Heterocyclic Compounds and Their Application in Therapy
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (15 April 2023) | Viewed by 107388
Special Issue Editors
Interests: chemistry of heterocyclic compounds; microwave-assisted chemistry; sustainable methodologies; green chemistry applied to bioactive compounds: kinase inhibitors; Alzheimer's disease; down syndrome; cancer
Special Issues, Collections and Topics in MDPI journals
Interests: design, synthesis and biological evaluation of heterocyclic compounds for therapeutic purposes (mycology, parasitology, bacteriology and cancer); inhibitors of kinase signaling pathways; ADMET properties of molecules of biological interest
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Heterocycles are present in numerous organic compounds of interest in biology, pharmacology, and medicine. Aromatic and non-aromatic molecules are still one of the largest areas of research in organic and medicinal chemistry. Exploring novel techniques or methods for synthesizing and functionalizing these compounds has been boosted, until becoming one of the major axes of sustainable chemistry. Heterocycles exhibit unique structures leading to several applications in the design of drugs. Presence of heteroatoms (e.g., N, S, and O) in the cyclic molecular structures results in significant physicochemical properties. Hydrogen-bond donors and acceptors in these rigid frameworks allow hydrogen-bond interactions with receptors and/or target enzymes, enhancing binding affinity and improving therapeutic potency. Heterocycles can also be involved in the design of prodrugs and can modulate the lipophilicity of bioactive molecules, thus varying their pharmacokinetic and pharmaceutical properties. This Special Issue aims to review recent developments in the design, synthesis, and pharmaceutical properties of natural products and synthetic compounds containing aromatic heterocyclic systems.
Prof. Dr. Thierry Besson
Prof. Dr. Pascal Marchand
Guest Editors
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Keywords
- medicinal chemistry
- bioactive heterocyclic compounds
- chemical space
- chemical tools
- innovative and sustainable synthetic routes
- molecular modelling studies
- pharmacological properties
- prodrugs: design and development
- in vitro and in vivo studies
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