A road profile can be a good reference feature for vehicle localization when a Global Positioning System signal is unavailable. However, cost effective and compact devices measuring road profiles are not available for production vehicles. This paper...
The goal of the study is to reveal the reasons (strategies) behind the use of “virtual masks” (fake profiles and altered identities) by real (human) users of social media networks (SMNs) within a cultural context, specifically in Armenia....
In the semiconductor etch process, as the critical dimension (CD) decreases and the difficulty of the process control increases, in-situ and real-time etch profile monitoring becomes important. It leads to the development of virtual metrology (VM) te...
This study aimed to characterize students from the Instituto Tecnológico del Valle de Etla (ITVE), located in Oaxaca, Mexico, within the virtual learning environment (VLE) and to identify the main technological challenges affecting their learn...
In the last years, several attempts to combine the Internet of Things (IoT) and social networking have been made. In the meantime, things involved in IoT are becoming increasingly sophisticated and intelligent, showing a behavior that tends to look l...
In this study, we describe the input data and processing steps to find antiviral lead compounds by a virtual screen. Two-dimensional and three-dimensional filters were designed based on the X-ray crystallographic structures of viral neuraminidase co-...
The creation and usage of serious games on virtual reality (VR) and/or interactive platforms for the teaching of architecture, construction, urban planning, and other derived areas, such as security and risk prevention, require design processes, stud...
The world is undergoing rapid changes in its climate, environment, and ecosystems due to increasing population growth, urbanization, and industrialization. Numerical simulation is becoming an important vehicle to enhance the understanding of these ch...
Natural products have been the main source of bioactive molecules for centuries. We tested the biological profile of two metabolites extracted from Gentiana lutea L. by means of computational techniques and in vitro assays. The two molecules (loganic...
LC-MS-assisted metabolomic profiling of the Red Sea-derived brown algae Sargassum cinereum “Sargassaceae” dereplicated eleven compounds 1–11. Further phytochemical investigation afforded two new aryl cresol 12–13, along with eight known compounds 14–...
Background/Objectives: Glucagon-like peptide-1 (GLP-1) receptor is currently one of the most explored targets exploited for the management of diabetes and obesity, with many aspects of its mechanisms behind cardiovascular protection yet to be fully e...
Scientific applications often require substantial amount of computing resources for running challenging jobs potentially consisting of many tasks from hundreds of thousands to even millions. As a result, many institutions collaborate to solve large-s...
Background/Objectives: Early childhood caries (ECC) remains a major public health concern, with Streptococcus mutans as a primary etiological agent. Current treatments rely on broad-spectrum antimicrobials, which can disrupt the oral microbiome and p...
Piezoelectric micromachined ultrasound transducers (PMUT) incorporating lead zirconate titanate PbZr0.52Ti0.48O3 (PZT) thin films were investigated for miniaturized high-frequency ultrasound systems. A recently developed process to remove a PMUT from...
As the internet and complex network infrastructures continue to expand, so does the threat of sophisticated cyberattacks, compelling organizations to adopt advanced proactive defenses. A cornerstone of these defensive strategies is the honeypot. Howe...
The PI3K plays a crucial role in cancer progression, and the development of PI3K inhibitors has always been a hot research direction in oncology. Through virtual screening and docking, potential lead compounds were identified. ADMET prediction reveal...
Background: Eukaryotic elongation factor 2 kinase (eEF2K) regulates the elongation stage of protein synthesis by phosphorylating eEF2, a process related to various diseases including cancer and cardiovascular and neurodegenerative diseases. In this s...
The “Long-COVID syndrome” has posed significant challenges due to a lack of validated therapeutic options. We developed a novel multi-step virtual screening strategy to reliably identify inhibitors against 3-chymotrypsin-like protease of...
Background: Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by impaired differentiation, apoptosis resistance, and metabolic reprogramming, which collectively contribute to therapeutic resistance and poor clinical...
Deep learning is a machine learning technique to model high-level abstractions in data by utilizing a graph composed of multiple processing layers that experience various linear and non-linear transformations. This technique has been shown to perform...
A virtual machine with a conventional offloading scheme transmits and receives all context information to maintain program consistency during communication between local environments and the cloud server environment. Most overhead costs incurred duri...
This paper presents a Thermal Deformation defect prediction method for layered printing using Convolutional Generative Adversarial Network (CGAN). Firstly, the original manifold mesh is converted into layered image in Printing Coordinate System (PCS)...
Virtual reality (VR) has become increasingly popular and has started entering homes, schools, and clinics, yet evidence on how children interact during free-form, unguided play remains limited. Understanding how interaction dynamics relate to player...
EphB3 is a major key player in a variety of cellular activities, including cell migration, proliferation, and apoptosis. However, the exact role of EphB3 in cancer remains ambiguous. Accordingly, new EphB3 inhibitors can increase the understanding of...
The crystallized ligands in the Protein Data Bank (PDB) can be treated as the inverse shapes of the active sites of corresponding proteins. Therefore, the shape similarity between a molecule and PDB ligands indicated the possibility of the molecule t...
This study aims to design improved inhibitors targeting the thymidylate kinase (TMK) of Mycobacterium tuberculosis (Mtb), the causative agent of infectious disease tuberculosis that is associated with high morbidity and mortality in developing countr...
University dormitories, as crucial living spaces for students, significantly influence their physical and mental health based on the quality of spatial design. However, whether the use of an upper bunk (UB) or lower bunk (LB) induces differential phy...
Conical screw compressors are equipment used to compress air or other gases, using a mechanism consisting of two conically shaped rotors (screws), which rotate one inside the other. This specific design offers advantages in terms of its efficiency, d...
The advantages of increased penetration of distributed generation are also accompanied by several challenges, low inertia being one of them, which threatens the grid stability. An emerging approach to confront this problem is the introduction of so-c...
Underutilized biowaste materials are investigated for their potential as sustainable textile colorants through an approach based on mass spectrometry, bioinformatics, and chemometrics. In this study, colorful decoctions were prepared from the outer b...
With the widespread use of substations around the world, oil jet fire accidents from transformer oil-filled equipment in substations caused by faults have occurred from time to time. In this paper, a series of transformer oil jet fire experiments are...
Dental caries, a global oral health concern, is a biofilm-mediated disease. Streptococcus mutans, the most prevalent oral microbiota, produces extracellular enzymes, including glycosyltransferases responsible for sucrose polymerization. In bacterial...
Cannabis sativa L. is a plant belonging to the Cannabaceae family, cultivated for its psychoactive cannabinoid (Δ9-THC) concentration or for its fiber and nutrient content in industrial use. Industrial hemp shows a low Δ9-THC level and is...
Computer-aided drug design (CADD) techniques allow the identification of compounds capable of modulating protein functions in pathogenesis-related pathways, which is a promising line on drug discovery. Marine natural products (MNPs) are considered a...
15 July 2020
A common problem among students is the problem of delaying important work activities, which is conceptualized as procrastination. Since procrastination can cause considerable costs for society, we would like to find a method to effectively alleviate...
26 August 2019
Accumulated evidence claims that urban green spaces (UGS) have a positive impact on the physical and mental health of humans. However, little information is available to clearly reveal what the most important driving factors are for human psychophysi...
Form grinding is a precision machining method for the modified ZI worms, and the grinding accuracy mainly depends on the dressing accuracy of the grinding wheel’s profile. A mathematical model of the modified involute helicoid of ZI worms is es...
Pet health insurance can reduce the financial burden of veterinary care and ensure adequate treatment for companion animals. In France, where 67% of households own at least one pet and 68% of owners consider them family members, awareness of pet insu...
Hybrid renewable energy systems (HRESs), mixing conventional and renewable power sources and occasionally storage units, have become the norm regarding electricity generation. Robust long-term planning of such systems requires stakeholders to test di...
The use of computational methodologies for chemical database mining and molecular similarity searching or structure-activity relationship analysis has become an integral part of modern chemical and pharmaceutical research. These types of computationa...
In most situations, for the proper design of a gerotor pump, numerous parameters must be taken into account: the pump geometry, the properties of the materials from which the pumps are made (Young’s modulus, Poisson’s coefficient, frictio...
Background: During the previous decade a new class of benzamide-based inhibitors of 2-trans enoyl-acyl carrier protein reductase (InhA) of Mycobacterium tuberculosis (Mt) with unusual binding mode have emerged. Here we report in silico design and eva...
Cost-effective therapy of neglected and tropical diseases such as malaria requires everlasting drug discovery efforts due to the rapidly emerging drug resistance of the plasmodium parasite. We have carried out computational design of new inhibitors o...
The virtuality of organizational teams have gained interest and popularity in recent years, and have become more prevalent amidst the COVID-19 pandemic. Organizational productivity and team relationship-building may suffer certain pitfalls in virtual...
8 February 2020
Sexting consists of sending, receiving, and distributing images of sexually suggestive content through electronic devices. This practice is one of the new ways of linking sex affectively through virtual environments, especially in adolescence. Howeve...
Virtualization technologies are characterizing major advancements in the Internet of Things (IoT) arena, as they allow for achieving a cyber-physical world where everything can be found, activated, probed, interconnected, and updated at both the virt...
Timber construction is a contemporary solution where sales are performed through in-store trade. Timber house e-commerce may stimulate global markets, and in times of intense remote routines, it is useful to improve the performance of the wood and co...
N-(2-hydroxyphenyl)-1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol -1-yl)propyl]piperidine-4-carboxamide (D2AAK4) is a multitarget ligand of aminergic G protein-coupled receptors (GPCRs) identified in structure-based virtual screening. Here we present detai...
High-frequency skywave propagation can be heavily impacted by D- and E-region dynamics requiring accurate global measurements to optimize performance. A standard measurement technique is to use ionosondes, but they are unable to measure below 1 MHz a...
UAV-enabled Integrated Sensing and Communication (ISAC) systems simultaneously support target sensing and communication and, combined with their abilities in autonomy and control situations, they have the potential to be deployed for search and rescu...
of 19