In the field of the efficiency of very shallow geothermal energy systems, there is still a significant need for research activity. To ensure the proper exploitation of this energy resource, the decisive geophysical parameters of soil must be well-kno...
Thymidine kinase 1 (TK1) is an intracellular enzyme involved in DNA-precursor synthesis. Increased serum TK1 levels are used as a biomarker in various malignancies. We combined serum TK1 with PSA and evaluated its capacity to predict overall survival...
Taraxacum kok-saghyz Rodin (TKS) is a recognized alternative source of natural rubber comparable to the rubber tree. The geranylgeranyl pyrophosphate synthase (GGPS) catalyzed the synthesis of geranylgeranyl pyrophosphate (GGPP), which is an importan...
Background/Objectives: Periodontitis reflects a dysregulated inflammatory response in which impaired resolution and efferocytosis may play a central role. The TAM receptor MerTK and its ligand growth arrest-specific-6 (Gas6) are key regulators of the...
The scaffold protein Tks4 is a member of the p47phox-related organizer superfamily. It plays a key role in cell motility by being essential for the formation of podosomes and invadopodia. In addition, Tks4 is involved in the epidermal growth factor (...
Extremity trauma, including ischemia (e.g., prolonged tourniquet application or crush), is common among battlefield injuries. Injured muscle releases toxins leading to rhabdomyolysis and, potentially, acute kidney injury (AKI). The goal of this study...
Pathologic complete response (pCR) predicts the long-term outcome of neoadjuvantly treated (NAC) breast cancer (BC) but is reached in <10% of hormone-receptor-positive patients. Biomarkers enabling adjustment or interruption of an ineffective ther...
Tyrosine kinase substrate with four SH3 domains (Tks4) scaffold protein plays roles in cell migration and podosome formation and regulates systemic mechanisms such as adult bone homeostasis and adipogenesis. Mutations in the Tks4 gene (SH3PXD2b) caus...
Rolling element bearings are commonly used in rotating machines. Bearing fault detection and diagnosis play a critical role in machine operations to recognize bearing faults at their early stage and prevent machine performance degradation, improve op...
Breast cancer (BC) is the most frequent non-cutaneous malignancy in women. Histological grade, expression of estrogen and progesterone receptors (ER and PgR), overexpression/amplification of the human epidermal growth factor receptor 2 (HER2) oncogen...
Soil organic carbon (SOC), total nitrogen (TN), total phosphorus (TP), and total potassium (TK) are important indicators for evaluating soil fertility. Exploring the content and spatial distribution of these indicators is of great significance for op...
This article gives an in-depth analysis of the experimental data of the TK-1G sounding rocket installed with the satellite navigation system. It turns out that the data acquisition rate of the rocket sonde is high, making the collection of complete t...
A series of hybrid of triazoloquinoxaline-chalcone derivatives 7a–k were designed, synthesized, fully characterized, and evaluated for their cytotoxic activity against three target cell lines: human breast adenocarcinoma (MCF-7), human colon carcinom...
This study examined the relationship between spinal morphological changes and gait characteristics in patients with adolescent idiopathic scoliosis (AIS) using inertial measurement unit (IMU) analysis. Twenty-three female patients with AIS scheduled...
12 February 2023
The changes in lumbar lordosis angle (LL) and sacral slope angle (SS) related to upper limb elevation and thoracic kyphosis angle (TK) in baseball players with spondylolysis remain unclear. Herein, we investigated baseball players with spondylolysis...
1 November 2016
The purpose of this study was to evaluate the relationship between spine alignment and shoulder elevation in a kyphotic elderly population. Twenty-three consecutive female patients who underwent balloon kyphoplasty for spinal compression fractures wi...
26 January 2022
Web-based lifestyle interventions have attracted considerable research interest. Available evidence on such interventions suggests health-promoting effects, but further research is needed. Therefore, this study aims to investigate short-, medium-, an...
Background/Objective: Sinomenine hydrochloride (SH), a natural anti–rheumatic drug derived from the Chinese medicinal plant Sinomenium acutum, demonstrates disease–modifying properties but lacks comprehensive safety and toxicokinetic (TK)...
Two series of sugar esters with alkyl chain lengths varying from 5 to 12 carbon atoms, and with a head group consisting of glucose or galactose moieties, were synthesized. Equilibrium surface tension isotherms were measured, yielding critical micella...
Kernel transfer learning (KTL), as a kind of statistical transfer learning (STL), has provided significant solutions for cross-domain condition monitoring and fault diagnosis of bearings due to its ability to capture relationships and reduce the gap...
Brucellosis remains one of the most significant zoonotic diseases, posing a serious threat to both human health and livestock. This issue is particularly relevant for Kazakhstan, which is among the countries endemic for brucellosis with a high incide...
Background/Objectives: Chronic myeloid leukemia (CML) is primarily associated with the BCR:ABL1 fusion protein. Although tyrosine kinase inhibitors (TKIs) have markedly enhanced treatment outcomes, the development of agents with improved therapeutic...
Recently, with the development of embedded system hardware technology, there is a need to support various kinds of operating system (OS) operation in embedded systems. In mobile processors, ARM started to provide the virtualization extension support...
Molecular mechanisms involved in cardiac remodelling are not fully understood. To study the role of vascular endothelial growth factor receptor 1 (VEGFR-1) signaling in left ventricular hypertrophy (LVH) and heart failure, we used a mouse model lacki...
Combating acquired drug resistance of EGFR tyrosine kinase (TK) is a great challenge and an urgent necessity in the management of non-small cell lung cancers. The advanced EGFR (L858R/T790M/C797S) triple mutation has been recently reported, and there...
This study investigates the potential for recovering valuable minerals from feldspar tailings generated during industrial processing and commonly discarded as waste, causing both economic losses and environmental concerns. A hydrocyclone overflow sam...
Body posture develops during the growing period and can be documented using trunk photography. The study aims to evaluate the body posture in children aged 7–10 years undergoing a dedicated physical activities program versus regular school spor...
Soil nutrients play vital roles in vegetation growth and are a key indicator of land degradation. Accurate, rapid, and non-destructive measurement of the soil nutrient content is important for ecological conservation, degradation monitoring, and prec...
Background: It may be difficult to define what would constitute an abnormal spinal sagittal alignment. The same degree of malalignment may be found both in patients with pain and disability and in asymptomatic individuals. This study focuses on elder...
Gene mutations linked to diseases like cancer may be caused by exposure to environmental chemicals. The X-linked phosphatidylinositol glycan class A (PIG-A) gene, required for glycosylphosphatidylinositol (GPI) anchor biosynthesis, is a key target lo...
The apical hypokyphosis of scoliotic patients is thought to lead to decreased lung capacity and cause shortness of breath. Additionally, concave rod curve reduction is a problem in the correction of apical hypokyphosis in posterior spinal fusion surg...
The restoration of sagittal alignment is fundamental to the surgical correction of adolescent idiopathic scoliosis (AIS). Despite established techniques, some patients present with inadequate postoperative thoracic kyphosis (TK), which may increase t...
Understanding soil nutrients and stoichiometry across land-use types is essential for semiarid ecosystem management. We selected 130 sampling sites across four land-use types (dryland, paddy field, grassland, and forestland) in the Western Songnen Pl...
Surface activity and micelle formation of alkylguanidinium chlorides containing 10, 12, 14 and 16 carbon atoms in the hydrophobic tail were studied by combining conductivity and surface tension measurements with isothermal titration calorimetry. The...
Objectives: To examine the regulatory role of PCNA in MM, we have targeted PCNA with the experimental drug ATX-101 in three commercial cell lines (JJN3, RPMI 1660, AMO) and seven in-house patient-derived cell lines with a more primary cell-like pheno...
Crimean-Congo hemorrhagic fever virus (CCHFV) is the causative agent of a tick-borne infection with a significant mortality rate of up to 40% in endemic areas, with evidence of geographical expansion. Due to a lack of effective therapeutics and contr...
Background: This study aimed to compare the incidence and severity of cervical kyphosis before and after surgery between patients with adolescent idiopathic scoliosis (AIS) with major thoracolumbar/lumbar curves (Lenke type 5C group) and those with m...
University students face dietary transitions shaped by time constraints, campus food environments, and intensive exposure to food-related content on social media, yet the mechanisms linking digital exposure to observable food choices and overall diet...
Gold is transported in high-temperature chloride-bearing hydrothermal fluids in the form of AuCl2−. The stability of this complex has been extensively studied, but there is still considerable disagreement between available experimental data on...
The understanding of the pathogenic mechanisms and the clinicopathological forms caused by currently circulating African swine fever virus (ASFV) isolates is incomplete. So far, most of the studies have been focused on isolates classified within geno...
Heat stress poses a significant challenge to livestock farming, particularly affecting the health and productivity of high-yield dairy cows. This study develops a machine learning framework aimed at predicting the core body temperature (CBT) of dairy...
Soil microbial communities are important for nutrient cycling regulation in forest ecosystems. However, limited knowledge exists regarding the characteristics of these microbial communities in Masson pine (Pinus massoniana Lamb.) plantations of diffe...
Bovine respiratory disease (BRD) is a global prevalent multifactorial infection primarily caused by viral and bacterial coinfections. In China, Mycoplasma bovis (M. bovis) and bovine herpesvirus type 1 (BoHV-1) are the predominant pathogens associate...
Patients’ functional adaptation to pain can affect global sagittal alignment. This study evaluated the short-term spinal sagittal alignment change after transforaminal epidural steroid injection (TFESI) in lumbar spinal stenosis patients. Patie...
The evaluation of the fault diagnosis capability of a data center network (DCN) is important research in measuring network reliability. The g-extra diagnosability is defined under the condition that every component except the fault vertex set contain...
Concern over per- and polyfluoroalkyl substances (PFAS) has increased as more is learned about their environmental presence, persistence, and bioaccumulative potential. The limited monitoring, toxicokinetic (TK), and toxicologic data available are in...
This article is a response to the state of the art in monitoring the cooling capacity of quenching oils in industrial practice. Very often, a hardening shop requires a report with data on the cooling process for a particular quenching oil. However, t...
Here, we developed a novel oncolytic vaccinia virus (NOV) with the dual advantages of cancer selectivity and normal vessel reconstructive activity by replacing the viral thymidine kinase (vTk) and vaccinia growth factor (VGF) genes with genes encodin...
Phallus indusiatus is a prestigious macro-fungus with both nutritional and medicinal significance. However, its industrial development is limited by low yields and inconsistent quality, largely due to an incomplete understanding of the underlying soi...
We measured the ultrasonic properties and microstructure of two-phase binary mixtures of the ice–ammonia partial melt system, which was selected based on its importance for numerous planetary bodies. The equilibrium microstructure of ice–...
of 3