Fungi are an important group of microorganisms that play crucial roles in a variety of ecological and biotechnological processes. Fungi depend on intracellular protein trafficking, which involves moving proteins from their site of synthesis to the fi...
Much progress has been made in determining that paternal environmental exposures can remodel their spermatozoa small noncoding RNAs (sncRANs) and, in turn, affect the phenotypes of their offspring. Studies have shown that changes in the spermatozoa s...
Using density functional theory (DFT), we performed first-principles calculations of the electrical conductivity, optical absorption, and reflectivity for the 2D carbides SnC and NbC. We calculated the electronic energy band structure of the material...
Excessive adiposity caused by high-fat diets (HFDs) is associated with testicular metabolic and functional abnormalities up to grand-offspring, but the mechanisms of this epigenetic inheritance are unclear. Here we describe an association of sperm sm...
Advanced paternal age at fertilization is a risk factor for multiple disorders in offspring and may be linked to age-related epigenetic changes in the father’s sperm. An understanding of aging-related epigenetic changes in sperm and environment...
Diagnosis of neurodegenerative disease (NDD) is complex, therefore simpler, less invasive, more accurate biomarkers are needed. small non-coding RNA (sncRNA) dysregulates in NDDs and sncRNA signatures have been explored for the diagnosis of NDDs, how...
This study aims to explore the potential inhibition effects of staurosporine isolated from a Streptomyces sp. SNC087 strain obtained from seawater on nasal polyps. Staurosporine possesses antimicrobial and antihypertensive activities. This research f...
PSA testing plays an important role in the diagnostic workup of prostate cancer; despite this, its cancer specificity is a well-recognised limitation. Consequently, more reliable, non-invasive diagnostic tools that are capable of improving specificit...
Small non-coding RNAs (sncRNAs) have garnered considerable attention in recent years, following accumulating evidence of their critical roles in many cellular processes. Among sncRNAs, microRNAs (miRNAs) and their isoforms (isomiRs), tRNA-derived fra...
6 July 2019
Observations of ocean pollutants are usually spatiotemporally dispersive, while it is of great importance to obtain continuous distribution of ocean pollutants in a certain area. In this paper, a dynamically constrained interpolated methodology (DCIM...
Plants utilize plasma membrane localized receptors like kinases (RLKs) or receptor-like proteins (RLPs) to recognize pathogens and activate pattern-triggered immunity (PTI) responses. A gain-of-function mutation in the Arabidopsis RLP SNC2 (SUPPRESSO...
Emerging small non-coding RNAs (sncRNAs), including tRNA-derived small RNAs (tsRNAs) and rRNA-derived small RNAs (rsRNAs), are critical in various biological processes, such as neurological diseases. Traditional sncRNA-sequencing (seq) protocols ofte...
Deregulation of small non-coding RNAs (sncRNAs) has been associated with the onset of metastasis. We evaluated the expression of sncRNAs in patients with early-stage breast cancer, performing RNA sequencing in 60 patients for whom tumor and sentinel...
Starch-based nanocomposites (SNCs) are at the forefront of innovations in food science, offering unparalleled opportunities for enhancing the stability, bioactivity, and overall functionality of food systems. This review delves into the potential of...
Respiratory syncytial virus (RSV) causes acute lower respiratory tract infection in infants, immunocompromised individuals and the elderly. As the only current specific treatment options for RSV are monoclonal antibodies, there is a need for efficaci...
Dopamine is likely the most studied modulatory neurotransmitter, in great part due to characteristic motor deficits in Parkinson’s disease that arise after the degeneration of the dopaminergic neurons in the substantia nigra pars compacta (SNc). The...
The present work seeks to determine the impact of weight percentage (wt%) of grafted starch nanocrystals (g-SNCs) on the oxygen and water vapour permeability of poly (lactic acid), PLA. Changes in the oxygen and water vapour permeability of PLA due t...
This narrative review explores the interconnected relationship between quality of life (QoL) and satisfaction with nursing care (SNC) among cancer patients, recognizing that cancer’s burden extends beyond survival and significantly affects phys...
Human adenoviruses (HAdVs) are common pathogens causing a variety of respiratory, ocular and gastrointestinal diseases. To accomplish their efficient replication, HAdVs take an advantage of viral small non-coding RNAs (sncRNAs), which have multiple r...
The study of liquid biopsy with plasma samples is being conducted to identify biomarkers for clinical use. Exosomes, containing nucleic acids and metabolites, have emerged as possible sources for biomarkers. To evaluate the effectiveness of exosomes...
We performed next-generation sequencing (NGS) on RNA from 19 paired leiomyoma (Lyo) and myometrium (Myo) specimens, stratified by race/ethnicity (White: n = 7; Black: n = 12) and mediator complex subunit 12 (MED12) mutation status (mutated: n = 10; n...
In the last years it has become increasingly clear that the mammalian transcriptome is highly complex and includes a large number of small non-coding RNAs (sncRNAs) and long noncoding RNAs (lncRNAs). Here we review the biogenesis pathways of the thre...
We recently developed a series of nalfurafine analogs (TK10, TK33, and TK35) that may serve as non-addictive candidate analgesics. These compounds are mixed-action agonists at the kappa and delta opioid receptors (KOR and DOR, respectively) and produ...
Advances in understanding disease pathogenesis correlates to modifications in gene expression within different tissues and organ systems. In depth knowledge about the dysregulation of gene expression profiles is fundamental to fully uncover mechanism...
Background: Accurate estimation of the postmortem interval (PMI), the time elapsed between death and body discovery, is a critical challenge in forensic science due to the complex interplay of factors affecting decomposition. Traditional methods base...
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb), with 10.4 million new cases per year reported in the human population. Recent studies on the Mtb transcriptome have revealed the abundance of noncoding RNAs expres...
Maternal diet during gestation and lactation affects the development of skeletal muscles in offspring and determines muscle health in later life. In this paper, we describe the association between maternal low protein diet-induced changes in offsprin...
Bivalve mollusks thrive in environments rich in microorganisms, such as estuarine and coastal waters, and they tend to accumulate various particles, including viruses. However, the current knowledge on mollusk viruses is mainly centered on few pathog...
In complex battlefield environments, flying ad-hoc network (FANET) faces challenges in manually extracting communication interference signal features, a low recognition rate in strong noise environments, and an inability to recognize unknown interfer...
Lubricant additive plays an important role in reducing the friction and wear for base oil. MAX phase ceramics may have superior advantages for additive application due to their unique nanolayered structure. In this paper, Ti2SnC ceramic is prepared b...
Despite the improvements in biotechnological approaches and the selection of controlled ovarian hyperstimulation protocols, the resulting pregnancy rate from in vitro fertilization (IVF) protocols still does not exceed 30–40%. In this connectio...
Reproductive dysfunction and urogenital malignancies represent a serious health concern in men. This is in part as a result of the absence of reliable non-invasive tests of diagnosis/prognosis. Optimizing diagnosis and predicting the patient’s...
In eukaryotes, the retromer complex is critical for the transport of cargo proteins from endosomes to the trans-Golgi network (TGN). Despite its importance, there is a lack of research on the retromer-mediated transport of cargo proteins regulating t...
Tin-based nanocomposite materials embedded in carbon frameworks can be used as effective negative electrode materials for lithium-ion batteries (LIBs), owing to their high theoretical capacities with stable cycle performance. In this work, a low-cost...
Layered ternary Ti2SnC carbides have attracted significant attention because of their advantage as a M2AX phase to bridge the gap between properties of metals and ceramics. In this study, Ti2SnC materials were synthesized by two different methods&mda...
Here, we link approved and emerging nucleic acid-based therapies with the expanding universe of small non-coding RNAs (sncRNAs) and the innate immune responses that sense oligonucleotides taken up into endosomes. The Toll-like receptors (TLRs) 3, 7,...
Beyond their central role in protein synthesis, transfer RNAs (tRNAs) have many other crucial functions. This includes various roles in the regulation of gene expression, stress responses, metabolic processes and priming reverse transcription. In th...
This study explored the effect of incorporating cellulose and starch nanoparticles, obtained from the Commelina coelestis Willd plant, on the physical and chemical properties of starch-based films derived from the same plant. Additionally, the synerg...
Small non-coding RNAs (sncRNAs), particularly microRNAs (miRNAs), play an important role in transcriptome regulation by binding to mRNAs and post-transcriptionally inhibiting protein production. This regulation occurs in both physiological and pathol...
The use of safety helmets in industrial settings is crucial for preventing head injuries. However, traditional helmet detection methods often struggle with complex and dynamic environments. To address this challenge, we propose YOLOv8s-SNC, an improv...
We report on investigating the structural and electronic properties of semiconducting and insulating layers produced in a process resembling percolation in a unique cold plasma fabrication method (plasma-enhanced chemical vapor deposition—PECVD). Amo...
Small noncoding RNAs (sncRNAs) are key regulators of the majority of human reproduction events. Understanding their function in the context of gametogenesis and embryogenesis will allow insight into the possible causes of in vitro fertilization (IVF)...
The incorporation of MAX phase interface layers into silicon carbide (SiC) composites has been shown to significantly enhance mechanical properties, particularly under irradiation conditions. However, conventional Ti-based MAX phases suffer from ther...
This work prepared SnO2 coatings on 304 stainless steel via the sol–gel and dip-coating techniques, using tin (II) chloride (SnCl2) and tin (II) oxalate (SnC2O4) as precursors. The crystal structure analyzed by X-ray Diffraction (XRD) confirmed...
Controlled degradation of genomic DNA is a hallmark of programmed cell death (PCD) in plants and animals. In plants, nucleic acid degradation during PCD enables nutrient redistribution. S1/P1 nucleases are established participants; however, the staph...
In this study, low-temperature synthesis of a Nb2SnC non-MAX phase was carried out via solid-state reaction, and a novel approach was introduced to synthesize 2D Nb2CTx MXenes through selective etching of Sn from Nb2SnC using mild phosphoric acid. Ou...
The medical sciences are facing a major problem with the auto-detection of disease due to the fast growth in population density. Intelligent systems assist medical professionals in early disease detection and also help to provide consistent treatment...
Purpose: Recently, a novel approach to apicoectomy has emerged, involving the use of a hollow trephine with a surgical guide. This innovative technique creates a semicircular section, in contrast to the conventional straight cut (with a bur). The sem...
This paper presents an interpretable, spiking neural classifier (IpT-SNC) with time-varying weights. IpT-SNC uses a two-layered spiking neural network (SNN) architecture in which weights of synapses are modeled using amplitude-modulated, time-varying...
This study investigated the formation and molecular interaction mechanism of chestnut starch nanocrystal (SNC)/macadamia protein isolate (MPI) complexes and their application in edible oil-in-water Pickering emulsion (PE). SNC/MPI complexes were char...
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