In this study, we have built a dual porosity/permeability model through accurately expressing the volumetric strain of matrix and fracture from a three-dimensional method which aims to reveal the reservoir permeability evolution during the process of...
Low permeability oil reservoirs hold an important position in the global oil resource reserves. They boast abundant reserves and serve as one of the crucial sources for crude oil reserve replacement in China and even the world. The mechanisms for imp...
Because geologic sedimentation and hydrofracturing processes are not homogeneous, the reservoirs of enhanced geothermal systems (EGSs) are also heterogeneous; this has a significant influence on the electricity generation performance of EGS. Presentl...
The development of low-permeability reservoirs faces significant challenges, particularly regarding low recovery rates. Conventional water injection is often limited by poor injectivity and low waterflood efficiency. As a key technology to enhance de...
A major concern for transdermal drug delivery systems is the low bioavailability of targeted drugs primarily caused by the skin’s barrier function. The resistance to the carrier matrix for the diffusion and transport of drugs, however, is routinely i...
Due to the complex physical properties of low-permeability glutenite reservoirs, the oil recovery rate with conventional development is low. Surfactants are effective additives for enhanced oil recovery (EOR) due to their good ability of wettability...
Enhanced oil recovery using nanoparticles is a promising method. However, when injected into a reservoir, nanoparticles can block pores and cause permeability damage. Therefore, enhancing their performance to lower the permeability damage effect is c...
This investigation was carried out to highlight the influence of the variation of permeability of the porous media with respect to the injection orientations during enhanced gas recovery (EGR) by CO2 injection using different core samples of differen...
Passive targeting is the foremost mechanism by which nanocarriers and drug-bearing macromolecules deliver their payload selectively to solid tumors. An important driver of passive targeting is the enhanced permeability and retention (EPR) effect, whi...
Polymeric nanoparticle suspension is a newly developed oil-displacing agent for enhanced oil recovery (EOR) in low-permeability reservoirs. In this work, SiO2/P(MBAAm-co-AM) polymeric nanoparticles were successfully synthesized by a simple distillati...
The hydro-swelling of smectite clay minerals in low-permeability reservoirs further decreases the reservoir permeability and results in low oil recovery. Currently, the traditional chemical anti-swelling agents are widely used, but most of them are o...
Silicate bacteria, capable of decomposing silicate minerals that are widely distributed in oil reservoirs, have never been applied in microbial enhanced oil recovery (MEOR). This study investigated a typical silicate bacterium (Paenibacillus mucilagi...
Polymer-drug conjugates have demonstrated clinical potential in the context of anticancer therapy. However, such promising results have, to date, failed to translate into a marketed product. Polymer-drug conjugates rely on two factors for activity: (...
This study addresses the limitations of traditional chemical flooding in low-permeability reservoirs by developing a nanofluid–surfactant binary flooding system (Has5/iNanoW1.0 binary flooding system) and investigating its microscopic mechanism...
To improve oil recovery significantly in low-mid permeability reservoirs, a novel modified nano-SiO2 hyperbranched copolymer (HPBS), consisting of polyacrylamide as hydrophilic branched chains and modified nano-SiO2 as the core, was synthesized via a...
Background: Previous studies have suggested that electromagnetic pulse (EMP) can induce openings in the blood–brain barrier (BBB). However, the temporal variation and spatial distribution of BBB permeability after EMP radiation are difficult to...
Water flooding in low-permeability, highly heterogeneous reservoirs often causes a rapid increase in water cut and inefficient pressure maintenance because injected water preferentially flows through high-permeability channels. In this study, a field...
Innumerable people worldwide die of cancer every year, although pharmaceutical therapy has actualized many benefits in human health. For background, anti-cancer drug development is difficult due to the multifactorial pathogenesis and complicated path...
The efficiency of carbon utilization and storage within the Pennsylvanian Morrow B sandstone, Farnsworth Unit, Texas, is dependent on three-phase oil, brine, and CO2 flow behavior, as well as spatial distributions of reservoir properties and wettabil...
High-pressure water injection (HPWI) refers to injecting water into the formation under conditions where the injection pressure is higher than or close to the formation fracture pressure. This technique can effectively improve the water absorption ca...
The enhanced permeable groin is a novel eco-friendly and cost-effective technique for bank protection and restoration of meander bends. The behavior of bed deformations due to the distance between the structures has to be studied to design enhanced p...
Hydraulic fracturing for economic production from unconventional reservoirs is subject to many subsurface uncertainties. One such uncertainty is the impact of natural fractures in the vicinity of hydraulic fractures in the reservoir on flow and thus...
In view of current research on the cracking mechanism of high-energy gas on coal, little attention has been paid to imitating the law of explosive blasting and cracks propagation, and the influence of joint on cracks propagation in the process of hig...
Sufficient colonic absorption is necessary for all systemically acting drugs in dosage forms that release the drug in the large intestine. Preclinically, colonic absorption is often investigated using the rat single-pass intestinal perfusion model. T...
Coalbed methane (gas) is a high quality and clean resource, but it also causes disasters in coal mines in China. The low permeability of coal seams is the main reason that developing coalbed methane (CBM) as an energy resource is difficult, so increa...
The traditional geological view holds that overpressure resists mechanical compaction during sedimentary burial, keeping effective stress approximately constant and thereby passively preserving porosity and permeability in deep reservoirs. However, t...
Steam-assisted gravity oil drainage (SAGD flooding) is a cutting-edge technology for the development of oils which is gradually replacing steam huff and puff and is being used more and more widely. Low-permeability interlayers are generally developed...
Heat treatment on shale reservoirs can promote the development of secondary fractures in a matrix on the basis of hydraulic fracturing, forming multi-scale gas–water seepage channels and strengthening the gas desorption. Experimental evidence s...
Developing effective oral formulations for poorly soluble anticancer drugs remains a major pharmaceutical challenge due to the combined limitations of solubility, permeability, and efflux transporter activity. In this work, we investigated the influe...
To solve the problems of high injection pressure and low water injection in an ultra-low-permeability reservoir, nanoemulsion was injected to reduce the surface interfacial tension, change the wettability, and achieve the purpose of depressurization....
The delivery of therapeutics across biological membranes (e.g., mucosal barriers) by avoiding invasive routes (e.g., injection) remains a challenge in the pharmaceutical field. As such, there is the need to discover new compounds that act as drug per...
Permeation enhancers like sodium dodecyl sulfate (SDS) and caprate increase the intestinal permeability of small model peptide compounds, such as enalaprilat (349 Da). However, their effects remain to be investigated for larger low-permeability pepti...
The efficient development of coalbed methane (CBM) faces persistent challenges due to low recovery rates. While CO2 thermal displacement offers a promising approach, the pore–fracture structure (PFC) evolution and gas displacement mechanisms un...
To investigate the influence of hydraulic permeability enhancement on the gas desorption and accumulation characteristics of water-bearing coal bodies and deeply implement hydraulic fracturing measures to prevent and control gas disasters in coal sea...
This study investigates the acid–rock reaction kinetics and their implications for enhancing tight limestone reservoir stimulation through systematic experiments. Using 14 tight limestone cores, we evaluate the dynamic behavior of single-phase...
The development of deep coalbed methane is hindered by the strong heterogeneity of coal mechanical properties and complex hydraulic fracturing behavior. To identify the key factors controlling fracture geometry and permeability enhancement, this stud...
Polymer flooding has achieved considerable success in medium–high permeability reservoirs. However, when it comes to low-permeability reservoirs, polymer flooding suffers from poor injectivity due to the large molecular size of the commonly use...
This invited editorial article aims at reporting progress about the enhanced permeability and retention effect (EPR for short), starting from a recent Special Issue in the Journal of Personalized Medicine (namely, “EPR Effect-Based Tumor Target...
Waterflooding in saline lacustrine carbonate reservoirs frequently induces dissolution of soluble salt minerals, a process that substantially alters pore architecture and transport properties. However, the quantitative relationship between salt disso...
In the Shenhu Area of the South China Sea, although some numerical studies are conducted on the gas production at well SHSC-4, the geomechanical responses have not been taken into account, and the associated impact of permeability enhancement on gas...
In China, sandstone geothermal reservoirs are large in scale and widely distributed, but their exploitation is hindered by low recharge efficiency. In this paper, an unblocking and permeability enhancement technology using a rotary water jet for low...
Tectonic coal seams are characterized by soft, low permeability and high gas outburst. The traditional gas control method is the intensive drilling and extraction in this seam, which is not only large in engineering quantity, high in cost, difficult...
Ultra-low-permeability tight oil reservoirs, including the Chang 6 and Chang 8 formations in the Changqing Oilfield and the Fuyu reservoir in the peripheral Daqing Oilfield, are characterized by poor reservoir properties and limited waterflooding eff...
To solve the bottleneck problem of low deep coal seam permeability and difficult coalbed methane (CBM) mining. Combining hydraulic splitting technology and directional drilling technology, a directional hydraulic splitting enhancement method of deep...
Continental shale oil reservoirs contain multiscale pore–fracture systems with strong heterogeneity and fractal characteristics, which complicate oil mobilization during post-fracturing shut-in imbibition. In this study, shale cores from the LG...
Suberoylanilide hydroxamic acid (SAHA) or vorinostat (VOR) is a potent inhibitor of class I histone deacetylases (HDACs) that is approved for the treatment of cutaneous T-cell lymphoma. However, it has the intrinsic limitations of low water solubilit...
10 October 2023
Green tea extract, rich in polyphenols like catechins, has been reported to have pharmacological benefits in patients with hyperlipidemia. The minimal membrane permeability of green tea limits its use in terms of bioavailability. To improve the perme...
The optimization of membrane permeability is a pivotal approach for mitigating late-stage failures in peptide drug development. By leveraging linker chemical diversity, stapled peptides utilize linker engineering to precisely modulate key physicochem...
The poor aqueous solubility and/or permeability and thereby limited bioavailability largely restricts the pharmaco-therapeutic implications of potent anticancer drugs such as methotrexate (MTX). Furthermore, MTX’s inherently unstable nature mak...
Cement–bentonite cut-off walls are widely used in geoenvironmental engineering such as landfill liners and contaminated site remediation, due to their low permeability and structural stability. However, excessive cement use reduces the swelling...
of 103