The Republic of Turkey was established in 1923 out of the remains of the Ottoman Empire. Between 1923 and 1938, the Turkish republic underwent fifteen years of rapid expansion and growth, with Ankara as its new capital and Mustafa Kemal Atatürk...
Climate change is shifting building thermal demand from heating toward cooling, yet quantitative, design-relevant projections for semi-arid continental cities remain scarce. This study projects heating and cooling degree days (HDDs and CDDs) for Anka...
The production of several viral vaccines depends on chicken embryo fibroblasts or embryonated chicken eggs. To replace this logistically demanding substrate, we created continuous anatine suspension cell lines (CR and CR.pIX), developed chemically-de...
In the presented study, the effects of ROCK inhibitor Y-27632, antifreeze protein III, and boron at two different doses were investigated on the spermatological parameters of Ankara buck semen after freeze–thawing. Ejaculates were collected fro...
Background: Zika virus (ZIKV) is a mosquito-borne flavivirus associated with severe neurological disease, including congenital Zika syndrome (CZS) following utero infection and Guillain–Barré syndrome in adults. The 2015–2016 epide...
Modified vaccinia virus Ankara (MVA) is the vector of choice for human and veterinary applications due to its strong safety profile and immunogenicity in vivo. The use of MVA and MVA-vectored vaccines against human and animal diseases must comply wit...
The necessity of exploring the relationship between sleep quality and the thermal environment has amplified regarding increasing heat stress risk on the human body due to climate change, particularly in vulnerable uninsulated buildings in Ankara. Wit...
Respiratory viruses infections caused by influenza viruses, human parainfluenza virus (hPIV), respiratory syncytial virus (RSV) and coronaviruses are an eminent threat for public health. Currently, there are no licensed vaccines available for hPIV, R...
Background/Objectives: Bovine viral diarrhea (BVD) is a major infectious disease of cattle caused by bovine viral diarrhea virus genotypes 1 and 2 (BVDV-1 and BVDV-2). Current inactivated and live attenuated vaccines provide incomplete cross-genotype...
While vectored vaccines, based on hyperattenuated viruses, may lead to new treatment options against infectious diseases and certain cancers, they are also complex products and sometimes difficult to provide in sufficient amount and purity. To facili...
As marked by escalating urban crises, socio-spatial fragmentation, and environmental uncertainty, the resilience of cities increasingly depends on their capacity to foster inclusive and sustainable modes of everyday interaction. Within this context,...
Prevention of mpox has become an important public health interest. We aimed to evaluate the safety and immunogenicity of the Modified Vaccinia Ankara (MVA) vaccine. We conducted a systematic review and meta-analysis of randomized-controlled trials (R...
The urgent need for vaccines against Ebola virus (EBOV) was underscored by the large outbreak in West Africa (2014–2016). Since then, several promising vaccine candidates have been tested in pre-clinical and clinical studies. As a result, two v...
Modified vaccinia Ankara (MVA) virus is a widely used vaccine platform, making accurate titration essential for vaccination studies. However, the current plaque forming unit (PFU) assay, the standard for MVA titration, is prone to observer bias and o...
African swine fever (ASF) has become a global threat to the pig industry and wild suids. Within Europe, including Germany, affected wild boar populations play a major role. Fencing and carcass removal in combination with the reduction in environmenta...
Background: Modified Vaccinia Ankara (MVA) vectors are highly immunogenic vaccine platforms for the delivery of recombinant antigens. Efficient downstream processing is still challenging, particularly because substantial fractions of the virus remain...
In South Korea, despite the increase in emerging viral pathogens in the veterinary industry, only efficacy-tested, virus-specific disinfectants are allowed to be used. Moreover, domestic testing of disinfectants for their virucidal efficacies against...
Parrot bornaviruses (PaBVs) are the causative agents of proventricular dilatation disease (PDD), a chronic and often fatal neurologic disorder in Psittaciformes. The disease is widely distributed in private parrot collections and threatens breeding p...
Background: The Epstein-Barr virus (EBV) is intricately linked to a range of human malignancies, with EBV latent membrane protein 2A (LMP2A) emerging as a potential target antigen for immunotherapeutic strategies in the treatment of nasopharyngeal ca...
Chronic hepatitis B virus (HBV) infection affects 257 million people globally. Current therapies suppress HBV but viral rebound occurs on cessation of therapy; novel therapeutic strategies are urgently required. To develop a therapeutic HBV vaccine t...
Background/Objectives: Marburg virus (MARV) is the etiological agent of Marburg Virus Disease (MVD), a rare but severe hemorrhagic fever disease with high case fatality rates in humans. Smaller outbreaks have frequently been reported in countries in...
Ex situ and in situ conservation are the two most important methods for preserving and sustaining natural species. However, studies that combine in situ and ex situ studies are rather scarce. Ankara, the capital of Türkiye, is a rich biodiversit...
The modified vaccinia virus Ankara (MVA), a severely attenuated strain of vaccinia virus, is a promising vector platform for viral-vectored vaccine development because of its attributes of efficient transgene expression and safety profile, among othe...
Background/Objectives: Understanding the regional distribution of human papillomavirus (HPV) genotypes is essential for guiding effective vaccination and screening strategies. This study aimed to assess the prevalence and distribution of HPV genotype...
Background: Acromegaly is a rare, chronic, systemic, and progressive disease characterized by an excess secretion of growth hormone (GH) and increased circulating insulin-like growth factor 1 (IGF-1) concentrations, typically due to a macroadenoma in...
Urban areas may be affected by multiple hazards, and integrated hazard susceptibility maps are needed for suitable site selection and planning. Furthermore, geological–geotechnical parameters, construction costs, and the spatial distribution of...
The increasing impacts of climate change and drought have made water-efficient management of urban green spaces a critical issue in semi-arid cities. This study evaluates the water-saving potential of xeriscape landscape design principles in two majo...
Antimicrobial resistance in companion animals is a growing public health concern, yet data on last-resort resistance genes in clinical canine isolates remain scarce. This study characterizes the molecular distribution of critical resistance determina...
Locating electric vehicle charge stations has always been an important problem for electric distributers. Many basic and complex solutions have been provided by algorithms and methods to solve this problem in real and assumed grids. However, the data...
Poppy is a minor agronomic field crop that is cultivated under a UN license. It is known for its alkaloids and seeds, and, rarely, for the latter’s use in ethnomedicine. Changing climate conditions could lead to the need for alternate areas for...
In the context of sustainable banking, this study examines the relationships between customers’ perceptions of corporate social responsibility (CSR), their evaluations of a bank’s financial performance, and the positive and negative emoti...
Geographical Information Systems (GIS) have been gaining a growing interest in Turkey. Many local governments and public agencies have been struggling to set up such systems to serve the needs and meet public requirements. Urban life shelters the adv...
Modified vaccinia virus Ankara (MVA) is a promising viral vector for vaccine development. MVA is well studied and has been widely used for vaccination against smallpox in Germany. This review describes the history of the origin of the virus and its p...
There is a need to develop a highly effective vaccine against the emerging chikungunya virus (CHIKV), a mosquito-borne Alphavirus that causes severe disease in humans consisting of acute febrile illness, followed by chronic debilitating polyarthralgi...
This study presents a comprehensive global accuracy assessment of the medium-range (up to 15 days) forecast pressure-level data generated by the physics-based Integrated Forecast System (IFS) and the newly operational, data-driven Artificial Intellig...
The usage of OpenStreetMap (OSM), one of the resources offered by Volunteered Geographic Information (VGI), has rapidly increased since it was first established in 2004. In line with this increased usage, a number of studies have been conducted to an...
Camelpox is a viral contagious disease of Old-World camelids sustained by Camelpox virus (CMLV). The disease is characterized by mild, local skin or severe systemic infections and may have a major economic impact due to significant losses in terms of...
Zika virus (ZIKV) is an emerging mosquito-borne flavivirus that has spread to more than 70 countries worldwide since 2015. Despite active research, there are currently no licensed vaccines or therapeutics. We have previously reported the development...
Background/Objectives: The objective of this study was to investigate the factors influencing adherence with tuberculosis medication therapy. Non-adherence can result in treatment failure, ongoing infectiousness, and the development of drug resistanc...
The Modified Vaccinia virus Ankara (MVA) is a highly attenuated vaccinia virus serving as a promising vector vaccine platform to develop vaccines against infectious diseases. In contrast to the well-established replication deficiency and safety of MV...
Background/Objectives: Poxviruses are large DNA viruses that replicate in the host cytoplasm without a nuclear phase. As vaccine vectors, they can package and express large recombinant cassettes from different positions of their genomic core region....
On the analysis of solar radiation and meteorological variables measured in Ankara province in Türkiye from 2017 to 2018, an empirical model of global solar radiation was developed. The global solar radiation at the ground and at the top of the...
Background: Old World orthohantaviruses are the aetiological agent of Haemorrhagic Fever with Renal Syndrome (HFRS) disease. Worldwide, the two most prominent pathogens of HFRS are Seoul orthohantavirus (SEOV) and Hantaan orthohantavirus (HTNV). Ther...
Surrogate viruses provide a safe and scalable alternative for evaluating disinfectant efficacy when access to high-risk pathogens is restricted. This study evaluated the potential of Modified Vaccinia Ankara (MVA) virus, which can be handled under BS...
Background: The recent resurgence of mpox in central Africa has been declared a new public health emergency of international concern (PHEIC) requiring coordinated international responses. Vaccination is a priority to expand protection and enhance con...
Objective: To evaluate and compare fetal arterial and venous Doppler parameters in early-onset (EO) and late-onset (LO) fetal growth restriction (FGR), and to assess their performance within the study cohort and their association with composite adver...
Zika virus (ZIKV) is a mosquito-borne flavivirus whose infection in pregnant women is associated with a spectrum of birth defects, which are together referred as Congenital Zika Syndrome. In addition, ZIKV can also induce Guillain–Barré...
This study presented whole-rock elemental and Sr-Nd isotope geochemistry data with the purpose to decipher the origin and evolution of the Miocene Elmadağ Volcanic Complex, Central Anatolia (Ankara, Turkey). Volcanic products spanned in composition f...
Lassa fever surpasses Ebola, Marburg, and all other hemorrhagic fevers except Dengue in its public health impact. Caused by Lassa virus (LASV), the disease is a scourge on populations in endemic areas of West Africa, where reported incidence is highe...
The product of grapes with the highest added value is wine. Wine grapes play an important role in the evaluation of barren lands, where no other plants generally grow. Viticulture in Türkiye is generally conducted on small areas of agricultural...
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