Cancer Stem Cells
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (30 June 2017) | Viewed by 98268
Special Issue Editors
Interests: pathology; tumor microenvironment; carcinogenesis; stem cell; mouse models
Special Issues, Collections and Topics in MDPI journals
Interests: liver carcinogenesis; cancer chemoprevention; chronic hepatitis; metabolic syndrome; retinoid; phytochemicals; clinical trial
Special Issues, Collections and Topics in MDPI journals
Interests: colorectal carcinogenesis; cancer chemiprevention; inflammatory bowel disease; ulcerative colitis; Crohn’s disease; animal model
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The cancer stem cell (CSC) theory assumes that a small population of cells with stem cell like features is causative of tumor growth, resistance, and recurrence in many human malignancies. This theory could be a beneficial paradigm for producing innovative and targeted drug therapies.
Currently, controversial issues have arisen regarding the CSCs. First, it is unclear whether CSCs can give rise to multiple differentiated cell types. Second, it is unclear whether normal cellular precursors of CSCs are true normal tissue SCs; for example, the CSC model usually stands on the basis of experimental characterizations of cancer cell populations. In normal tissue SCs, the surrounding microenvironment is considered to be normal, however, CSCs usually have aberrant microenvironments, such as severe inflammation, hypoxia, and/or low nutrient conditions.
We expect that this Special Issue will provide hot information on the above-mentioned topics, and will be of interest to scientists and clinicians working in the area of cancer research.
Dr. Hiroyuki Tomita
Prof. Dr. Takuji Tanaka
Prof. Dr. Masahito Shimizu
Guest Editors
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Keywords
- Cancer stem cell
- Stem cell marker
- Tissue stem cell
- Carcinogenesis
- Chemoprevention
- Animal model
- Inflammation
- Tumor microenvironment
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