Class I histone deacetylases (HDACs) are promising targets for epigenetic therapies for a range of diseases such as cancers, inflammations, infections and neurological diseases. Although six HDAC inhibitors are now licensed for clinical treatments, t...
Phenological changes in forests directly influence the spatiotemporal dynamics of carbon fixation and the carbon and water cycles in terrestrial ecosystems. Previous studies have shown that variations in biological factors (e.g., canopy height, leaf...
14 January 2022
The COVID-19 pandemic is profoundly affecting the minds and behaviors of people worldwide. This study investigated the differences in the need for structure among people from different social classes and the psychological mechanisms underlying this n...
This paper develops a panel data fixed effect model to analyze the impact of the employment mobility of “Double First-class” college graduates on the rationalization of the industrial structure, advanced industrial structure, high-tech in...
Assessing Green Information Technology (IT) maturity in organizations is a relevant process to measure the progress of sustainable IT initiatives and to support new actions to improve them. Knowledge about the organizational maturity level in Green I...
Viral fusion proteins are indispensable mediators of viral entry that orchestrate the fusion of viral and host membranes, making them primary targets for antiviral interventions. Class I fusion proteins, displayed on the surface of enveloped viruses...
Peripheral nerve blocking (PNB) is a standard procedure to support regional anesthesia. Still, correct localization of the nerve’s structure is needed to avoid adverse effects; thereby, ultrasound images are used as an aid approach. In addition, imag...
South Korea’s successful reforestation efforts over the past 50 years have led to abundant forest resources. However, intensive reforestation during the 1970s and 1980s skewed the forests’ age distribution towards forest stands aged 30 ye...
The traditional Mahalanobis–Taguchi System (MTS) employs two main strategies for multi-class classification: the partial binary tree MTS (PBT-MTS) and the multi-tree MTS (MT-MTS). The PBT-MTS relies on a fixed binary tree structure, resulting i...
In the postgenomic age, rapid growth in the number of sequence-known proteins has been accompanied by much slower growth in the number of structure-known proteins (as a result of experimental limitations), and a widening gap between the two is eviden...
The prior knowledge of protein structural class may offer useful clues on understanding its functionality as well as its tertiary structure. Though various significant efforts have been made to find a fast and effective computational approach to addr...
Ordinal classification (OC) is a sub-discipline of multi-class classification (i.e., including at least three classes), in which the classes constitute an ordinal structure. Applications of ordinal classification can be found, for instance, in the me...
Proteins are characterized by their structures and functions, and these two fundamental aspects of proteins are assumed to be related. To model such a relationship, a single representation to model both protein structure and function would be conveni...
(1) Background: Compounds with multitarget activity are of interest in basic research to explore molecular foundations of promiscuous binding and in drug discovery as agents eliciting polypharmacological effects. Our study has aimed to systematically...
Latent class analysis (LCA) has been applied in many research areas to disentangle the heterogeneity of a population. Despite its popularity, its estimation method is limited to maximum likelihood estimation (MLE), which requires large samples to sat...
It is shown that a simple modification of the standard Lagrangian underlying the dynamics of Newtonian lattices enables one to infer the hidden Lagrangian structure of certain classes of first order in time evolution equations which lack the conventi...
The most promising direction for obtaining a unique combination of difficult-to-combine properties of low-carbon steels is the formation of a dispersed ferrite microstructure and a volumetric system of nanoscale phase precipitates. This study was aim...
The confined uniaxial tests of packings with discrete particle size distribution (PSD) were modeled with the discrete element method. Ternary packings of spheres with PSD uniform or nonuniform by number of particles were examined in three-dimensional...
Variable structure strategy is widely used for the control of sensor-actuator systems modeled by Euler-Lagrange equations. However, accurate knowledge on the model structure and model parameters are often required for the control design. In this pape...
Intrusion detection systems are crucial for cybersecurity applications. Network traffic data originate from diverse terminal sources, exhibiting multi-view feature spaces, while the collection of unknown intrusion data is costly. Current one-class cl...
Although growing urbanization has direct negative consequences for local biodiversity, several native species have been observed maintaining populations in urban environments. Understanding which factors influence the ability of native species to per...
A new class of two-dimensional nanomaterials, MXenes, which are carbides/nitrides/carbonitrides of transition and refractory metals, has been critically analyzed. Since the synthesis of the first family member in 2011 by Yury Gogotsi and colleagues,...
Conventional epoxy adhesives used in motor insulation structures still suffer from insufficient thermal resistance and difficulty in balancing heat resistance with mechanical reliability. In this study, BMI-modified E-51/MeHHPA/EMI-24 epoxy composite...
DLA-88 is a classical major histocompatibility complex (MHC) class I gene in dogs, and allelic DLA-88 molecules have been divided into two categories named “DLA-88*0” and “DLA-88*5.” The defining difference between the two cat...
Deep hashing has gained widespread attention in cross-modal retrieval due to its low cost and efficient retrieval advantages. However, existing cross-modal hashing methods either focus solely on exploring relationships between data points—which...
As part of our continuing research on isoquinoline acaricidal drugs, this paper reports the preparation of a series of the 2-aryl-1-cyano-1,2,3,4-tetrahydroisoquinolines with various substituents on the N-phenyl ring, their in vitro acaricidal activi...
7 July 2023
Background: The COVID-19 pandemic forced medical programs to rapidly switch to remote teaching from scratch, impacting hands-on skills training. This study compared the efficacy of a hybrid online format to a regular in-person session for a mandatory...
Software maintenance is indispensable in the software development process. Developers need to spend a lot of time and energy to understand the software when maintaining the software, which increases the difficulty of software maintenance. It is a fea...
Digital technology has become increasingly prevalent in higher education classrooms. However, the impact of different types and use frequencies of digital technology on college students’ classroom engagement can vary substantially. This study a...
The structure and shape of the polypeptide chains of proteins are determined by the hybridized states of the atomic orbitals in the molecular chain. The calculated s ratio in the spn hybrid orbitals is computed from the fractal dimension D of the ter...
This study evaluates the tracking performance of structural damages in disaster environments by combining YOLOv8 detection with the BoT-SORT tracker. Cracks and exposed rebar, characterized by fine and irregular structures, showed high sensitivity to...
A key step during the entry of enveloped viruses into cells is the merger of viral and cell lipid bilayers. This process is driven by a dedicated membrane fusion protein (MFP) present at the virion surface, which undergoes a membrane–fusogenic...
Objective: This study aimed to explore the direct relationships between social determinants and behavioral clusters, as well as their potential indirect associations mediated by edentulism. Methods: Information on social variables (collected in Wave...
The purpose of this paper is to investigate whether firm ownership characteristics can explain demand for Enterprise Risk Management (ERM) implementation. Specifically, we examine the relationship between the presence of large shareholders, multiple...
The construction industry has a notably negative impact on the environment; thus, the promotion of the use of timber structures is an alternative to mitigate its effects. This research develops an artificial intelligence-based decision approach in th...
This work introduces a framework in which organization is defined as the degree to which identity-defining relationships among system states are preserved under transformation or perturbation. Existing descriptors such as energy, entropy, mutual info...
The Class D β-lactamases have emerged as a prominent resistance mechanism against β-lactam antibiotics that previously had efficacy against infections caused by pathogenic bacteria, especially by Acinetobacter baumannii and the Enterobacteriaceae. Th...
Brain structure segmentation on magnetic resonance (MR) images is important for various clinical applications. It has been automatically performed by using fully convolutional networks. However, it suffers from the class imbalance problem. To address...
We focus on a Bayesian inference framework for finite element (FE) model updating of a long-span cable-stayed bridge using long-term monitoring data collected from a wireless sensor network (WSN). A robust Bayesian inference method is proposed which...
Aiming to advance the coning algorithm performance of strapdown inertial navigation systems, a new half-compressed coning correction structure is presented. The half-compressed algorithm structure is analytically proven to be equivalent to the tradi...
Genetic variants that predict anti-Helicobacter pylori immunoglobulin G (IgG) seropositivity lie almost entirely within the major histocompatibility complex (MHC), which also carries established risk loci for several diseases. Mendelian randomisation...
Although Populus euphratica forests are key components of arid riparian ecosystems, the demographic and competitive processes associated with their population persistence remain insufficiently understood. We investigated population structure, demogra...
Background: Celiac disease (CD) is a multifactorial autoimmune disorder strongly associated with specific HLA class II molecules, particularly HLA-DQ–encoding haplotypes. Although the genetic contribution of these loci is well established, the...
Class III peroxidases (PRXs) are involved in a broad spectrum of physiological and developmental processes throughout the life cycle of plants. However, the specific function of each PRX member in the family remains largely unknown. In this study, we...
Clofazimine, a member of the riminophenazine class of drugs, is the cornerstone agent for the treatment of leprosy. This agent is currently being studied in clinical trials for the treatment of multidrug-resistant tuberculosis to address the urgent n...
Crystallography plays a crucial role in understanding the functions of macromolecules by determining their three-dimensional structures at the atomic level. This review outlines the history of crystallization, explains the principles of crystallizati...
8 October 2023
Recent advances in mathematical modeling and artificial intelligence have challenged the use of traditional regression analysis in biomedical research. This study examined artificial data sets and biomedical data sets from cancer research using binom...
Due to the oncoming climate changes, various environmental stresses (drought, salinity, heavy-metals, low or high temperatures, etc.) might dramatically affect crop yields and the quality of produced foods. Therefore, to meet the growing food demand...
Employers increasingly provide training for working with digital technologies and artificial intelligence (AI), but it is unclear whether the same provision benefits all workers equally. Integrating the job demands–resources (JD-R) model with S...
22 March 2022
We describe patterns of polysubstance use and associations with HIV risk-related behaviors among women engaged in street-based transactional sex, an understudied yet important population and area of research. This sample was restricted to cisgender w...
of 261