EPR Effect-Based Cancer Targeted Therapy: Commemorative Issue in Honor of Professor Hiroshi Maeda
A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".
Deadline for manuscript submissions: closed (10 November 2022) | Viewed by 32015
Special Issue Editor
Interests: nanomedicine; tumor-targeting; EPR effect; carbon monoxide; inflammation; reactive oxygen species
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue of the Journal of Personalized Medicine entitled “EPR Effect-Based Cancer Targeted Therapy” is dedicated to Professor Hiroshi Maeda, the founder of the concept of the EPR effect, on the occasion of his unexpected passing.
Professor Maeda (1938–2021) was one of the most distinguished and influential scientists in the field of tumor targeting and nanomedicine, as well as in the field of reactive oxygen species (ROS) and viral infection. He graduated from Tohoku University, Japan (1962), followed by a master’s degree and PhD at the University of California, Davis (1962–1964), and Tohoku University (1964–1968), respectively. He carried out his postdoc study at the Dana-Farber Cancer Institute, Harvard University (1968–1971), which paved the way to his professorship at Tohoku University (1971–1981) and then Kumamoto University School of Medicine (1981–2004), where he developed the first polymer anticancer drug SMANCS and discovered the EPR effect with his colleague Dr. Matsumura. Now, the EPR effect has been becoming the basic concept of tumor targeting using nanomedicine and a standard for designing nanomedicine. In addition to the EPR effect, he was also the one who first reported that ROS is the major cause of pneumonia in influenza infection and that removal of ROS could effectively improve the progression of the disease, which I believe is a mechanism that could be applied to COVID-19-induced pneumonia. His scientific excellence and integrative personality were internationally recognized with numerous awards, including the Asagawa Award of the Japanese Society for Bacteriology (1995), Princess Takamatsu Cancer Research Fund Prizes (1997), Frey-Werle Award/Commemorative Gold Medal (1998), Life Time Achievement Award of the Royal Society of Pharmacy (2007), Nagai Award of the Japan Society of Drug Delivery System (2011), the Tomizo Yoshida Prize of the Japanese Cancer Association (2011), Thomson Reuters Citation Laureate (2016), Wayne State University Roland T. Lakey Award (2017), and the Order of the Sacred Treasure, Gold Rays with Neck Ribbon, Cabinet Office, Japan (2018).
Professor Maeda was a real scientist and excellent mentor. He developed various anticancer nanomedicines and carried out efforts for clinical application until his last day. Conquering Cancer and helping cancer patients were his lifelong dream, and we strongly believe this dream will become true, and EPR-based nanomedicine will be a solution to cancer.
We invite researchers to submit review articles and original articles for an in-depth understanding of the EPR effect and further exploitation of its effect on human cancer. New strategies for enhancement of the EPR effect using nanomedicine and imaging technology with the help of nanosize fluorogenic agents will be welcome.
Dr. Jun Fang
Guest Editor
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Keywords
- EPR effect
- nanomedicine macromolecular drugs
- tumor delivery
- tumor targeting
- tumor imaging
- tumor selectivity
- tumor vasculature
- drug retention
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