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Tissue Engineering Related Biomaterials: Progress and Challenges

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 1482

Special Issue Editors


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Guest Editor
Physical and Colloidal Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania
Interests: biomaterials (collagen drug delivery systems); rheology; cosmeceuticals; drug systems formulation and technological processes optimization; response surface methodology; Taguchi design
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Guest Editor
Physical and Colloidal Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania
Interests: quality by design (QbD); analytical quality by design (AQbD); drug systems formulation (Chitosan); surfaces’ characteristics (wettability/hidrophilicity/hidrophobicity—pharmaceutical powders)
Special Issues, Collections and Topics in MDPI journals

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Guest Editor

Special Issue Information

Dear Colleagues,

This Special Issue offers a comprehensive analysis of the function of biomaterials in the realm of tissue engineering. Tissue engineering is a multidisciplinary domain that seeks to restore or substitute damaged tissues and organs by employing a mix of cells, biomaterials and growth factors. It provides an in-depth examination of the biomaterials used in various procedures, with a specific emphasis on their design, functioning and utilization.

An overview of the fundamental principles behind tissue engineering and biomaterials is provided in this Special Issue. The journal articles could bring to light the biological and mechanical prerequisites of biomaterials employed in tissue engineering, examining the manner in which these materials interact with the biological systems of the human body. These works explore a range of biomaterials, encompassing both natural and synthetic polymers, ceramics or composites, while also analyzing their individual strengths and weaknesses.

The Special Issue intends to give a comprehensive explanation of the methods employed in the production of tissue engineering scaffolds, including electrospinning, 3D printing and gel casting. The papers could highlight the significance of scaffold architecture in facilitating cell development and tissue creation, and also investigate techniques for integrating bioactive substances into these scaffolds to improve their effectiveness.

Furthermore, the articles are intented to explore the evaluation of biomaterials, encompassing techniques for assessing biocompatibility, mechanical characteristics and rates of degradation. Additionally, the manuscripts should address the regulatory factors and difficulties involved in the transition of tissue engineering technology from the laboratory to practical medical applications.

In summary, this Special Issue is an important tool for comprehending the relationship between biomaterials and tissue engineering. It provides valuable perspectives on ongoing research patterns and potential future advancements in this domain.

Therefore, this Special Issue presents a comprehensive overview of current research and developments in the field, offering valuable insights for scientists and industry professionals, and intending to stimulate more investigation and use of innovative biomaterials in tissue engineering by presenting cutting-edge research and applications, opening the door for fresh findings and breakthroughs.

Prof. Dr. Mihaela Violeta Ghica
Prof. Dr. Lacramioara Popa
Prof. Dr. Cristina Elena Dinu-Pirvu
Guest Editors

Manuscript Submission Information

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Keywords

  • biomaterials
  • tissue engineering
  • scaffold materials
  • regenerative medicine
  • cell–material interactions
  • tissue regeneration
  • bioactive materials
  • nanotechnology in tissue engineering
  • electrospinning
  • 3D printing
  • biodegradable materials
  • growth factors

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Published Papers (1 paper)

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Research

15 pages, 3851 KiB  
Article
Optimization and Standardization of Plant-Derived Vascular Scaffolds
by Gianna Imeidopf, Dara Khaimov, Sashane John and Nick Merna
Int. J. Mol. Sci. 2025, 26(6), 2752; https://doi.org/10.3390/ijms26062752 - 19 Mar 2025
Viewed by 1132
Abstract
Vascular graft failure rates remain unacceptably high due to thrombosis and poor integration, necessitating innovative solutions. This study optimized plant-derived extracellular matrix scaffolds as a scalable and biocompatible alternative to synthetic grafts and autologous vessels. We refined decellularization protocols to achieve >95% DNA [...] Read more.
Vascular graft failure rates remain unacceptably high due to thrombosis and poor integration, necessitating innovative solutions. This study optimized plant-derived extracellular matrix scaffolds as a scalable and biocompatible alternative to synthetic grafts and autologous vessels. We refined decellularization protocols to achieve >95% DNA removal while preserving mechanical properties comparable to native vessels, significantly enhancing endothelial cell seeding. Leatherleaf viburnum leaves were decellularized using sodium dodecyl sulfate-based and Trypsin/Tergitol-based treatments, achieved via clearing in bleach and Triton X-100 for 6 to 72 h. To assess the environmental influence on scaffold performance, leaves from multiple collection sites were processed using sodium dodecyl sulfate-based protocols. Scaffold performance was evaluated through tensile testing and histological analysis to assess structural integrity, while DNA quantification and endothelial cell recellularization measured biological compatibility. Sodium dodecyl sulfate-treated scaffolds with shorter clearing durations demonstrated the highest DNA removal (≥95%) while preserving mechanical properties, significantly outperforming Trypsin/Tergitol treatments. Longer clearing times reduced fiber diameter by 60%, compromising scaffold strength. Shorter clearing times preserved extracellular matrix integrity and significantly improved endothelial cell seeding efficiency. Larger leaves supported significantly higher endothelial cell densities than smaller leaves, highlighting the need for standardized material sources. Permeability tests demonstrated minimal leakage at 120 mmHg and structural stability under dynamic flow conditions, suggesting their suitability for vascular applications. These findings establish a reliable framework for optimizing plant-derived grafts, improving their reproducibility and performance for tissue engineering applications. Full article
(This article belongs to the Special Issue Tissue Engineering Related Biomaterials: Progress and Challenges)
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