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40 Results Found

  • Article
  • Open Access
1,594 Views
24 Pages

Refined Jianpi Huayu Jiedu Decoction Attenuates TAM-Induced Spasmolytic Polypeptide-Expressing Metaplasia (SPEM) by Modulating LCN2-Associated Mitochondrial Dysfunction

  • Chongkai Fang,
  • Sijia Zhang,
  • Peiyao He,
  • Yongheng Lai and ,
  • Rui Luo,
  • Yunshuo Zhang,
  • Sida Liu,
  • Zichun Xie,
  • Huafeng Pan and
  • Wei Liu
  • + 5 authors+ 0 author

24 April 2026

Background: Spasmolytic polypeptide-expressing metaplasia (SPEM) is an injury-induced gastric epithelial reprogramming state with limited therapeutic options. Although mitochondrial dysfunction has been implicated in epithelial stress responses, its...

(This article belongs to the Section Natural Products)
  • Article
  • Open Access
1 Citations
1,987 Views
16 Pages

HS-SPEM-GC-MS Analyses of Volatiles and Transcriptome Analysis of Camellia tetracocca in Response to Feeding by Empoasca onukii Matsuda

  • Ni Zhang,
  • Jinqiu Wang,
  • Tianyi Pu,
  • Zhibing Zhao and ,
  • Weiwen Tan,
  • Zhengwen Yu and
  • Yuehua Song
  • + 2 authors+ 0 author

15 October 2023

The tea leafhopper (Empoasca (Matsumurasca) onukii Matsuda, 1952) is the predominant pest infesting tea and causes significant losses in yield. Plants have evolved multiple defense responses to protect themselves from insect herbivores. Camellia tetr...

(This article belongs to the Special Issue Functional Genomics and Molecular Genetics Studies on Plant Regulation)
  • Article
  • Open Access
4 Citations
5,489 Views
18 Pages

Gastric Corpus Mucosal Hyperplasia and Neuroendocrine Cell Hyperplasia, but not Spasmolytic Polypeptide-Expressing Metaplasia, Is Prevented by a Gastrin Receptor Antagonist in H+/K+ATPase Beta Subunit Knockout Mice

  • Kristin Matre Aasarød,
  • Helge Lyder Waldum,
  • Astrid Kamilla Stunes,
  • Arne Kristian Sandvik and ,
  • Arnar Flatberg,
  • Patricia Mjønes,
  • Unni Syversen,
  • Ingunn Bakke and
  • Reidar Fossmark
  • + 4 authors+ 0 author

Proton pump inhibitor use is associated with an increased risk of gastric cancer, which may be mediated by hypergastrinemia. Spasmolytic polypeptide-expression metaplasia (SPEM) has been proposed as a precursor of gastric cancer. We have examined the...

(This article belongs to the Section Molecular Oncology)
  • Article
  • Open Access
330 Views
17 Pages

Berberine Prevents and Reverses Gastric Spasmolytic Polypeptide-Expressing Metaplasia by Modulating M2 Macrophage Polarization

  • Jia-Le Li,
  • Shi-Yi Ge,
  • Xing-Xing Zhou,
  • Rong Yan and ,
  • Ke-Xin Lin,
  • Si-Ran Wu,
  • Xiao-Dong Qu,
  • Na Wang,
  • Jian Wu and
  • Yong-Quan Shi
  • + 5 authors+ 0 author

24 September 2026

Spasmolytic polypeptide-expressing metaplasia (SPEM) is a critical gastric precancerous lesion with no approved pharmacological intervention. Berberine (BBR), a natural isoquinoline alkaloid, exhibits pleiotropic anti-inflammatory and antitumor activ...

(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
  • Article
  • Open Access
5 Citations
3,856 Views
16 Pages

Lead-Bismuth Eutectic: Atomic and Micro-Scale Melt Evolution

  • Roberto Montanari,
  • Alessandra Varone,
  • Luca Gregoratti,
  • Saulius Kaciulis and
  • Alessio Mezzi

27 September 2019

Element clustering and structural features of liquid lead-bismuth eutectic (LBE) alloy have been investigated up to 720 °C by means of high temperature X-ray diffraction (HT-XRD), X-ray Photoemission Spectroscopy (XPS) and Scanning Photoemission...

  • Article
  • Open Access
5 Citations
2,551 Views
16 Pages

The buffeting analysis of an uncertain long-span bridge deck was carried out in this paper. Due to the effect of strong spatial correlation of wind excitation, it should be assumed as partially coherent multiple excitations. The following includes a...

(This article belongs to the Special Issue Wind Nonlinear Analysis of Tall Buildings, High-Rise Structures, Flexible Bridges and Transmission Lines)
  • Article
  • Open Access
10 Citations
4,301 Views
9 Pages

Long-Term Effects of Low-Level Blast Exposure and High-Caliber Weapons Use in Military Special Operators

  • Melissa Hunfalvay,
  • Nicholas P. Murray,
  • William T. Creel and
  • Frederick R. Carrick

Chronic low-level blast exposure has been linked with neurological alterations and traumatic brain injury (TBI) biomarkers. Impaired smooth-pursuit eye movements (SPEM) are often associated with TBI. The purpose of this study was to determine whether...

(This article belongs to the Section Environmental Neuroscience)
  • Article
  • Open Access
26 Citations
3,667 Views
22 Pages

SpemNet: A Cotton Disease and Pest Identification Method Based on Efficient Multi-Scale Attention and Stacking Patch Embedding

  • Keyuan Qiu,
  • Yingjie Zhang,
  • Zekai Ren,
  • Meng Li and ,
  • Qian Wang,
  • Yiqiang Feng and
  • Feng Chen
  • + 2 authors+ 0 author

2 September 2024

We propose a cotton pest and disease recognition method, SpemNet, based on efficient multi-scale attention and stacking patch embedding. By introducing the SPE module and the EMA module, we successfully solve the problems of local feature learning di...

(This article belongs to the Special Issue Artificial Intelligence (AI) and Insect Pests Management: Securing Food Security, Human Health, and Natural Resources)
  • Article
  • Open Access
4 Citations
3,916 Views
13 Pages

Synchrotron-Based X-ray Photoelectron Microscopy of LMO/LAGP/Cu Thin-Film Solid-State Lithium Metal Batteries

  • Majid Kazemian,
  • Matteo Amati,
  • Luca Gregoratti,
  • Maya Kiskinova and
  • Benedetto Bozzini

9 October 2023

Solid-state batteries (SSB), characterized by solid-state electrolytes—in particular inorganic ones (ISSE)—are an ideal option for the safe implementation of metallic Li anodes. Even though SSBs with ISSEs have been extensively investigat...

(This article belongs to the Section Battery Materials and Interfaces: Anode, Cathode, Separators and Electrolytes or Others)
  • Article
  • Open Access
2 Citations
946 Views
15 Pages

Comparison of the Precision of Smooth Pursuit in Humans and Head Unrestrained Monkeys

  • Jan Churan,
  • Doris I. Braun,
  • Karl R. Gegenfurtner and
  • Frank Bremmer

9 November 2018

Direct comparison of results of humans and monkeys is often complicated by differences in experimental conditions. We replicated in head unrestrained macaques experiments of a recent study comparing human directional precision during smooth pursuit e...

  • Article
  • Open Access
30 Citations
5,054 Views
17 Pages

Sericin/Human Placenta-Derived Extracellular Matrix Scaffolds for Cutaneous Wound Treatment—Preparation, Characterization, In Vitro and In Vivo Analyses

  • Jayavardhini Bhoopathy,
  • Sankari Dharmalingam,
  • Weslen Vedakumari Sathyaraj,
  • Selvarajan Rajendran and ,
  • Shibormi Rymbai,
  • Rethinam Senthil and
  • Raji Atchudan
  • + 2 authors+ 0 author

Human placenta is loaded with an enormous amount of endogenous growth factors, thereby making it a superior biomaterial for tissue regeneration. Sericin is a naturally occurring silk protein that is extensively used for biomedical applications. In th...

(This article belongs to the Special Issue Functional Polymeric Materials for Drug Delivery and Sustained Drug Release)
  • Review
  • Open Access
1 Citations
2,690 Views
18 Pages

Catalytically Active Materials Visualized by Scanning Photoelectron Spectro-Microscopy

  • Matteo Amati,
  • Lada V. Yashina,
  • Philipp Winkler,
  • Kevin Sparwasser and ,
  • Zygmunt Milosz,
  • Günther Rupprechter and
  • Luca Gregoratti
  • + 2 authors+ 0 author

26 June 2024

Modern catalysts are complex systems whose performance depends both on space and time domains and, most importantly, on the operational environment. As a direct consequence, understanding their functionalities requires sophisticated techniques and to...

(This article belongs to the Special Issue In Situ and Operando Catalyst Characterization)
  • Article
  • Open Access
5 Citations
1 Views
2 Pages

Leptotrichia species (LS) is an anaerobic Gram negative bacillus in the Bacteroidaceae family and part of the normal human oral flora. It is rarely pathogenic, but occasionally causes diseases in immunocompromised hosts. I am reporting a case of cavi...

  • Review
  • Open Access
16 Citations
5,141 Views
27 Pages

ESCA as a Tool for Exploration of Metals’ Surface

  • Eleonora Bolli,
  • Saulius Kaciulis and
  • Alessio Mezzi

3 December 2020

The main principles and development of electron spectroscopy for chemical analysis (ESCA) are briefly reviewed. The role of ESCA techniques (X-ray photoelectron spectroscopy and Auger electron spectroscopy) in the investigation of metallic surfaces i...

(This article belongs to the Special Issue Metal Surfaces)
  • Article
  • Open Access
6 Citations
1 Views
2 Pages

Lasiodiplodia theobromae Keratitis: A Rare Fungi from Eastern India

  • Suman Saha,
  • Jayangshu Sengupta,
  • Debdulal Banerjee and
  • Archana Khetan

30 January 2013

We report here a case of a 32-year old female with a history of minor trauma presented with total corneal ulcer and hypopyon in the left eye. Microbiological examination of corneal scraping showed refractile hyphae with asepted branching filaments an...

  • Review
  • Open Access
37 Citations
13,842 Views
17 Pages

14 August 2015

Gastric cancer is still a leading cause of cancer-related mortality worldwide in spite of declining incidence. Gastric cancers are, essentially, adenocarcinomas and one of the strongest risk factors is still infection with Helicobacter pylori. Within...

(This article belongs to the Special Issue Molecular and Cellular Basis of Regeneration and Tissue Repair)
  • Review
  • Open Access
83 Citations
15,543 Views
16 Pages

Metaplasia in the Stomach—Precursor of Gastric Cancer?

  • Hiroto Kinoshita,
  • Yoku Hayakawa and
  • Kazuhiko Koike

27 September 2017

Despite a significant decrease in the incidence of gastric cancer in Western countries over the past century, gastric cancer is still one of the leading causes of cancer-related deaths worldwide. Most human gastric cancers develop after long-term Hel...

(This article belongs to the Special Issue Cancer Stem Cells)
  • Review
  • Open Access
20 Citations
7,345 Views
17 Pages

25 January 2024

Gastric cancer is one of the leading causes of cancer deaths worldwide, with chronic gastritis representing the main predisposing factor initiating the cascade of events leading to metaplasia and eventually progressing to cancer. A widely accepted cl...

(This article belongs to the Special Issue Crosstalk between Inflammation and Carcinogenesis)
  • Article
  • Open Access
2 Citations
1,332 Views
30 Pages

This paper proposes a two-dimensional (2D) generalized equivalent magnetic network (GEMN) model suitable for surface-mounted permanent magnet electric machines (SPEMs). The model divides the SPEM into eight types of regions: stator yoke, stator tooth...

  • Article
  • Open Access
34 Citations
7,279 Views
23 Pages

16 September 2020

The study proposes Secondary Precipitation Estimate Merging using Machine Learning (SPEM2L) algorithms for merging multiple global precipitation datasets to improve the spatiotemporal rainfall characterization. SPEM2L is applied over the Krishna Rive...

(This article belongs to the Special Issue Artificial Intelligence and Earth Observation in Support of the UN Sustainable Development Goals)
  • Article
  • Open Access
10 Citations
3,748 Views
21 Pages

19 March 2021

Carbonation of cementitious binders implies gradual capture of CO2 and significant compensation for the abundant cement-related CO2 emissions. Therefore, one should always look at the CO2-sequestration-to-emission ratio (CO2SP/EM). Here, this was don...

(This article belongs to the Special Issue Concrete and Mortar with Non-conventional Materials)
  • Article
  • Open Access
1 Citations
2,026 Views
12 Pages

19 August 2024

The purpose of this probabilistic assessment was to estimate the risk of sulfur-induced polioencephalomalacia (S-PEM) for beef raised across Texas, from a dietary perspective. Ruminant nutritionists in Amarillo, TX, formulated two typical nutritional...

(This article belongs to the Topic Health Risk Assessment of the Trace and Macro Elements)
  • Article
  • Open Access
2 Citations
2,598 Views
14 Pages

Machine Learning-Based Detection of Cognitive Impairment from Eye-Tracking in Smooth Pursuit Tasks

  • Vida Groznik,
  • Andrea De Gobbis,
  • Dejan Georgiev,
  • Aleš Semeja and
  • Aleksander Sadikov

11 July 2025

Mild cognitive impairment represents a transitional phase between healthy ageing and dementia, including Alzheimer’s disease. Early detection is essential for timely clinical intervention. This study explores the viability of smooth pursuit eye...

(This article belongs to the Special Issue Artificial Intelligence Applications in Healthcare and Precision Medicine, 2nd Edition)
  • Review
  • Open Access
536 Views
35 Pages

Eye-Tracking in Bipolar Disorder: A Methodology-Focused Narrative Review

  • Evrim Bayrak Oruc,
  • Buket Koparal,
  • Jonathan Jacobs,
  • Aasef G. Shaikh and
  • Keming Gao

24 August 2026

Background and Objectives: This methodology-focused narrative review synthesizes the eye-tracking literature in bipolar disorder (BD) to evaluate the utility of such technology in identifying potential state or trait biomarkers for BD. Methods: A Pub...

(This article belongs to the Section Psychiatry)
  • Article
  • Open Access
6 Citations
5,414 Views
20 Pages

Spatially Resolved XPS Characterization of Electrochemical Surfaces

  • Benedetto Bozzini,
  • Danjela Kuscer,
  • Matteo Amati,
  • Luca Gregoratti and ,
  • Patrick Zeller,
  • Tsvetina Dobrovolska and
  • Ivan Krastev
  • + 2 authors+ 0 author

15 April 2019

Synchrotron-based scanning photoelectron microscopy (SPEM) has opened unique opportunities for exploiting processes occurring at surfaces and interfaces, which control the properties of materials for electrochemical devices, where issues of chemical...

(This article belongs to the Special Issue Electrochemical Surface Science: Basics and Applications)
  • Article
  • Open Access
20 Citations
4,755 Views
14 Pages

Combining Computed Tomography and Histology Leads to an Evolutionary Concept of Hepatic Alveolar Echinococcosis

  • Johannes Grimm,
  • Annika Beck,
  • Juliane Nell,
  • Julian Schmidberger and ,
  • Andreas Hillenbrand,
  • Ambros J. Beer,
  • Balázs Dezsényi,
  • Rong Shi,
  • Meinrad Beer and
  • Tilmann Graeter
  • + 11 authors+ 6 authors

Alveolar echinococcosis (AE) is caused by the intermediate stage of Echinococcus multilocularis. We aimed to correlate computed tomography (CT) data with histology to identify distinct characteristics for different lesion types. We classified 45 samp...

  • Article
  • Open Access
2 Citations
2,775 Views
14 Pages

The Impact of Carbon on Electronic Structure of N-Doped ZnO Films: Scanning Photoelectron Microscopy Study and DFT Calculations

  • Elzbieta Guziewicz,
  • Sushma Mishra,
  • Matteo Amati,
  • Luca Gregoratti and
  • Oksana Volnianska

27 December 2024

A Scanning Photoelectron Microscopy (SPEM) experiment has been applied to ZnO:N films deposited by Atomic Layer Deposition (ALD) under O-rich conditions and post-growth annealed in oxygen at 800 °C. State-of-the-Art spatial resolution (130 nm) al...

(This article belongs to the Section Theory and Simulation of Nanostructures)
  • Article
  • Open Access
1 Citations
4,958 Views
16 Pages

Assessing Smooth Pursuit Eye Movements Using Eye-Tracking Technology in Patients with Schizophrenia Under Treatment: A Pilot Study

  • Luis Benigno Contreras-Chávez,
  • Valdemar Emigdio Arce-Guevara,
  • Luis Fernando Guerrero,
  • Alfonso Alba and ,
  • Miguel G. Ramírez-Elías,
  • Edgar Roman Arce-Santana,
  • Victor Hugo Mendez-Garcia,
  • Jorge Jimenez-Cruz,
  • Anna Maria Maddalena Bianchi and
  • Martin O. Mendez
  • + 5 authors+ 0 author

21 August 2025

Schizophrenia is a complex disorder that affects mental organization and cognitive functions, including concentration and memory. One notable manifestation of cognitive changes in schizophrenia is a diminished ability to scan and perform tasks relate...

(This article belongs to the Special Issue Biomedical Imaging, Sensing and Signal Processing)
  • Article
  • Open Access
9 Citations
3,136 Views
19 Pages

FEM Simulation of AlSi10Mg Artifact for Additive Manufacturing Process Calibration with Industrial-Computed Tomography Validation

  • Cesare Patuelli,
  • Enrico Cestino,
  • Giacomo Frulla,
  • Federico Valente and ,
  • Guido Servetti,
  • Fabio Esposito and
  • Luca Barbero
  • + 2 authors+ 0 author

30 June 2023

Dimensional accuracy of selective laser melting (SLM) parts is one of manufacturers’ major concerns. The additive manufacturing (AM) process is characterized by high-temperature gradients, consolidation, and thermal expansion, which induce resi...

(This article belongs to the Section Advanced Materials Characterization)
  • Communication
  • Open Access
11 Citations
6,255 Views
8 Pages

Strain Induced Phase Transition of WS2 by Local Dewetting of Au/Mica Film upon Annealing

  • Tomasz Kosmala,
  • Pawel Palczynski,
  • Matteo Amati,
  • Luca Gregoratti and ,
  • Hikmet Sezen,
  • Cecilia Mattevi,
  • Stefano Agnoli and
  • Gaetano Granozzi
  • + 3 authors+ 0 author

22 December 2020

Here, we present a proof-of-concept experiment where phase engineering at the nanoscale of 2D transition metal dichalcogenides (TMDC) flakes (from semiconducting 2H phase to metallic 1T phase) can be achieved by thermal annealing of a TMDC/Au/mica sy...

  • Tutorial
  • Open Access
37 Citations
11,417 Views
8 Pages

14 October 2021

Among echinococcoses diseases of human interest, two have a global public health impact: cystic and alveolar echinococcosis caused by Echinococcus granulosus sensu lato and Echinococcus multilocularis, respectively. Cystic and alveolar echinococcosis...

(This article belongs to the Special Issue Alveolar Echinococcosis: Joining Hands to Tackle a Lethal Parasitosis)
  • Article
  • Open Access
9 Citations
3,761 Views
22 Pages

Graphene Coating Obtained in a Cold-Wall CVD Process on the Co-Cr Alloy (L-605) for Medical Applications

  • Łukasz Wasyluk,
  • Vitalii Boiko,
  • Marta Markowska,
  • Mariusz Hasiak and ,
  • Maria Luisa Saladino,
  • Dariusz Hreniak,
  • Matteo Amati,
  • Luca Gregoratti,
  • Patrick Zeller and
  • Magdalena Wawrzyńska
  • + 7 authors+ 2 authors

Graphene coating on the cobalt-chromium alloy was optimized and successfully carried out by a cold-wall chemical vapor deposition (CW-CVD) method. A uniform layer of graphene for a large area of the Co-Cr alloy (discs of 10 mm diameter) was confirmed...

(This article belongs to the Special Issue Carbon-Based Nanomaterials 2.0)
  • Article
  • Open Access
7 Citations
5,376 Views
19 Pages

12 January 2021

The planning of system development efforts is crucial to the successful realization of projects. However, development planning typically lacks systematic, engineering discipline, and consequently risks project and business success. Model-based proces...

(This article belongs to the Section Artificial Intelligence and Digital Systems Engineering)
  • Review
  • Open Access
16 Citations
8,975 Views
13 Pages

18 January 2016

Electrochemical Promotion of Catalysis (EPOC) with alkali ionic conductors has been widely studied in literature due to its operational advantages vs. alkali classical promotion. This phenomenon allows to electrochemically control the alkali promoter...

(This article belongs to the Special Issue Surface Chemistry and Catalysis)
  • Article
  • Open Access
6 Citations
2,251 Views
17 Pages

Effects of Inoculation with Koji and Strain Exiguobacterium profundum FELA1 on the Taste, Flavor, and Bacterial Community of Rapidly Fermented Shrimp Paste

  • Huanming Liu,
  • Ailian Huang,
  • Jiawen Yi,
  • Meiyan Luo and ,
  • Guili Jiang,
  • Jingjing Guan,
  • Shucheng Liu,
  • Chujin Deng and
  • Donghui Luo
  • + 4 authors+ 0 author

13 August 2024

This study was conducted to investigate the effect of inoculation with Exiguobacterium profundum FELA1 isolated from traditional shrimp paste and koji on the taste, flavor characteristics, and bacterial community of rapidly fermented shrimp paste. E-...

(This article belongs to the Section Food Microbiology)
  • Article
  • Open Access
30 Citations
5,913 Views
15 Pages

Hybrid Ensemble Deep Learning Model for Advancing Ischemic Brain Stroke Detection and Classification in Clinical Application

  • Radwan Qasrawi,
  • Ibrahem Qdaih,
  • Omar Daraghmeh,
  • Suliman Thwib and ,
  • Stephanny Vicuna Polo,
  • Siham Atari and
  • Diala Abu Al-Halawa
  • + 2 authors+ 0 author

Ischemic brain strokes are severe medical conditions that occur due to blockages in the brain’s blood flow, often caused by blood clots or artery blockages. Early detection is crucial for effective treatment. This study aims to improve the dete...

(This article belongs to the Section AI in Imaging)
  • Article
  • Open Access
6 Citations
2,761 Views
22 Pages

In this paper, a robust composite dynamic event-triggered formation control scheme is proposed for multiple underactuated surface vehicles (USVs) from two aspects, i.e., guidance and control. In the guidance module, a novel dual-layer line-of-sight (...

(This article belongs to the Special Issue Control Theory and Applications in Marine Autonomous Vehicles)
  • Article
  • Open Access
56 Citations
6,001 Views
19 Pages

Synthesis and Characterization of MWCNT-COOH/Fe3O4 and CNT-COOH/Fe3O4/NiO Nanocomposites: Assessment of Adsorption and Photocatalytic Performance

  • Adina Stegarescu,
  • Humberto Cabrera,
  • Hanna Budasheva,
  • Maria-Loredana Soran and ,
  • Ildiko Lung,
  • Francesca Limosani,
  • Dorota Korte,
  • Matteo Amati,
  • Gheorghe Borodi and
  • Stefano Bellucci
  • + 8 authors+ 3 authors

30 August 2022

In this study the adsorption and photodegradation capabilities of modified multi-walled carbon nanotubes (MWCNTs), using tartrazine as a model pollutant, is demonstrated. MWCNT-COOH/Fe3O4 and MWCNT-COOH/Fe3O4/NiO nanocomposites were prepared by preci...

(This article belongs to the Special Issue Functionalized Magnetite Nanomaterials — Synthesis, Properties, and Applications)
  • Article
  • Open Access
8 Citations
2,843 Views
23 Pages

Identification and Functional Prediction of CircRNAs in Leaves of F1 Hybrid Poplars with Different Growth Potential and Their Parents

  • Weixi Zhang,
  • Zhengsai Yuan,
  • Jing Zhang,
  • Xiaohua Su and ,
  • Qinjun Huang,
  • Qi Liu and
  • Changjun Ding
  • + 2 authors+ 0 author

23 January 2023

Circular RNAs (CircRNAs) regulate plant growth and development; however, their role in poplar heterosis is unclear. We identified 3722 circRNAs in poplar leaves, most of which were intergenic (57.2%) and exonic (40.2%). The expression of circRNAs in...

(This article belongs to the Special Issue The World of Plant Non-coding RNAs)
  • Article
  • Open Access

Although a wide range of diagnostic tools have been used to assess CNS involvement in autoimmune disease, no single technique has proven to be reliable. Patients with these diseases often underwent detailed neurocognitive test batteries which are ext...