As the application of bone scaffolds becomes more and more widespread, the requirements for the high performance of bone scaffolds are also increasing. The stiffness and porosity of porous structures can be adjusted as needed, making them good candid...
An attached cantilever scaffold, which mainly consists of a cantilever horizontal steel beam and a diagonal bar, is a new type of cantilever scaffold. The upper end of the diagonal bar is attached to an upper floor slab by a hinge, while the lower en...
This research paper explores the development of AI-optimized lattice structures for biomechanics scaffold design, aiming to enhance bone implant functionality by utilizing advanced human–AI systems. The primary objective is to create scaffold s...
Triply periodic minimal surfaces (TPMS) became an effective method to design porous scaffolds in recent years due to their superior mechanical and other engineering properties. Since the advent of additive manufacturing (AM), different TPMS-based sca...
In spite of the rather large use of the fused deposition modeling (FDM) technique for the fabrication of scaffolds, no studies are reported in the literature that optimize the geometry of such scaffold types based on mechanobiological criteria. We im...
Triply Periodic Minimal Surfaces (TPMSs) are mathematically defined surfaces that exhibit periodicity in three dimensions while maintaining a minimal surface property. TPMS-based lattices have gained significant attention in recent years, fueled by a...
Additive manufacturing technology, specifically material extrusion, offers great potential for scaffold manufacturing in tissue engineering. This study presents a novel methodology for the design and optimization of 3D printed polymeric scaffolds to...
The construction of artificial biological tissues presents complex interdisciplinary challenges, requiring the convergence of knowledge from materials science, biophysics, biology, design, and related fields. The interaction between cells and the ext...
The generation of 3D structures comprises three interlinked phases: material development, the printing process, and post-printing treatment. Numerous factors control all three phases, making the optimization of the entire process a challenging task....
In the implantation of porous bone scaffolds, good mechanical properties of the scaffold are a prerequisite for the long-term functionality of the implanted scaffolds, which varies according to the structure and the forming process. In this study, th...
Porous scaffolds fabricated via fused deposition modeling (FDM) are promising for bone tissue engineering, but their mechanical performance and geometric fidelity are governed by complex interactions between process parameters and architectural desig...
Fall-from-height fatalities in underground construction are closely associated with formwork scaffold operations, where dense steel members cause severe non-line-of-sight (NLOS) and multipath effects that degrade positioning performance. Although ult...
Tissue engineering has the potential for repairing large bone defects, which impose a heavy financial burden on the public health. However, difficulties with O2 delivery to the cells residing in the interior of tissue engineering scaffolds make it ch...
Human bone is composed of organic and inorganic composite materials, contributing to its unique strength and flexibility. Hydroxyapatite (HAP) has been extensively studied for bone regeneration, due to its excellent bioactivity and osteoconductivity,...
To improve the performance of porous tantalum (Ta) manufactured by laser powder bed fusion (L-PBF) and meet its application requirements in medicine, the authors of this paper studied the influence of L-PBF process parameters on the strut surface mor...
Aurones, particular polyphenolic compounds belonging to the class of minor flavonoids and overlooked for a long time, have gained significative attention in medicinal chemistry in recent years. Indeed, considering their unique and outstanding biologi...
Small-molecule HIV-1 entry inhibitors are an extremely attractive therapeutic modality. We have previously demonstrated that the entry inhibitor class can be optimized by using computational means to identify and extend the chemotypes available. Here...
Among all types of TGFβ signal blockers, small molecule kinase inhibitors (SMKIs) have attracted wide attention due to their economical production, obvious stability, and ease of oral administration. Nevertheless, SMKIs of TGFβRItypically h...
Bone scaffolds mimicking the three-dimensional bone structure are of essential importance for bone regeneration. The aim of this study was to develop and optimize the production method of highly macroporous bone scaffold composed of polysaccharide ma...
Histone deacetylases (HDAC) are epigenetic enzymes responsible for repressing gene expression through the deacetylation of histone lysine residues. Therefore, inhibition of HDACs has become an interesting approach for the treatment of several disease...
Bone-related defects that cannot heal without significant surgical intervention represent a significant challenge in the orthopedic field. The use of implants for these critical-sized bone defects is being explored to address the limitations of autog...
Optimizing nanofiber morphology is essential for promoting osteoblast elongation and supporting bone regeneration. This study aimed to develop a machine-learning framework capable of predicting optimal scaffold architectures directly from scanning el...
A 3D bioprinted pseudo-bone drug delivery scaffold was fabricated to display matrix strength, matrix resilience, as well as porous morphology of healthy human bone. Computer-aided design (CAD) software was employed for developing the 3D bioprinted sc...
Radial flow perfusion of cell-seeded hollow cylindrical porous scaffolds may overcome the transport limitations of pure diffusion and direct axial perfusion in the realization of bioengineered substitutes of failing or missing tissues. Little has bee...
Aberrant activation of fibroblast growth factor receptor 1 (FGFR1) drives tumor progression in multiple cancer types, yet existing FGFR1 inhibitors suffer from suboptimal target selectivity and dose-limiting toxicities. This study describes an integr...
One of the hottest topics in current research is the creation of scaffolds for bone tissue restoration that are both biocompatible and tissue inducible. The aim of this work is to develop a numerical model to study the effects of temperature, velocit...
Biomaterials play a central role in tissue engineering and regeneration by providing scaffolds that support cell adhesion, proliferation and differentiation while modulating the surrounding microenvironment. They represent promising alternatives to t...
In biomaterial-based bone tissue engineering, optimizing scaffold structure and composition remains an active field of research. Additive manufacturing has enabled the production of custom designs in a variety of materials. This study aims to improve...
The purpose of the current investigation was to evaluate the clinical success of horizontal ridge augmentation in severely atrophic maxilla (Cawood and Howell class IV) using freeze-dried custom made bone harvested from the tibial hemiplateau of cada...
A method to characterize the mechanical properties of cellular materials manufactured using 3D printing, specifically employing the fused deposition modeling (FDM) technique, is developed. Numerical simulations, virtual testing, and optimization base...
Developments in selective laser melting (SLM) have enabled the fabrication of periodic cellular lattice structures characterized by suitable properties matching the bone tissue well and by fluid permeability from interconnected structures. These mult...
Due to the morphological resemblance between the electrospun nanofibers and extracellular matrix (ECM), electrospun fibers have been widely used to fabricate scaffolds for tissue regeneration. Relationships between scaffold morphologies and cells are...
Despite the wide use of scaffolds with spherical pores in the clinical context, no studies are reported in the literature that optimize the micro-architecture dimensions of such scaffolds to maximize the amounts of neo-formed bone. In this study, a m...
3D printed scaffolds can be used, for example, in medical applications for simulating body tissues or for manufacturing prostheses. However, it is difficult to print porous structures of specific porosity and pore size values with fused deposition mo...
Extrusion-based three-dimensional (3D) bioprinting has enabled the fabrication of complex, cell-laden constructs; however, process parameter selection remains largely empirical and system-specific. As biofabrication workflows scale in complexity and...
When designing scaffolds for bone tissue engineering (BTE), the wall shear stress (WSS), due to the fluid flow inside the scaffold, is an important factor to consider as it influences the cellular process involved in new tissue formation. The present...
Enzyme engineering is an indispensable tool in the field of synthetic biology, where enzymes are challenged to carry out novel or improved functions. Achieving these goals sometimes goes beyond modifying the primary sequence of the enzyme itself. The...
Vascular graft failure rates remain unacceptably high due to thrombosis and poor integration, necessitating innovative solutions. This study optimized plant-derived extracellular matrix scaffolds as a scalable and biocompatible alternative to synthet...
Scaffolds are widely recognized as implantable alternatives in the field of tissue engineering. Among various scaffold structures, grid structures are commonly used due to their simple design and ease of fabrication. However, grid structures have a c...
Critical-sized bone defects or CSDs result from bone loss due to trauma, tumor removal, congenital defects, or degenerative diseases. Though autologous bone transplantation is the current gold standard in treating CSDs, its limitations include donor-...
The main aim of this paper is to achieve the suitable SA-GEL (sodium alginate and gelatin) porous cartilage scaffold by 3D printing technology with optimal prediction parameters. Firstly, the characteristics of SA-GEL were analyzed, the influence of...
Background: Three-dimensional (3D) printed scaffolds have emerged as promising tools for bone regeneration, but the optimal structural design and pore size remain unclear. Polylactic acid (PLA) reinforced with graphene oxide (GO) offers enhanced mech...
In this study, promising compositions of cross-linked gelatin-based scaffolds were tested in vitro and in vivo. Our aim was to utilize a solid matrix that is suitable for medical applications, and to be regulated as a medical device as a soft tissue...
Background: Bone tissue engineering has emerged as a promising technique for treating bone defects in large bones. Recent methods have enabled scaffold designs based on predefined microstructures or mechanical behavior patterns, including porosity-gr...
Selecting the appropriate temporary facilities is important for reducing cost and improving the productivity and safety of craft professionals in construction projects. However, the manual planning process for scaffolding systems is typically prone t...
Additive manufacturing has emerged as a transformative tool in biomedical engineering, offering precise control over scaffold design for bone tissue engineering and regenerative medicine. While much attention has been focused on optimizing pore-based...
This study presents a numerical investigation into the hydrodynamic and biomechanical performance of bone-repair scaffolds based on Triply Periodic Minimal Surfaces (TPMSs). Focusing on Gyroid and Diamond architectures, scaffolds with uniform (40–70%...
The latest developments in tissue engineering scaffolds have sparked a growing interest in the creation of controlled 3D cellular structures that emulate the intricate biophysical and biochemical elements found within versatile in vivo microenvironme...
Demineralized bone matrix (DBM) is an excellent bone scaffold material, but is available in only limited sizes. An additive manufacturing (AM) method that retains these properties while enabling customized geometry fabrication would provide bone scaf...
The treatment of osteochondritis dissecans of the knee has always been a challenge for orthopedic surgeons. We present a case report of a 38-year-old male with severe right knee pain after suffering from an indirect trauma and axial rotation of the k...
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