–Computer Interactions)
  • Article
  • Open Access
368 Views
20 Pages

2 September 2026

Realistic head-orientation behavior contributes to the credibility of virtual human agents in scenario-based simulations. Conventional finite state machine (FSM) agents often rely on manually defined perception rules, producing repetitive head motion...

(This article belongs to the Section Computing and Artificial Intelligence)
  • Article
  • Open Access
756 Views
18 Pages

18 January 2026

This work presents the first study addressing two-dimensional numerical simulations of acoustic wave scattering involving a simplified human body model placed inside an enclosed cabin. The simulations utilise the µ-diff backscattering algorithm...

(This article belongs to the Section Acoustics and Vibrations)
  • Article
  • Open Access
4 Citations
2,305 Views
19 Pages

Investigating the Effect of Human Factors on the Underground Mine Evacuation Process Using Agent-Based Simulation

  • Peter Chidi Augustine,
  • Amin Moniri-Morad,
  • Mahdi Shahsavar and
  • Javad Sattarvand

17 December 2024

Human factors play a critical role in underground mine evacuations, significantly impacting performance during emergencies. Traditional mine evacuation strategies rely on predetermined routes and static signs, but these methods do not account for the...

  • Article
  • Open Access
6 Citations
2,990 Views
17 Pages

Toxic trace elements in farmland soils are potential threats to human health. In this study, we collected soil samples from the farmlands of southern Guangzhou. We used a sequential indicator simulation (SIS) to deal with the problem of skewed distri...

(This article belongs to the Section Environmental Sustainability and Applications)
  • Article
  • Open Access
3 Citations
5,509 Views
21 Pages

10 June 2023

The impact of human resource management (HRM) on corporate growth is a crucial research topic, especially for growth-oriented firms. This paper aims to study how different payment policies (such as recruitment and dismissal strategies and payment pla...

(This article belongs to the Section Systems Practice in Social Science)
  • Article
  • Open Access
1 Citations
2,322 Views
25 Pages

Low-Cost Strain-Gauge Force-Sensing Sidestick for 6-DoF Flight Simulation: Design and Human-in-the-Loop Evaluation

  • Patrik Rožić,
  • Milan Vrdoljak,
  • Karolina Krajček Nikolić and
  • Jurica Ivošević

18 July 2025

Modern fly-by-wire (FBW) aircraft demand high-fidelity simulation systems for research and training, yet existing force-sensing solutions are often prohibitively expensive. This study presents the design, development, and validation of a low-cost, re...

(This article belongs to the Topic Innovation and Inventions in Aerospace and UAV Applications)
  • Article
  • Open Access
527 Views
33 Pages

Task-Driven Virtual Human Simulation for Performance-Based Accessibility Assessment of Built Environments

  • Vasileios Sidiropoulos,
  • Thomas Varelas,
  • Athanasios Tsakiris,
  • Chatzipanagiotidou Panagiota and ,
  • Dimitrios Bechtsis,
  • Emmannouil Zidianakis,
  • Eirini Kontaki,
  • Antonios Agapakis,
  • Nikolaos Partarakis and
  • Dimitrios Tzovaras
  • + 6 authors+ 1 author

27 July 2026

Accessibility evaluation in built environments increasingly requires performance-based methods that capture dynamic user–environment interaction rather than static compliance with dimensional standards. Existing computational approaches, includ...

  • Article
  • Open Access
1 Citations
574 Views
15 Pages

20 April 2026

Human error in evacuation guidance systems can significantly affect evacuation performance, particularly in complex underground environments where large numbers of occupants are concentrated. While previous studies have focused on optimizing evacuati...

  • Article
  • Open Access
3 Citations
2,923 Views
23 Pages

3 October 2024

This study evaluates the dynamic performance of a reference footbridge under human–structure interaction (HSI) effects using real-time hybrid simulation (RTHS). The footbridge, designed with precise multi-axial dynamic sensitivity, is tested un...

(This article belongs to the Special Issue Advances in Foot Biomechanics and Gait Analysis)
  • Article
  • Open Access
530 Views
36 Pages

3 July 2026

As artificial intelligence becomes increasingly embedded in healthcare operations, governance can no longer be treated solely as a static set of principles or regulatory requirements. This study proposes a Human-Centered Experience Engineering (HCEE)...

(This article belongs to the Section Artificial Intelligence and Digital Systems Engineering)
  • Article
  • Open Access
3 Citations
1,675 Views
30 Pages

11 March 2026

Retaining the green workforce, employees driving sustainability and environmental innovation, is essential for organizational resilience and long-term environmental goals. While prior Green HRM research has primarily relied on survey-based methodolog...

(This article belongs to the Section Economic and Business Aspects of Sustainability)
  • Article
  • Open Access
1 Citations
1,717 Views
34 Pages

3 December 2025

To address the efficiency and safety challenges arising from the mixed operation of autonomous and human-driven container trucks during the automation transformation of traditional container terminals, this study designed a simulation-based optimizat...

(This article belongs to the Section Coastal Engineering)
  • Article
  • Open Access
7 Citations
2,672 Views
17 Pages

22 August 2023

The inherited disorder oculocutaneous albinism type 1 (OCA1) is caused by mutations in the TYR gene encoding tyrosinase (Tyr), an enzyme essential to producing pigments throughout the human body. The intramelanosomal domain of Tyr consists of the cys...

(This article belongs to the Collection Feature Papers in Molecular Biophysics)
  • Article
  • Open Access
18 Citations
4,831 Views
16 Pages

1 September 2021

Oxidative stress is one of the significant precursors of various metabolic diseases such as diabetes, Parkinson’s disease, cardiovascular diseases, cancer, etc. Various scientific reports have indicated that secondary plant metabolites play an import...

(This article belongs to the Special Issue Phenolic Composition, Antioxidant Potential and Bioactive Potential of Natural Products)
  • Article
  • Open Access
3 Citations
1,586 Views
28 Pages

12 November 2025

Population aging and rising rehabilitation demands highlight the need for advanced assistive devices to improve mobility in individuals with motor impairments. Existing back-support lifting nursing beds often lack adequate human–machine adaptab...

(This article belongs to the Special Issue Advanced Intelligent Systems and Biomimetics)
  • Review
  • Open Access
9 Citations
9,014 Views
12 Pages

2 March 2012

Metabolism is crucial to cell growth and proliferation. Deficiency or alterations in metabolic functions are known to be involved in many human diseases. Therefore, understanding the human metabolic system is important for the study and treatment of...

(This article belongs to the Special Issue Metabolic Network Models)
  • Article
  • Open Access
10 Citations
5,582 Views
20 Pages

A Novel Approach to Simulating Realistic Exoskeleton Behavior in Response to Human Motion

  • Zhejun Yao,
  • Seyed Milad Mir Latifi,
  • Carla Molz,
  • David Scherb and ,
  • Christopher Löffelmann,
  • Johannes Sänger,
  • Jörg Miehling,
  • Sandro Wartzack,
  • Andreas Lindenmann and
  • Robert Weidner
  • + 6 authors+ 1 author

1 February 2024

Simulation models are a valuable tool for exoskeleton development, especially for system optimization and evaluation. It allows an assessment of the performance and effectiveness of exoskeletons even at an early stage of their development without phy...

(This article belongs to the Section Neurorobotics)
  • Article
  • Open Access
1 Citations
4,217 Views
20 Pages

27 August 2022

Human-in-the-loop driving simulation aims to create the illusion of driving by stimulating the driver’s sensory systems in as realistic conditions as possible. However, driving simulators can only produce a subset of the sensory stimuli that wo...

(This article belongs to the Section Computer Science & Engineering)
  • Article
  • Open Access
453 Views
20 Pages

Expressway interchange guide signs must support rapid route decisions under limited viewing time, high information load, and potential vehicle occlusion. This study developed a human-centered framework for optimizing guide-sign information and presen...

(This article belongs to the Special Issue Safer Roads Ahead: Exploring the Latest Innovations and Advancements in Road Design and Safety Technology, 2nd Edition)
  • Article
  • Open Access
45 Citations
5,635 Views
17 Pages

Identification of Natural Lead Compounds against Hemagglutinin-Esterase Surface Glycoprotein in Human Coronaviruses Investigated via MD Simulation, Principal Component Analysis, Cross-Correlation, H-Bond Plot and MMGBSA

  • Iqra Ali,
  • Muhammad Asif Rasheed,
  • Simona Cavalu,
  • Kashif Rahim and ,
  • Sana Ijaz,
  • Galal Yahya,
  • Lucky Poh Wah Goh and
  • Mihaela Simona Popoviciu
  • + 3 authors+ 0 author

The pandemic outbreak of human coronavirus is a global health concern that affects people of all ages and genders, but there is currently still no effective, approved and potential drug against human coronavirus, as many other coronavirus vaccines ha...

(This article belongs to the Special Issue Drug Discovery for Infectious Diseases)
  • Article
  • Open Access
664 Views
29 Pages

3 August 2026

AI-enabled simulation platforms are increasingly used for talent development, offering scalable, low-risk practice and algorithmic feedback for interpersonal HR capabilities such as difficult conversations, negotiation, and consultation. Yet HRD eval...

(This article belongs to the Special Issue Human Resource Development and Retention in the Digital Age: Best Practices and Technologies for Maximizing Positive Employee Outcomes)
  • Review
  • Open Access
66 Citations
13,492 Views
16 Pages

Simulator of the Human Intestinal Microbial Ecosystem (SHIME®): Current Developments, Applications, and Future Prospects

  • Wei Zhu,
  • Xiaoyong Zhang,
  • Dong Wang,
  • Qinghua Yao and ,
  • Guang-Lei Ma and
  • Xiaohui Fan
  • + 1 author+ 0 author

6 December 2024

The human gastrointestinal microbiota plays a vital role in maintaining host health and preventing diseases, prompting the creation of simulators to replicate this intricate system. The Simulator of the Human Intestinal Microbial Ecosystem (SHIME®...

(This article belongs to the Special Issue New and Emerging Treatment Strategies for Gastrointestinal Diseases)
  • Feature Paper
  • Article
  • Open Access
19 Citations
6,693 Views
11 Pages

This paper is intended to give an overview of the experiments to evaluate the cognitive load of the officer on watch (OOW) during a collision avoidance maneuver in a full-mission simulator. The main goal is to investigate the possibilities of recordi...

(This article belongs to the Special Issue Advances in Navigability and Mooring)
  • Article
  • Open Access
571 Views
23 Pages

22 June 2026

Forest fires cause societal damage, including injuries, burns, and the development and exacerbation of cardiorespiratory diseases. One of the damaging factors of forest fires is carbonaceous particles heated up to high temperatures. These particles a...

(This article belongs to the Special Issue Air Pollution Exposure and Its Impact on Human Health)
  • Article
  • Open Access
72 Citations
8,421 Views
15 Pages

13 October 2020

Inhibition of human pancreatic lipase, a crucial enzyme in dietary fat digestion and absorption, is a potent therapeutic approach for obesity treatment. In this study, human pancreatic lipase inhibitory activity of aurone derivatives was explored by...

(This article belongs to the Section Medicinal Chemistry)
  • Article
  • Open Access
9 Citations
4,099 Views
14 Pages

Analysis of Human Factors in Typical Accident Tests of Certain Type Flight Simulator

  • Guanghua Xing,
  • Yingjun Sun,
  • Fajiang He,
  • Pengcheng Wei and ,
  • Shicheng Wu,
  • Haojie Ren and
  • Zhixiong Chen
  • + 2 authors+ 0 author

3 February 2023

With the improvement of modern aviation equipment manufacturing technology, there are relatively few failures due to the unreliability of the aircraft. However, human factors which resulted in air crashes and unsafe events are raised. In this paper,...

(This article belongs to the Special Issue Recent Advances in Sustainability Development for Autonomous Systems)
  • Review
  • Open Access
9 Citations
4,321 Views
22 Pages

Chemical simulants have long been used in human trials of mass decontamination to determine the efficacy of decontamination interventions against more toxic agents. Until now, reliance has mostly been on individual chemicals as surrogates to specific...

(This article belongs to the Section Toxicology and Public Health)
  • Article
  • Open Access
4 Citations
4,220 Views
23 Pages

Insights to Human γD-Crystallin Unfolding by NMR Spectroscopy and Molecular Dynamics Simulations

  • Shu-Shun Hsueh,
  • S.-S. (Steven) Wang,
  • Shu-Han Chen,
  • Chia-Lin Wang and ,
  • W. (Josephine) Wu and
  • Ta-Hsien Lin
  • + 1 author+ 0 author

29 January 2022

Human γD-crystallin (HGDC) is an abundant lens protein residing in the nucleus of the human lens. Aggregation of this and other structural proteins within the lens leads to the development of cataract. Much has been explored on the stability an...

(This article belongs to the Collection Feature Papers in Molecular Biophysics)
  • Article
  • Open Access
5 Citations
5,690 Views
21 Pages

Simulation of Human Movement in Zero Gravity

  • Adelina Bärligea,
  • Kazunori Hase and
  • Makoto Yoshida

9 March 2024

In the era of expanding manned space missions, understanding the biomechanical impacts of zero gravity on human movement is pivotal. This study introduces a novel and cost-effective framework that demonstrates the application of Microsoft’s Azu...

(This article belongs to the Special Issue Biomechanical Analysis of Motion and Postural Control: Sensor Methods and Data Analytics—Third Edition)
  • Article
  • Open Access
454 Views
29 Pages

1 October 2026

With the increasing deployment of service robots in urban public spaces, this study examines how robot proportion (RP) and composite interaction scenarios affect pedestrian circulation performance. An AnyLogic agent-based model of Quancheng Square, J...

(This article belongs to the Topic Agentic and Generative AI for Spatial Data Science: Toward Intelligent, Interactive, and Predictive Urban Systems)

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