Next Article in Journal
Effect of Mechanical Stimulation Applied to the Lower-Limb Musculature on Stability and Function of Stair Climbing
Previous Article in Journal
An Ontology-Based Framework for Publishing and Exploiting Linked Open Data: A Use Case on Water Resources Management
Open AccessArticle

Experimental Investigation and Optimal 3D Bioprinting Parameters of SA-Gel Porous Cartilage Scaffold

1
School of Mechanical Engineering, Hangzhou Dianzi University, Hangzhou 310018, China
2
Department of Chemical & Process Engineering, Faculty of Engineering & Built Environment, University Kebangsaan Malaysia, Bangi 43600, Malaysia
3
Faculty of Science and Technology, Zhejiang International Studies University, Hangzhou 310018, China
4
Department of Mechanical and Materials Engineering, Faculty of Engineering & Built Environment, University Kebangsaan Malaysia, Bangi 43600, Malaysia
*
Authors to whom correspondence should be addressed.
Appl. Sci. 2020, 10(3), 768; https://doi.org/10.3390/app10030768
Received: 19 December 2019 / Revised: 8 January 2020 / Accepted: 20 January 2020 / Published: 22 January 2020
(This article belongs to the Section Applied Biosciences and Bioengineering)
The main aim of this paper is to achieve the suitable SA-GEL (sodium alginate and gelatin) porous cartilage scaffold by 3D printing technology with optimal prediction parameters. Firstly, the characteristics of SA-GEL were analyzed, the influence of calcium chloride on the gel was explored, and the optimal cross-linking concentration and gelation temperature were determined. Secondly, a prediction model of the extrusion line width of SA-GEL was established, in which the printing pressure, the moving speed of the needle and the fiber interval were the important parameters affecting the printing performance of the SA-GEL composite material. Thirdly, the SA-GEL composite scaffolds were printed on the Bio-plotter platform, the C5.18 chondrocytes cells were cultured in the SA-GEL biomaterial scaffold, and the results show that the cells could survive well. These results show that, under the control of the printing parameters pressure 1.8 bar, moving speed 10.7 mm/s and the internal structure parameters of the scaffold is 0/45-1.2 (Printing interval: 1.2 mm, angle value: 45 degree), SA-GEL scaffold printing results can be obtained which have good mechanical properties and biocompatibility. View Full-Text
Keywords: biological 3D printing; sodium alginate; gelatin; cartilage scaffold biological 3D printing; sodium alginate; gelatin; cartilage scaffold
Show Figures

Figure 1

MDPI and ACS Style

Gong, Y.; Wang, F.; Al-Furjan, M.S.H.; Shan, L.; He, J.; Bian, X.; Bi, Z.; Liu, H.; Li, W.; Shao, H.; Chen, G.; Sulong, A.B. Experimental Investigation and Optimal 3D Bioprinting Parameters of SA-Gel Porous Cartilage Scaffold. Appl. Sci. 2020, 10, 768.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop