Cell cycle progression is highly regulated by modulating the phosphorylation status of the retinoblastoma protein (pRB) and the other two members of the RB family, p107 and p130. This process is controlled by a balance in the action of kinases, such...
As part of our ongoing studies on the potential pathophysiological role of serine/threonine phosphatases (PP) in the mammalian heart, we have generated transgenic mice with cardiac muscle cell-specific overexpression of PP2Acα (PP2A) and PP5 (PP5). F...
Bud endodormancy is an important, complex process subject to both genetic and epigenetic control, the mechanism of which is still unclear. The endogenous hormone abscisic acid (ABA) and its signaling pathway play important roles in the endodormancy p...
Protein phosphatase 2Cs (PP2Cs) are members of the serine/threonine phosphatase family that play pivotal roles in regulating plant development and responses to environmental stresses. However, comprehensive genome-wide studies of the PP2C gene family...
By considering that the α relaxation related to the glass to rubber transition (obtained by dynamic mechanical analysis) of isotactic polypropylene (iPP) can be identified with the thermal history of the material (and so, with the processing st...
Male fertility relies on the ability of spermatozoa to fertilize the egg in the female reproductive tract (FRT). Spermatozoa acquire activated motility during epididymal maturation; however, to be capable of fertilization, they must achieve hyperacti...
Fruit softening, an irreversible ripening process that causes postharvest losses, is mainly attributed to cell wall disassembly, rendering cell-wall-modifying genes critical targets for genetic improvement. However, the molecular mechanism by which e...
In this paper, we obtain upper bounds on the minimum distance for turbo codes using fourth degree permutation polynomial (4-PP) interleavers of a specific interleaver length and classical turbo codes of nominal 1/3 coding rate, with two recursive sys...
Protein phosphatase 2A (PP2A) is a highly complex heterotrimeric Ser/Thr phosphatase that regulates many cellular processes. PP2A is dysregulated in several human diseases, including oncological pathology; interestingly, PP2A appears to be essential...
Protein phosphatase 2A (PP2A) is a ubiquitous serine/threonine phosphatase implicated in a wide variety of regulatory cellular functions. PP2A is abundant in the mammalian nervous system, and dysregulation of its cellular functions is associated with...
Fruit ripening and softening are important physiological processes in fruit quality formation, and auxin is involved in regulating the ripening and softening process in peach fruit. Little research has been reported on the role of Aux/IAA (auxin/indo...
This work deals with the changes of the glass transition temperature (Tg) of the polymer in polypropylene/mica composites due to the combined and synergistic effect of the reinforcement and the interfacial modifier. In our case, we studied the effect...
Protein Phosphatase 2A (PP2A) is a major serine/threonine phosphatase in cells. It consists of a catalytic subunit (C), a structural subunit (A), and a regulatory/variable B-type subunit. PP2A has a critical role to play in homeostasis where its pre...
Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII), a multifunctional serine (Ser)/threonine (Thr) protein kinase, regulates diverse activities related to Ca2+-mediated neuronal plasticity in the brain, including synaptic activity and gene ex...
Two-photon polymerization (2PP) is revolutionizing micro- and nanoscale manufacturing by enabling true 3D fabrication with feature sizes far below the diffraction limit—capabilities that traditional lithography cannot match. By using ultrafast...
Background/Objectives: Therapy-induced senescence (TIS), while initially growth-suppressive, may promote tumor recurrence through the persistence of senescent cells and the senescence-associated secretory phenotype (SASP). Topotecan, a topoisomerase...
Nanocomposites based on isotactic polypropylene (iPP) and mesoporous silica particles of either MCM-41 or SBA-15 were prepared by melt extrusion. The effect of the silica incorporated into an iPP matrix was firstly detected in the degradation behavio...
We motivate a ‘rooted’ PP shell analysis of Arabic prepositional phrases, which takes into account the prepositional dual life, as a lexical root item and as a vocabulary word, projecting a lexical √P headed by the P root, and a fun...
Peach (Prunus persica) production and the northward expansion of its cultivation boundaries are severely constrained by recurrent extreme climatic events. Based on time-series transcriptomic analysis of two independent parallel treatments (cold stres...
Volatile organic compounds (VOCs) from polypropylene (PP) seriously restricts the application of PP in an automotive field. Herein, the traceability of VOCs from PP resins during manufacturing process and accelerated photoaging degradation was clarif...
Background: Protein phosphatase 2Cs (PP2Cs) constitutes the largest phosphatase family in plants, playing a pivotal role in signal transduction. Within this family, the PP2C.D subfamily exerts significant influence on cell elongation and stress adapt...
Background: Protein phosphatase 2A (PP2A) is a conserved serine/threonine phosphatase that plays crucial roles in stress responses, yet its function in strawberry (Fragaria spp.) remains largely uncharacterized. This study aimed to characterize the P...
This work analyzes the thermal degradation and mechanical properties of iron (Fe)-containing MgAl layered double hydroxide (LDH)-based polypropylene (PP) nanocomposite. Ternary metal (MgFeAl) LDHs were prepared using the urea hydrolysis method, and F...
Type 1 protein phosphatases (PP1s) are crucial in various plant cellular processes. Their function is controlled by regulators known as PP1-interacting proteins (PIPs), often intrinsically disordered, such as Inhibitor 2 (I2), conserved across kingdo...
Phytophthora parasitica is a devastating oomycete pathogen that causes significant crop losses worldwide. Identifying master regulators of its virulence is crucial for the development of novel control strategies. Here, we demonstrate that the conserv...
Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) using the SEXTANT® system (Medtronic) featured the first generation of commercially available percutaneous pedicle screw (PPS) system in 2001. The innovative system has since be...
Marek’s disease (MD) is an immunosuppressive and highly contagious lymphoproliferative disease caused by Marek’s disease virus (MDV) in poultry. Lymphoblastoid cell lines (LCLs) generated ex vivo from MD lymphomas are considered excellent models to s...
Low temperatures are a major environmental factor limiting the growth and productivity of peaches (Prunuspersica). U-box E3 ubiquitin ligases (PUBs) are known to play a role in plant responses to abiotic stresses; however, their role in cold toleranc...
The MYC transcription factor is one of the best characterized PP2A substrates. Deregulation of the MYC oncogene, along with inactivation of PP2A, are two frequent events in cancer. Both proteins are essential regulators of cell proliferation, apoptos...
Dwarfing rootstocks enhance planting density, lower tree height, and reduce both labor in peach production. Cerasus humilis is distinguished by its dwarf stature, rapid growth, and robust fruiting capabilities, presenting substantial potential for fu...
Reactive oxygen species (ROS) carry out vital functions in determining appropriate stress reactions in plants, but the molecular mechanisms underlying the sensing, signaling and response to ROS as signaling molecules are not yet fully understood. Rec...
Protein phosphorylation is a post-translational modification essential for the control of the activity of most enzymes in the cell. This protein modification results from a fine-tuned balance between kinases and phosphatases. PP2A is one of the major...
Polypropylene (PP) and polyvinylidene fluoride (PVDF) polymer materials have been widely used because PP has excellent piezoelectricity and PVDF has a robust tensile strength. However, few studies have been reported about PP/PVDF blends, and the main...
Protein phosphatase 2A (PP2A) is a highly conserved heterotrimeric enzyme complex present in all eukaryotic cells, consisting of a scaffolding A subunit, a catalytic C subunit, and a regulatory B subunit. The A and C subunits form the core enzyme, wh...
The excessive use of conventional antibiotics in aquaculture has created significant challenges, making it essential to explore and develop effective alternatives. Antimicrobial peptides (AMPs) have gained attention as potential therapeutic agents ow...
Background: Protein Phosphatase 2C (PP2C), a conserved family in plants, plays a crucial role in ABA and MAPK signaling pathways. Its functional diversity provides key mechanisms for plants’ adaptation to environmental changes. However, researc...
Auxin’s role in the post-ripening of peaches is widely recognized as important. However, little is known about the processes by which auxin regulates fruit post-ripening. As one of the early auxin-responsive genes, it is critical to understand...
We explored the composition and roles of the protein phosphatase 2C (PP2C) family in Paulownia fortunei. The genome P. fortunei harbored 91 PfPP2C genes, encoding proteins with 120–1107 amino acids (molecular weight range, 13.51–124.81 kD...
Continuous cropping obstacles (CCOs) lead to a decline in yield and quality under repeated cultivation in the same farmland. Notably, CCOs caused by fusarium wilt, autotoxicity, or imbalance in rhizosphere microbial communities reduce the productivit...
Protein phosphatase 2A (PP2A) is a tumor suppressor complex that has recently been reported as a novel and highly relevant molecular target in prostate cancer (PCa). However, its potential therapeutic value remains to be fully clarified. We treated P...
Long glass fiber-reinforced polypropylene (LGFR-PP) composite structures with stiffeners are important substitutes for metal parts for vehicle lightweighting; a good understanding of the buckling characteristics of LGFR-PP stiffeners would provide an...
Pleurotus pulmonarius is a high-value, commercially cultivated edible fungus whose primordium formation is a critical phase for yield and commercial value. To better understand the developmental processes of P. pulmonarius, samples from four key deve...
Styrene (St) was used as comonomer and glycidyl methacrylate (GMA) as grafting monomer to prepare SEBS-g-(GMA-co-St) graft copolymers via melt grafting. Then, the graft copolymers were employed as a compatibilizer for melt blending polypropylene (PP)...
A new approach to the creation of polypropylene (PP) based foaming materials was developed using food grade foaming agents that were coated on the PP pellets. More specifically, sodium bicarbonate and organic acids were used to coat PP pellets using...
Ribosomally synthesized and post-translationally modified peptides (RiPPs) represent a significant potential for novel therapeutic applications because of their bioactive properties, stability, and specificity. RiPPs are synthesized on ribosomes, fol...
Polypropylene (PP)/acrylonitrile butadiene rubber (NBR) composite plates reinforced with halloysite nanotubes (HNTs) were manufactured in the presence of dual compatibilizers: PP-grafted maleic anhydride (PP-g-MA) and styrene ethylene butylene styren...
Protein serine/threonine phosphatase 2A (PP2A) regulates diverse cellular processes via the formation of ~100 heterotrimeric holoenzymes. However, a scarcity of knowledge on substrate recognition by various PP2A holoenzymes has greatly prevented the...
As the core components of abscisic acid (ABA) signal pathway, Clade A PP2C (PP2C-A) phosphatases in ABA-dependent stress responses have been well studied in Arabidopsis. However, the roles and natural variations of maize PP2C-A in stress responses re...
Electrospinning (e-spinning) is an emerging technique to prepare ultrafine fibers. Polyphenylene sulfide (PPS) is a high-performance resin which does not dissolve in any solvent at room temperature. Commercial PPS fibers are produced mainly by meltbl...
This work presents an experimental investigation on the seismic performance of bridge piers constructed with polypropylene fiber reinforced engineered cementitious composite (PP-ECC) at potential plastic hinge regions. Eight solid square bridge piers...
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