Multi-Facial, Non-Peptidic α-Helix Mimetics

Lanning, Maryanna E.; Fletcher, Steven

doi:10.3390/biology4030540

Open AccessReview

Multi-Facial, Non-Peptidic α-Helix Mimetics

by

Maryanna E. Lanning

¹ and

Steven Fletcher

^1,2,*

¹

Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N. Pine St., Baltimore, MD 21201, USA

²

University of Maryland Greenebaum Cancer Center, 22 S. Greene St., Baltimore, MD 21201, USA

^*

Author to whom correspondence should be addressed.

Biology 2015, 4(3), 540-555; https://doi.org/10.3390/biology4030540

Submission received: 21 July 2015 / Revised: 11 August 2015 / Accepted: 14 August 2015 / Published: 31 August 2015

Download

Browse Figures

Versions Notes

Abstract

α-Helices often recognize their target proteins at protein–protein interfaces through more than one recognition face. This review describes the state-of-the-art in the design of non-peptidic α-helix mimetics that reproduce functionality from multiple faces of an α-helix.

Keywords: α-helix mimetic; protein–protein interaction; proteomimetic; amphipathic; cancer; Bcl-2; HMD2; Bak; Bim; p53

Graphical Abstract

Share and Cite

MDPI and ACS Style

Lanning, M.E.; Fletcher, S. Multi-Facial, Non-Peptidic α-Helix Mimetics. Biology 2015, 4, 540-555. https://doi.org/10.3390/biology4030540

AMA Style

Lanning ME, Fletcher S. Multi-Facial, Non-Peptidic α-Helix Mimetics. Biology. 2015; 4(3):540-555. https://doi.org/10.3390/biology4030540

Chicago/Turabian Style

Lanning, Maryanna E., and Steven Fletcher. 2015. "Multi-Facial, Non-Peptidic α-Helix Mimetics" Biology 4, no. 3: 540-555. https://doi.org/10.3390/biology4030540

APA Style

Lanning, M. E., & Fletcher, S. (2015). Multi-Facial, Non-Peptidic α-Helix Mimetics. Biology, 4(3), 540-555. https://doi.org/10.3390/biology4030540

Article Menu

Multi-Facial, Non-Peptidic α-Helix Mimetics

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI