Special Issue "Design of Materials for Bone Tissue Scaffolds"
Deadline for manuscript submissions: 31 May 2021.
Interests: bioengineering; morphological optimization of biomaterials; modeling and simulation of biomedical devices and mechanobiological processes; optical techniques for reverse engineering; characterization of biomedical materials
The recent development of additive manufacturing techniques has allowed the building of regular scaffolds made from a very wide gamma of biocompatible materials and including complex and sophisticated geometries that can be optimized to increase the scaffold performance in terms of mechanical resistance and mechanobiological properties. This has made the design process of materials for bone tissue scaffolds an issue of crucial importance and the object of study of many researchers throughout the world. It is commonly known, in fact, that the rate of bone tissue regeneration and the cellular response is significantly influenced by the scaffold structural response that is, in turn, a function of the scaffold micro-architecture and of the mechanical properties of the material it is made from. The adhesion of stem cells to the scaffold surface as well as the tissue differentiation process occurring in the scaffold pores, are regulated by mechanobiological mechanisms taking place at both the micro- (i.e. some micrometers, approximately the dimension of a stem cell) and macro- (i.e. some hundreds of micrometers, the dimension of scaffold pores) level, respectively. The scaffold surface must be adequately structured to favor the adhesion of stem cells and their consequent differentiation. Similarly, the scaffold architecture must be properly shaped and the scaffold material must be adequately designed to trigger favorable biophysical stimuli, leading to the formation of the bony tissue.
Different studies have recently been published with the aim of better understanding the relationship between the scaffold geometry/material properties and the consequent mechanobiological phenomena taking place inside the scaffold during the regeneration process. However, no clear explanations are yet available on the relationship existing between the mechanical environment and the consequent biological response of tissues occupying the scaffold pores. This Special Issue will gather papers by materials scientists and bone tissue engineers focusing on (but not limited to):
- design techniques to optimize the scaffold performance;
- design of microstructured surfaces to favor the adhesion of stem cells;
- in vitro/in vivo studies aimed to establish relationships between the scaffold structural response and the tissue regeneration process;
- development of innovative biomaterials to fabricate scaffolds for bone tissue engineering;
- optimization of additively manufactured materials to increase scaffold performance;
- computational mechanobiological models simulating the tissue differentiation process in scaffolds.
Dr. Antonio Boccaccio
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Geometry optimization of scaffolds
- Micro-structured surfaces
- Cell adhesion
- Computational mechanobiology
- Additively manufactured materials
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
1. Lactoferrin-Hydroxyapatite Containing Spongy-like Hydrogels for Bone Tissue Engineering
Ana Raquel Bastos1,2, Lucília Pereira da Silva1,2, Fátima Raquel Maia1,2,3, Tânia Rodrigues1,2, Filipa Sousa1,2, Joaquim Miguel Oliveira1,2,3, Jillian Cornish4, Vitor Manuel Correlo1,2,3 and Rui Luís Reis1,2,3
13B's Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal;
2ICVS/3B’s - PT Government Associated Laboratory, Portugal;
3The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, 4805-017 Barco, Guimarães, Portugal;
4Department of Medicine, University of Auckland, Auckland, New Zealand
2. Novel titanium-based scaffolds in bone regeneration: types and application
Maja Antunovic, Maja Pusić, Slaven Babic, Katarina Caput Mihalic and Inga Marijanovic *.
Department of Biology, Faculty of Science, University of Zagreb; Traumatology Clinic, Clinical Hospital Centre “Sestre Milosrdnice”, Zagreb.
Title: Chemical composition and particle size of synthetic ceramics delivered with rhBMP6 in autologous blood coagulum determine the ectopic bone structure in a rat one year follow up study
Authors: Nikola Stokovic1,2; Natalia Ivanjko1,2; Marina Milesevic1,2,; Igor Erjavec1,2; T Kuber Sampath3; Slobodan Vukicevic1,2
Affiliation: 1 Laboratory for Mineralized Tissues, University of Zagreb School of Medicine, Zagreb, Croatia 2 Scientific Center of Excellence for Reproductive and Regenerative Medicine 3 perForm Biologics Inc, Holliston, Massachusetts, USA