Next Article in Journal
The Verhulst-Like Equations: Integrable OΔE and ODE with Chaotic Behavior
Previous Article in Journal
Second-Order Sliding Mode Formation Control of Multiple Robots by Extreme Learning Machine
Open AccessArticle

Evidence Falsifying the Double Helix Model

UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
Symmetry 2019, 11(12), 1445; https://doi.org/10.3390/sym11121445
Received: 15 October 2019 / Revised: 12 November 2019 / Accepted: 14 November 2019 / Published: 25 November 2019
Through more than 40 years of reading, thinking, searching, and experimentation, we have found that the double helix model carries some defects or incorrect information. Evidence gleaned from the literature clearly indicates that the two strands of DNA are coiled ambidextrously, rather than plectonemically. It is likely that the linking number of native chromosomal Escherichia coli (E. coli) DNA is less than 960. Presently, a clear voice is necessary to break the ice formed from decades of misleading media, questionable textbooks, and expediency. For the sake of science, we are responsible and willing to share our hard-earned knowledge, experience, and knack with the public. A promising research plan is provided for the additional falsification of the right-handed double helix model. It would be a precision hit at the Achilles’ heel of the double helix model. An appropriate conceptual shift will hopefully lead to new knowledge on the secondary structure of DNA and improve understanding of its biological functions. View Full-Text
Keywords: linking number; topoisomerase; left-handed DNA; positive supercoiling; super helical index; ambidextrous double helix linking number; topoisomerase; left-handed DNA; positive supercoiling; super helical index; ambidextrous double helix
Show Figures

Figure 1

MDPI and ACS Style

Xu, Y.C. Evidence Falsifying the Double Helix Model. Symmetry 2019, 11, 1445.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop