This study established a model for price determinants with the combination of the GIS technique and spatial regression model based on the parcel prices of multiplex houses in an effort to integrate and utilize spatial data and choose a suitable model...
The tumor microenvironment is a complex ecosystem containing various cell types, such as immune cells, fibroblasts, and endothelial cells, which interact with the tumor cells. In recent decades, the cancer research field has gained insight into the c...
Fiber-optic ball resonators are an attractive technology for refractive index (RI) sensing and optical biosensing, as they have good sensitivity and allow for a rapid and repeatable manufacturing process. An important feature for modern biosensing de...
Mode conversion effects in Fibre Bragg Gratings (FBGs) are widely exploited in applications such as sensing and fibre lasers. However, when FBGs are inscribed into Few-mode optical Fibres (FMFs), the mode interactions become highly complex due to the...
Technological advancements have enabled the active control of electromagnetic waves. Metalenses, known for their precision in wavefront shaping and functional versatility, represent a breakthrough in optical modulation. This study addresses the chall...
Background and Aims: Intrahepatic mononuclear phagocytes (MPs) are critical for the initiation and progression of liver fibrosis. In this study, using multiplexed digital spatial protein profiling, we aimed to derive a unique protein signature predic...
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of many solid tumors. In breast cancer (BC), immunotherapy is currently approved in combination with chemotherapy, albeit only in triple-negative breast cancer. Unfortunately, most...
Fiber-optic interferometric sensors based on graded-index multimode fibers have very high refractive-index sensitivity, as we previously demonstrated. In this paper, spatial-frequency multiplexing of this type of fiber-optic refractive index sensors...
As single-mode-fiber transmission systems are reaching their capacity limits, spatial-division multiplexing (SDM) techniques have been investigated to increase the per-fiber capacity. However, the compatibility with current single-mode transponders s...
Non-small cell lung cancer (NSCLC) remains a cause of significant morbidity and mortality, despite significant advances made in its treatment using immune checkpoint inhibitors (ICIs) over the last decade; while a minority experience prolonged respon...
Ultrafast laser processing can produce micro/nanostructures, which is of great interest in advanced manufacturing. Ultrafast laser-induced events include non-equilibrium dynamic phenomena, occurring on the femtosecond to picosecond time scale and nan...
In the last 15 years, global data traffic has been doubling approximately every 2–3 years, and there is a strong indication that this pattern will persist. Hence, also driven by the emergence of new applications and services expected within the...
Metalenses composed of a large number of subwavelength nanostructures provide the possibility for the miniaturization and integration of the optical system. Broadband polarization-insensitive achromatic metalenses in the visible light spectrum have a...
The tumor immune microenvironment (TIME) is an important player in breast cancer pathophysiology. Surrogates for antitumor immune response have been explored as predictive biomarkers to immunotherapy, though with several limitations. Immunohistochemi...
We present a flexible holographic system based on spatial frequency division multiplexing for single-shot, multi-depth, full-field tomographic imaging. In this system, a specially designed sequence light generator containing a group of optical path d...
In this article, a computationally-efficient approach is presented for Bit Error Rate (BER) calculations in multi-user Multiple Input Multiple Output (MIMO) frequency selective fading environments, operating in spatial multiplexing transmission mode....
Physical-layer security offers low probability of interception (LPI) in wireless communication systems. While prior methods such as the directional beamforming and secrecy coding schemes require knowledge of the eavesdropper (Eve)’s channel, pa...
pH (low) insertion peptides (pHLIPs) have been developed for cancer imaging and therapy targeting the acidic extracellular microenvironment. However, the characteristics of intratumoral distribution (ITD) of pHLIPs are not yet fully understood. This...
With the growing need for high-density data and real-time communication, multimode optical fibers (MMFs) have emerged as a vital technology due to their ability to transmit multiple optical modes simultaneously through spatial division multiplexing (...
This study proposes two approaches for improving the effectiveness of spatial modulation integrated into layer division multiplexing (SM-LDM) in broadcasting systems: biased-power allocation (Bi-PA) and shared antenna selection (SAS). Even though dif...
The phase-sensitive optical time domain reflectometry (Φ-OTDR) has been widely applied in various fields. However, due to fading noise, false alarms often occur; this limits its engineering applications. In this paper, a fading suppression method...
We present a review of photonic implementations of discrete-time quantum walks (DTQW) in the spatial and temporal domains, based on spatial- and time-multiplexing techniques, respectively. Additionally, we propose a detailed novel scheme for photonic...
Direct antibody labeling is essential for immunoassays, multiplexed imaging, and biosensing; however, current methods are often time-consuming, restricted by antibody source, risk compromising protein performance, or vary with multiple steps. We intr...
While RNA sequencing and multi-omic approaches have significantly advanced cancer diagnosis and treatment, their limitation in preserving critical spatial information has been a notable drawback. This spatial context is essential for understanding ce...
Information capacity of single-mode fiber communication systems face fundamental limitations imposed by optical nonlinearities. Spatial division multiplexing (SDM) offers a new dimension for upgrading fiber communication systems. Many enabling integr...
To overcome atmospheric turbulence (AT) distortion during signal propagation through the optical link, orbital angular momentum (OAM) mode states employing multiple inputs and multiple outputs (MIMO) techniques have recently gained prominence in free...
High-multiplex detection of protein biomarkers across tissue regions has been an attractive spatial biology approach due to significant advantages over traditional immunohistochemistry (IHC) methods. Different from most methods, spatial multiplex in...
In the last three decades, light’s orbital angular momentum (OAM) has been of great interest because it has unique characteristics that make it sought after in many research fields, especially in optical communications. To address the exponenti...
We demonstrate a spatial division multiplexing (SDM) network testbed composed of three nodes connected via 19-core multi-core fibers. Each node is capable of joint spatial circuit switching and joint packet switching to support 10 Tb/s spatial circui...
Multiplexed platforms for multiple epitope detection have emerged in the last years as very powerful tools to study tumor tissues. These revolutionary technologies provide important visual techniques for tumor examination in formalin-fixed paraffin-e...
Cellular communication provides an efficient, flexible, long-lived, and reliable communication technology for smart grids to improve the automated analysis, demand response, adoptive control, and coordination between the generator and consumers. With...
Pathology has always been a spatial science: for more than 150 years, diagnosis has rested on reading the architecture of cells and tissues. Three technological streams are now converging on this founding principle. Spatially resolved omics can measu...
The life sciences are currently undergoing a serious transition from the reductive biochemical analysis of dissociated tissues to non-destructive “spatial forensics”. In addition to discovering new molecules, we are moving towards finding...
Low-Power Wide-Area Network (LPWAN) technologies play a central role in large-scale wireless sensor network (WSN) deployments, where energy efficiency, coverage and reliability dominate over throughput. Among them, Long Range (LoRa) technology has em...
Spatial relations between tumor cells and host-infiltrating cells are increasingly important in both basic science and clinical research. In this study, we have tested the feasibility of using standard methods of immunohistochemistry (IHC) in a multi...
Orthogonal frequency division multiplexing (OFDM) technology is presented for use in free-space optical (FSO) communications accompanied by the spatial diversity reception. Using quadrature phase shift keying (QPSK) modulation formats, the OFDM signa...
Although immune checkpoint inhibitors (ICIs) have significantly improved the oncological outcomes, about one-third of patients affected by clear cell renal cell carcinoma (ccRCC) still experience recurrence. Current prognostic algorithms, such as the...
The global expansion of 5G and the approaching 6G era are pushing conventional single-mode fibers toward their fundamental capacity limits, necessitating a paradigm shift in optical network infrastructure. This study introduces a novel, AI-optimized...
The pumping of Tm-doped crystal or fiber by a 792 nm semiconductor laser is an important way to generate a mid-infrared laser, which is widely used in various fields. In this paper, a high–power 792 nm fiber–coupled semiconductor laser mo...
Multi-plane light converters (MPLC) are a means of deconstructing a wavefront into constituent modes that are focused at specific spatial locations, and the reverse—that specific inputs result in controlled modal output. We have used a pair of...
This paper presents a novel integration of quadrature amplitude modulation (QAM)-based fast optical orthogonal frequency-division multiplexing (F-OFDM) with machine learning (ML)-based equalization in spatial division multiplexing (SDM) applications,...
This paper presents a long-range experimental demonstration of multi-mode multiple-input multiple-output (MIMO) transmission using orbital angular momentum (OAM) waves for Line-of-Sight (LoS) wireless backhaul applications. A 4 × 4 MIMO system...
We report an atmospheric multichannel data transmission system with channel separation by vortex beams of various orders, including half-integer values. For the demultiplexing of the communication channels, a multichannel diffractive optical element...
The use of digital signal processors (DSP) to equalize coherent optical communication systems based on spatial division multiplexing (SDM) techniques is widespread in current optical receivers. However, most of DSP implementation approaches found in...
This paper studied the general mechanism of spatial-frequency-shift (SFS) super-resolution imaging based on multiplex illumination modulation. The theory of SFS joint intensity was first proposed. Experiments on parallel slots with discrete spatial f...
Telecommunications have grown to be a pillar to a functional society and the urge for reliable and high throughput systems has become the main objective of researchers and engineers. State-of-the-art work considers massive Multiple-Input Multiple-Out...
Electro-optical imaging sensors are widely distributed and used for many different tasks. Due to technical improvements, their pixel size has been steadily decreasing, resulting in a reduced saturation capacity. As a consequence, this progress makes...
Immune complexity status in the TME has been linked to clinical outcomes in pancreatic ductal adenocarcinoma (PDAC) patients. TME assessments with current cell marker and cell density-based analyses do not identify the original phenotypes of single c...
Background: Phosphaturic mesenchymal tumours secreting fibroblast growth factor 23 (hereinafter referred to as FGF23+ PMT) are rare neoplasms that can cause hypophosphataemic osteomalacia, owing to excessive FGF23 production. Mast cells (MCs) play a...
Whispering gallery mode resonators have proven to be robust and sensitive platforms for the trace detection of chemical and/or biological analytes. Conventional approaches using serially addressed resonators face challenges in simultaneous multi-chan...
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