Special Issue "Chromatographic Separation of Enantiomers: Commemorative Issue in Honor of Professor Stig Allenmark on the Occasion of His 80th Birthday"
Deadline for manuscript submissions: closed (15 October 2016).
Interests: chiral separation; chiral recognition; chiral HPLC; optically active polymers; asymmetric polymerization
In the past three decades, separation of enantiomers by chromatographic methods, including high-performance liquid chromatography (HPLC), Supercritical Fluid Chromatography (SFC), simulated moving bed (SMB), capillary electrokinetic chromatography (CEC), thin layer chromatography (TLC), and gas chromatography (GC), has significantly advanced, and a variety of chiral stationary phases (CSP) for these methods have been developed and commercialized. Many chiral compounds can be resolved at least by one of these methods, and the determination of chiral purity has often been performed by these methods. A large-scale separation is also realized by HPLC, SFC, and SMB. However, there still remain many unsolved problems in this field. For instance, rational design for a suitable CSP for a chiral compound is not realized, selection of the best chiral column is not easy, and prediction of elution order of enantiomers is usually difficult.
Professor Stig Allenmark (born in 1936) is Emeritus Professor at Göteborg University since 2001 and has been working at the Department of Organic Chemistry since 1992. His main research interest during the last decades has been within the field of enantioselectivity by chiral discrimination and its use in separation science, particularly in chromatography. His contribution to the advance in chromatographic chiral separation is remarkable as described below. He has published a book on this subject (Chromatographic Enantioseparation, Horwood/Wiley, Chichester/New York 1988; 2nd ed. 1991), which was very well received by the scientific community. In 1982–1983 he was the first to experimentally demonstrate the ability of a common protein (BSA) to discriminate between enantiomers of a variety of chiral organic compounds and that this could be exploited in liquid chromatography by the use of BSA immobilized to silica particles. His research in this field has led to patents and two commercial products. Later, his research interest became focused on studies of kinetic resolution and enzyme stereochemistry by means of chiral chromatographic techniques combined with NMR and chiroptical methods. He has been editorial board member of five international scientific journals, has been a member of the international scientific committees of some of the annual International Symposia on Chiral Discrimination, and was selected by the Royal Academy of Sciences as organizer of a EuCheMS conference on "Mechanisms of Chiral Recognition in Chromatography and the Design of Chiral Phase Systems" held in Kungälv, Sweden in 1995. He has also supported this journal, as an Editorial Board Member, for many years.
The journal is pleased to be publishing a commemorative issue in honor of Professor Stig Allenmark for his outstanding contributions on “Chromatographic Separation of Enantiomers” on the occasion of his 80th birthday in 2016.
This special issue of Molecules welcomes submission of unpublished manuscripts of original work or reviews on “Chromatographic Separation of Enantiomers”. We plan to receive submissions from January to 15 October 2016.
Prof. Yoshio Okamoto
Manuscript Submission Information
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- chiral separation
- chiral recognition
- chiral stationary phases
- enantiomeric purity
- preparative separation
- high-throughput analysis
- membranes for chiral separation