Immune Response to Dengue Viral Infection
A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Vaccines against Tropical and other Infectious Diseases".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 194
Special Issue Editors
Interests: dengue virus; SARS-CoV-2; infectious diseases; immune; neutralizing antibody
Special Issue Information
Dear Colleagues,
Dengue virus (DENV), a mosquito-borne flavivirus, poses a significant global health burden, with over 100 million symptomatic infections annually. The immune response to DENV infection is a double-edged sword: while adaptive immunity can confer long-term serotype-specific protection, cross-reactive antibodies and T-cells may exacerbate disease severity during secondary heterotypic infections, a phenomenon known as antibody-dependent enhancement (ADE). Innate immune mechanisms, including interferon signaling, dendritic cell activation, and inflammatory cytokine production, play critical roles in early viral control but may also contribute to immunopathology in severe dengue (e.g., hemorrhagic fever and shock syndrome). Current research focuses on unraveling the balance between protective and pathogenic immune responses, identifying correlates of protection, and understanding how viral evolution and host genetic factors modulate immunity.
This Special Issue explores advances in molecular immunology, vaccine design (e.g., live-attenuated, subunit, or mRNA platforms), and therapeutic strategies targeting host immune pathways. Topics also include cross-protective immunity, the role of pre-existing immunity to related flaviviruses (e.g., Zika), and innovative biomarkers for predicting disease progression. Contributions addressing gaps in diagnostics, vaccine efficacy, and immunomodulatory therapies are encouraged to inform global dengue control efforts.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:
- Dengue virus infection;
- Immune response;
- Antibody-dependent enhancement (ADE);
- Cross-reactive immunity;
- Viral pathogenesis;
- Cytokine storm;
- Neutralizing antibodies;
- T-cell response;
- Vaccine development;
- Dengue serotypes;
- Host–pathogen interactions.
We look forward to receiving your contributions.
Prof. Bo Peng
Dr. Xiaolu Shi
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- dengue virus infection
- immune response
- immunity
- viral infection
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