Genetic and Molecular Markers in Prostate Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 19 February 2026 | Viewed by 8
Special Issue Editor
Special Issue Information
Dear Colleagues,
Prostate cancer (PCa) is the second most commonly diagnosed malignancy in men worldwide and affects one in nine men in the United States. While localized PCa is often managed effectively with surgery, radiation, or active surveillance, metastatic disease remains lethal, with a five-year survival rate of ~31%. Because prostate tumors rely on androgen signaling for growth, androgen deprivation therapy (ADT) is the mainstay treatment for advanced disease. However, many tumors progress to metastatic castration-resistant prostate cancer (mCRPC), where androgen receptor pathway inhibitors (ARPIs) are used. Unfortunately, resistance to ARPIs typically develops within a year, emphasizing the urgent need for new strategies.
Recent advances—including next-generation AR inhibitors, PARP inhibitors, radiopharmaceuticals, and immunotherapies—offer promising avenues. Yet, treatment resistance, limited predictive biomarkers, and uncertainty around optimal therapy sequencing remain significant challenges.
This Special Issue of the International Journal of Molecular Sciences will focus on the genetic and molecular markers driving PCa development, progression, and therapeutic response. We welcome original research, reviews, and translational or clinical studies that
- Identify diagnostic, prognostic, and predictive biomarkers;
- Investigate resistance mechanisms to ADT and ARPIs;
- Explore novel genetic targets for therapy;
- Advance precision oncology through personalized approaches.
Our goal is to promote insights that improve clinical outcomes in prostate cancer.
Dr. Thaidy Moreno-Rodriguez
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- prostate cancer
- genetic markers
- androgen receptor signaling
- molecular biomarkers
- therapy resistance mechanisms
- liquid biopsy
- precision oncology
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
