The basic helix-loop-helix (bHLH) transcription factor family is one of the largest transcription factor gene families in Arabidopsis thaliana, and contains a bHLH motif that is highly conserved throughout eukaryotic organisms. Members of this family...
In this paper we study electromagnetic forces induced on DNA and DNA-like helices by external electromagnetic waves. We consider simultaneously occurring forces and torques, interconnected and acting along the double helix axis. Since the DNA molecul...
This study invents a Triple Helix of university-public-government for sustainable development, as a complement to the Triple Helix of university-industry-government for innovation. Twinning the two retains the dynamic properties of a tertius gaudens...
As one of the most interesting naturally-occurring geometries, micro-helical structures have attracted attention due to their potential applications in fabricating biomedical and microelectronic devices. Conventional processing techniques for manufac...
The inhibitor of DNA binding and cell differentiation 2 (Id2) is a helix-loop-helix (HLH) protein that acts as negative dominant regulator of basic-HLH transcription factors during development and in cancer. The structural properties of Id2 have been...
The first event of differentiation and morphogenesis in the optic vesicle (OV) is specification of the neural retina (NR) and retinal pigment epithelium (RPE), separating the inner and outer layers of the optic cup, respectively. Here, we focus on a...
The aim of the article is to study the forces arising in a conductive DNA-like double helix in the field of a microwave electromagnetic wave. These forces must be considered for both actual DNA molecules and double DNA-like helices that serve as comp...
The introduction of α-helical structure with a specific helix–helix interaction into an amphipathic molecule enables the determination of the molecular packing in the assembly and the morphological control of peptide assemblies. We previously reporte...
Through more than 40 years of reading, thinking, searching, and experimentation, we have found that the double helix model carries some defects or incorrect information. Evidence gleaned from the literature clearly indicates that the two strands of D...
Here we propose the use of twist and glide symmetries to increase the equivalent refractive index in a helical guiding structure. Twist- and glide-symmetrical distributions are created with corrugations placed at both sides of a helical strip. Combin...
The Triple Helix concept of innovation systems holds that consensus space among industry, government and university is required to bring together their competences to achieve enhanced economic and social development on a systemic scale. In line with...
The basic helix-loop-helix (bHLH) transcription factors in insects play essential roles in multiple developmental processes including neurogenesis, sterol metabolism, circadian rhythms, organogenesis and formation of olfactory sensory neurons. The id...
α-Helices often recognize their target proteins at protein–protein interfaces through more than one recognition face. This review describes the state-of-the-art in the design of non-peptidic α-helix mimetics that reproduce functionality from multiple...
The article evaluates the relationships between the individual actors of the Quintuple Helix model and sustainability across EU countries. The model is based on the idea that innovation arises from the collaboration of five key subsystems: government...
Dendrobium officinale Kimura et Migo is of great importance as a traditional Chinese herb due to its abundant metabolites. The family of basic helix-loop-helix (bHLH) transcription factors widely exists in plants and plays an essential role in plant...
Riboswitches are highly structured RNA regulators of gene expression. Although found in all three domains of life, they are particularly abundant and widespread in bacteria, including many human pathogens, thus making them an attractive target for an...
Eric Lord has observed: “In nature, helical structures arise when identical structural subunits combine sequentially, the orientational and translational relation between each unit and its predecessor remaining constant.” This paper prove...
Scorpion venom contains various bioactive peptides, many of which exhibit insecticidal activity. The majority of these peptides have a cystine-stabilized α-helix/β-sheet (CSαβ) motif. In addition to these peptides, scorpion veno...
Given the uncertain outlook caused by COVID-19, it is important to carry out a review of the conditions in which the collective enterprises are influenced by the four helix model, specifically those dedicated to the sector most affected by the pandem...
The Boerdijk–Coxeter helix is a helical structure of tetrahedra which possesses no non-trivial translational or rotational symmetries. In this document, we develop a procedure by which this structure is modified to obtain both translational and...
Peroxisome proliferator-activated receptor gamma (PPARγ) has recently been revealed to regulate tumor microenvironments. In particular, genetic alterations of PPARγ found in various cancers have been reported to play important roles in tu...
Helix-membrane interactions are key to membrane deformation and play significant biological roles. However, systematic studies on the mechanisms behind these interactions are limited. This study uses a continuum membrane model to investigate how shal...
A phenylacetylene containing the l-valine ethyl ester pendant (PAA-Val) was synthesized and polymerized by an organorhodium catalyst (Rh(nbd)BPh4) to produce the corresponding one-handed helical cis-poly(phenylacetylene) (PPAA-Val). PPAA-Val showed a...
This paper proposes a novel method for feeding a half-turn quadrifilar helix antenna (QHA) operating in backfire mode. A self-phasing and self-supporting antenna is obtained using a specific method demonstrated numerically. Four straight parallel wir...
The prolonged duration of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has resulted in the continuous emergence of variants of concern (VOC, e.g., Omicron) and variants of interest (VOI, e.g., Lambda). These variants have...
Understanding the relationship between environmental, social, and governance (ESG) considerations and digital transformation is relevant to sustainable development in the European Union (EU). This study maps the inter-relationships among the ESG prin...
Waveguide optical properties of a cholesteric liquid crystal (CLC) layer with a deformed lying helix (DLH) have been studied by numerical simulations using the finite difference time domain method. The DLH structure, when the helix’s axis is or...
The smart cities policy approach has been intensively implemented in European cities under the Horizon 2020 programme. However, these implementations not only reduce the interdependencies among stakeholders to technocratic Public-Private-Partnership...
We present an analysis of α-helix folding in the coarse-grained coordinate of number of formed helical hydrogen bonds (NHBs) for four alanine peptides (ALA)n, with n = 5, 8, 15, and 21 residues. Starting with multi-microsecond all-atom molecula...
To investigate the effect of C-terminal helix on the stability of the FF domain, we studied the native domain FF3-71 from human HYPA/FBP11 and the truncated version FF3-60 with C-terminal helix being deleted by molecular dynamics simulations with GRO...
This study investigates the axial performance of continuous helix screw piles compared to helical piles through full-scale compression and tension load testing in layered soils. Twenty-three piles were installed and tested. The results demonstrate th...
The establishment of broad-based networks, such as the Triple Helix, for innovation and sustainability is sufficiently corroborated. In this work we suggest that the information received from the Triple Helix has a significant and different impact on...
The objective of this study was to assess the transverse maxillary skeletal, dental, and nasal effects of quad-helix treatment (slow maxillary expansion) in comparison to an untreated group. This study was performed on 24 patients. Before and after t...
In the α/β hydrolases superfamily, the extra module modulated enzymatic activity, substrate specificity, and stability. The functional role of N-terminal extensional long α-helix (Ala2-Glu29, designated as NEL-helix) acting as the ex...
Orientation transitions in a cholesteric liquid crystal (CLC) layer with negative dielectric anisotropy, under the influence of a non-uniform spatially periodic electric field created using a planar system of interdigitated electrodes, were studied e...
Triple helix formation of procollagen occurs in the endoplasmic reticulum (ER) where the single-stranded α-chains of procollagen undergo extensive post-translational modifications. The modifications include prolyl 4- and 3-hydroxylations, lysyl...
Digitization and innovation supported by various innovation systems have become key factors in the sustainable development of companies, countries (including UE countries), and the economy as a whole. The primary objective of this study is to explore...
Estrogens play critical roles in embryonic development, gonadal sex differentiation, behavior, and reproduction in vertebrates and in several human cancers. Estrogens are synthesized from testosterone and androstenedione by the endoplasmic reticulum...
The winged helix superfamily comprises a large number of structurally related nucleic acid-binding proteins. While these proteins are often shown to bind dsDNA, few are known to bind ssDNA. Here, we report the identification and characterization of S...
Troponin C (TnC) is the Ca2+-sensing subunit of troponin that is responsible for activating thin filaments in striated muscle, and, in turn, for regulating the systolic and diastolic contractile function of cardiac muscle. The secondary structure of...
The European defense industry is undergoing profound upheavals, and traditional innovation models may no longer be adequate. For this reason, further investigation is needed to know if the triple helix (TH) is suitable for one of the most influential...
In-plane electro-optical switching (IPS) is a natural feature of a conventional planar-aligned display cell based on the deformed helix ferroelectric liquid crystal effect (DHFLC-effect) with a sub-wavelength helix pitch, if the tilt angle is close t...
Hemocyanins are oxygen-transporting glycoproteins in the hemolymph of arthropods and mollusks that attract scientific interest with their diverse biological activities and potential applications in pharmacy and medicine. The aim of the present study...
RNA triple helices are relatively understudied, including their interactions with small molecules. In this study, we evaluated eight previously reported triplex-binding molecules (TBMs) for their functional effects on the premature and mature MALAT1...
Positive-strand RNA viruses universally remodel host intracellular membranes to form membrane-bound viral replication complexes, where viral offspring RNAs are synthesized. In the majority of cases, viral replication proteins are targeted to and play...
Hedera helix L. is known for its therapeutic properties, such as analgesic, anti-inflammatory, expectorant activity. It is currently known that the characteristic therapeutic effects of ivy extracts are induced by phytocompunds, such as: saponins (he...
Surface modification is used to extend the life of implants. To increase the corrosion resistance and improve the biocompatibility of metal implant materials, oxidation of the Ti-13Nb-13Zr titanium alloy was used. The samples used for the research ha...
Mollusks are unique animals with a relatively simple central nervous system (CNS) containing giant neurons with identified functions. With such simple CNS, mollusks yet display sufficiently complex behavior, thus ideal for various studies of behavior...
The helix geometry model of 3D braided composites has been presented, which truly reflects the braided manner and coincides with the actual configuration of the braided composites. The longitudinal tensile stress-strain relationships and the strength...
The effects of proline co-solvent on helix folding are explored through the single discrete coordinate of the number of helical hydrogen bonds. The analysis is based on multi-microsecond length molecular dynamics simulations of alanine-based helix-fo...
of 58