Special Issue "African Swine Fever Virus Infection"
Deadline for manuscript submissions: 31 July 2020.
Interests: Veterinary Medicine; Veterinary Pathology; Pathogenesis and Immunology of Infectious Diseases; African swine fever
Without any doubt, African swine fever (ASF) constitutes the biggest global problem the swine industry has ever faced. Since ASF appeared in Georgia in 2007 as a result of the transcontinental spread of genotype II ASFV isolates originally from Southeast Africa, the disease has spread like wild fire, first crossing Europe from East to West, and then jumping to Asia and reaching in 2018 the world’s largest pig producer, China. The disease has continued its unstoppable march, affecting several countries in Southeast Asia, until reaching in September 2019 the very doors of the Australian continent. This catastrophic scenario has forced to kill million pigs and has created a pessimistic outlook about the future of more than 500 million pigs, generating uncertainty that will last for years affecting international trade and markets.
The key role played by wild boar population in the spread and maintenance of ASF has opened a new scenario in which, along with the protection of domestic pigs, the control of the disease by vaccination in wild boar has been pointed as critical for the future outcome of the epidemic. So far, it has been assumed that ASFV infection in wild boar has a similar course as in domestic pigs. However, there are important gaps of knowledge regarding the pathogenesis and immunological mechanisms of ASF specifically in wild boar, so that not only biological differences with domestic pigs require to be identified, but also additional differences between experimental and natural ASFV infection in wild boar should be assessed.
Although over the last years some breakthroughs have been achieved, so far any attempt to develop a commercial vaccine against ASFV has failed due to the complexity of the causative agent, the Africa swine fever virus (ASFV). The precise nature of the protective responses has not been determined and protective antigens have not yet been identified. In addition, mechanisms by which the virus modulates the host response to infection are poorly understood.
In this issue, we would like to focus on all aspects of ASF that provide an update of our current knowledge of the disease and may contribute to vaccine development. Topics of interest include (but are not limited to) transmission pathways, host–virus interactions, mechanisms of infection and viral spread, cell-virus interactions, disease dynamics, clinical aspects, pathology and standardization of pathological evaluation protocols, disease pathogenesis, factors responsible for virus virulence, virus persistence, vaccines, immune responses correlated with protection and how these can be activated, development and improvement of diagnostic techniques, new ASFV isolates discovery, epidemiology and antiviral drugs.
Dr. Pedro J. Sánchez-Cordón
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- transmission pathways
- host–virus interactions
- mechanisms of infection and viral spread
- cell-virus interactions
- disease dynamics
- clinical courses
- disease pathogenesis
- virus virulence
- virus persistence
- immune response
- diagnostic techniques
- antiviral drugs
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.